47 completed. 47 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 47 | Completed 47 |
| Phase 2 | 3 | Completed 3 |
Follow Dextromethorphan: new trials by email Literature Review of Dextromethorphan trials Research Report on Dextromethorphan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Effect of Capivasertib on the Pharmacokinetics of Oral Dextromethorphan (CYP2D6 Substrate) in Healthy Participants Dextromethorphan, Capivasertib - Healthy Participants | Phase 1 | Completed | AstraZeneca | 42 | 2026-03-19 | 2026-07-27 |
| A Study of IBI351 in Healthy Subjects Itraconazole, IBI351, Dextromethorphan - Healthy Subjects | Phase 1 | Completed | Innovent Biologics (Suzhou) Co. Ltd. | 24 | 2023-03-10 | 2023-10-24 |
| DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan Acoziborole, Midazolam, Dextromethorphan - Trypanosomiasis, African | Phase 1 | Completed | Drugs for Neglected Diseases | 20 | 2023-02-09 | 2023-07-17 |
| A Drug Interaction Study of LY3871801 in Healthy Participants LY3871801, Methotrexate, Warfarin - Healthy | Phase 1 | Completed | Eli Lilly and Company | 39 | 2022-11-02 | 2023-04-18 |
| A Study of Imlunestrant (LY3484356) in Female Healthy Participants Imlunestrant, Repaglinide, Omeprazole - Healthy | Phase 1 | Completed | Eli Lilly and Company | 113 | 2022-07-07 | 2025-12-12 |
| Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir Midazolam, Repaglinide, Dextromethorphan - Malaria | Phase 1 | Completed | Novartis Pharmaceuticals | 48 | 2022-03-09 | 2022-11-04 |
| PK Study to Assess Drug-drug Interaction and QTc Between Sitravatinib and a Cocktail of Substrates Sitravatinib, Warfarin, Dextromethorphan - Advanced Solid Tumor | Phase 1 | Completed | Mirati Therapeutics Inc. | 40 | 2021-04-08 | 2024-05-08 |
| Phenotyping of High Dose Rifampicin phenotyping cocktail, rifampicin - Tuberculosis | Phase 1 | Completed | Radboud University Medical Center | 25 | 2021-01-07 | 2021-08-17 |
| Drug-drug Interaction Study of KL1333 in Healthy Subjects KL1333, Flurbiprofen, Dextromethorphan - Mitochondrial Disease | Phase 1 | Completed | Abliva AB | 14 | 2020-11-10 | 2021-10-20 |
| Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive Disorder Dextromethorphan - MDD, Treatment Resistant Depression | Phase 1 | Completed | Johns Hopkins University | 5 | 2020-03-15 | 2022-11-04 |
| Impact of Nuedexta on Bulbar Physiology and Function in ALS dextromethorphan HBr and quinidine sulfate - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Completed | University of Florida | 28 | 2019-07-25 | 2023-03-08 |
| Licorice Botanical Dietary Supplements - Metabolism and Safety in Women Licorice, Alprazolam 2 MG, Caffeine 100 MG - Food-drug Interaction | Phase 1 | Completed | University of Illinois at Chicago | 19 | 2019-04-01 | 2023-05-06 |
| Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects Dextromethorphan HBr, GC4419 - Healthy | Phase 1 | Completed | Galera Therapeutics, Inc. | 13 | 2019-02-10 | 2019-06-19 |
| Add-on Low Dose Dextromethorphan and Memantine in Patients With Amphetamine-type Stimulants Use Disorder dextromethorphan and memantine (DM+MM), Placebos - Stimulants Use Disorder | Phase 1 / Phase 2 | Completed | Tzu-Yun Wang | 85 | 2018-07-24 | 2020-12-10 |
