20 completed, 2 unknown, 1 terminated. 8 Phase 4, 6 Phase 2, 4 Phase 3, 3 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 8 | Completed 7, Terminated 1 |
| Phase 2 | 6 | Completed 5, Unknown 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Not applicable | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
Follow Brimonidine: new trials by email Literature Review of Brimonidine trials Research Report on Brimonidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost Netarsudil, Brimonidine - Normal Tension Glaucoma | Phase 4 | Completed | Westlake Eye Specialists | 100 | 2024-06-13 | 2025-10-22 |
| Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine - Presbyopia, Refractive Error | Phase 3 | Completed | LENZ Therapeutics, Inc | 469 | 2022-12-19 | 2026-05-13 |
| Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic Patients Compound Pilocarpine, Brimonidine, Oxymetazoline, Hyaluronic acid, Bromfenac, Pilocarpine Hydrochloride, Brimonidine Tartrate - Presbyopia | Phase 1 | Unknown | Optall Vision | 11 | 2021-08-10 | 2021-08-19 |
| Compound to Control Presbyopia Symptoms PBO to control presbyopia symptoms - Presbyopia | Phase 1 | Completed | Optall Vision | 11 | 2020-06-01 | 2021-08-19 |
| The Effect of Brimonidine Brimonidine, Tropicamide, Phenylephrine Ophthalmic Product - Intraocular Pressure | Phase 4 | Completed | Wake Forest University Health Sciences | 13 | 2019-07-20 | 2024-02-01 |
| The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Drugs, Investigational - To See the Safety and Efficacy of the Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Patients | Phase 2 | Completed | Chittagong Medical College | 80 | 2018-06-25 | 2019-12-26 |
| Dry Eye Disease Study With Brimonidine Brimonidine, Brimonidine Mono Therapy, sodium carboxymethylcellulose - Dry Eye | Phase 2 | Completed | Ocugen | 84 | 2017-09-06 | 2022-07-06 |
| Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Timolol Maleate, Brimonidine Tartrate - Glaucoma; Drugs, Normal Tension Glaucoma | Phase 4 | Completed | Wills Eye | 35 | 2017-07-10 | 2020-12-31 |
| The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients Alphagan, Phenylephrine, Tropicamide - Intraocular Pressure | Phase 1 | Completed | Wake Forest University Health Sciences | 5 | 2016-09-01 | 2018-08-09 |
| Topical Brimonidine to Reduce Inflammation After IPL-treatment in Patients With Facial Telangiectasias Brimonidine, IPL+air-cooling - Telangiectasias | Phase 4 | Completed | Merete Haedersdal | 19 | 2016-03-13 | 2018-01-05 |
| Mirvaso in Use Study Brimonidine - Rosacea | Phase 4 | Completed | Galderma R&D | 205 | 2014-09-01 | 2022-08-01 |
| Randomized, Double-blind, Multiple-site, Placebo-controlled, Parallel-design Study in Patients With Moderate to Severe Facial Erythema Associated With Rosacea Brimonidine, placebo - Rosacea | Phase 3 | Completed | Actavis Inc. | 462 | 2014-07-01 | 2020-01-14 |
| Trial to Assess the Efficacy of Neuroprotective Drugs Administered Topically to Prevent or Arrest Diabetic Retinopathy COLIRIOBCN070660, Placebo, Brimonidine - Diabetic Retinopathy | Phase 2 / Phase 3 | Completed | BCN Peptides | 450 | 2013-02-01 | 2016-01-12 |
| Effect of Antiglaucoma Agents on Short Term Intraocular Pressure Fluctuations After Intravitreal Bevacizumab Injection Timolol, Brimonidine, Acetazolamide - Intraocular Pressure Change in Intravitreal Injection | Not applicable | Completed | Mashhad University of Medical Sciences | 70 | 2012-02-01 | 2014-05-16 |
| Effect of Alphagan and Xalatan Eye Drops on Corneal Temperature Brimonidine, Latanoprost, Placebo - Primary Vascular Dysregulation | Not applicable | Completed | University Hospital, Basel, Switzerland | 40 | 2011-06-01 | 2013-12-11 |
| Intraocular Pressure (IOP) Lowering Efficacy of Transdermal Brimonidine Therapy Brimonidine, Placebo Lotion - Glaucoma | Phase 2 | Unknown | Nanduri, Padma, M.D., FACS | 22 | 2011-04-01 | 2011-05-02 |
| Aqueous Humor Dynamics and Brimonidine Brimonidine, Artificial tears - Intraocular Pressure | Early Phase 1 | Completed | University of Nebraska | 35 | 2010-08-01 | 2023-11-28 |
| Systemic Bioavailability Study Of Col-118 Administered Topically as a 0.18 % Facial Gel And Brimonidine Ophthalmic Solution 0.2% 0.18% COL-118 facial gel (1.8 mg brimonidine), 0.2% brimonidine ophthalmic solution (0.1 mg brimonidine tartrate/drop), Advanced Eye Relief - Erythematous Rosacea | Phase 2 | Completed | Galderma R&D | 20 | 2008-05-01 | 2021-02-18 |
| Safety and Efficacy of Brimonidine in Patients With Glaucoma or Ocular Hypertension brimonidine - Glaucoma, Ocular Hypertension | Phase 3 | Completed | Allergan | 207 | 2005-01-01 | 2011-05-30 |
| Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise Clonidin, Brimonidine - Ocular Physiology, Regional Blood Flow | Phase 4 | Completed | Medical University of Vienna | 18 | 2004-02-01 | 2007-02-12 |
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Glaucoma (5) · Presbyopia (3) · Diabetic Retinopathy (2) · Low Tension Glaucoma (2) · Rosacea (2) · Dry Eye Syndromes (1) · Eye Diseases (1) · Glaucoma, Open-Angle (1) · Inflammation (1) · Macular Degeneration (1) · Macular Edema (1) · Mydriasis (1) · Myopia (1) · Ocular Hypertension (1) · Refractive Errors (1)
Galderma R&D (2) · Optall Vision (2) · Wake Forest University Health Sciences (2) · Actavis Inc. (1) · Allergan (1) · BCN Peptides (1) · Chittagong Medical College (1) · Federal University of São Paulo (1) · LENZ Therapeutics, Inc (1) · Mashhad University of Medical Sciences (1) · Medical University of Vienna (1) · Merete Haedersdal (1) · Nanduri, Padma, M.D., FACS (1) · Ocugen (1) · University Hospital, Basel, Switzerland (1)
United States (11) · Denmark (2) · Italy (2) · Mexico (2) · Austria (1) · Bangladesh (1) · Brazil (1) · France (1) · Germany (1) · Iran (1) · Portugal (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
Keith Walter, MD (2) · Aline K Sousa, MD (1) · Carol B Toris, PhD (1) · Cesar Alejandro S Galeana (1) · Cesar Alejandro S Galeana, MD (1) · Daniel Lee, MD (1) · James Leyden, M.D. (1) · Jeffrey Sugarman, MD (1) · Josef Flammer, MD (1) · Kris Gambelin, BS (1) · Michael Boone, MD (1) · Nageshwar R Thudi, Ph.D. (1)
PMID 18534052, PMID 24886701, PMID 28663190, PMID 28785768, PMID 33389369
2015 (1)