| A Study in Healthy Participants to Evaluate the Effects of Multiple Doses of JNJ-55308942 on Cytochrome P450 Substrate Activity and on the Pharmacokinetics of Levonorgestrel/Ethinyl Estradiol JNJ-55308942 High Dose, JNJ-55308942 Low Dose, Levonorgestrel/Ethinyl Estradiol Fixed Dose combination (FDC) - Healthy | Phase 1 | Completed | Janssen-Cilag International NV | 14 | 2018-06-08 | 2025-04-27 |
| To Investigate the Gastrointestinal Behaviour of Two Triple Combination Products in Healthy Male Volunteers Acetaminophen 650mg+Dextromethorphan 20mg+Phenylephrine 10mg, Acetaminophen 325mg+Dextromethorphan 10mg+Phenylephrine 5mg - Common Cold | Phase 1 | Completed | GlaxoSmithKline | 28 | 2018-03-01 | 2019-06-24 |
| Pharmacokinetic Drug-drug Interaction Study of Encorafenib and Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors losartan, dextromethorphan, caffeine - Advanced Solid Tumors, Metastatic Melanoma | Phase 1 | Completed | Pfizer | 56 | 2018-01-02 | 2024-09-27 |
| Study to Assess the Bioavailability, Pharmacokinetics, Safety, and Tolerability of AVP-923 in Healthy Adult Participants AVP-923 - Healthy Adult Male and Female Volunteers | Phase 1 | Completed | Avanir Pharmaceuticals | 17 | 2017-11-28 | 2018-02-23 |
| A Study to Evaluate the Effect of Oral Doses of JNJ-54175446 on the Inhibition of Cytochrome P450 CYP3A4, CYP2C9, CYP1A2 and CYP2D6 Activity and the Induction of CYP2B6 and CYP2C19 Activity Using a Multiple Probe Substrate Cocktail in Healthy Subjects JNJ-54175446 150 mg, JNJ-54175446 600 mg, Midazolam 2 mg - Healthy | Phase 1 | Completed | Janssen Research & Development, LLC | 16 | 2017-03-14 | 2017-06-08 |
| A Study of Ixekizumab in Participants With Plaque Psoriasis Drug Cocktail, Ixekizumab - Psoriasis | Phase 1 | Completed | Eli Lilly and Company | 28 | 2016-12-22 | 2019-03-12 |
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Alzheimer Disease (2) · Prostatic Neoplasms (2) · Psoriasis (2) · Acquired Immunodeficiency Syndrome (1) · Amyotrophic Lateral Sclerosis (1) · Cognitive Dysfunction (1) · Common Cold (1) · Cough (1) · Depressive Disorder, Major (1) · Depressive Disorder, Treatment-Resistant (1) · Dysphonia (1) · Huntington Disease (1) · Infections (1) · Inflammation (1) · Malaria (1)
Eli Lilly and Company (4) · GlaxoSmithKline (4) · Boehringer Ingelheim (3) · Janssen Research & Development, LLC (3) · Pfizer (3) · Jules Desmeules (2) · Abliva AB (1) · Astellas Pharma Europe B.V. (1) · Astellas Pharma Global Development, Inc. (1) · AstraZeneca (1) · Avanir Pharmaceuticals (1) · Bristol-Myers Squibb (1) · Chonbuk National University Hospital (1) · Cognition Therapeutics (1) · Drugs for Neglected Diseases (1)
United States (26) · Belgium (4) · United Kingdom (3) · Canada (2) · South Korea (2) · Switzerland (2) · China (1) · Germany (1) · Malaysia (1) · Moldova (1) · Netherlands (1) · South Africa (1) · Spain (1) · Taiwan (1)
Alyssa Galley (1) · Anupama Kumar (1) · Catherine A Cukras, MD, PhD (1) · Curtis Chin, MD (1) · Dal-Sik Kim, PhD, MD (1) · Emily Plowman, PhD (1) · George Wilding (1) · Ian M Paul, MD, MSc (1)
PMID 18056558, PMID 22288567, PMID 24722393, PMID 27495955, PMID 27746690, PMID 30584490, PMID 31385617, PMID 32407591, PMID 35135601, PMID 37768317, PMID 38424308, PMID 38878209
2016 (1), 2018 (1), 2019 (1), P30CA014520 (1), U01CA062491 (1)