10 completed. 4 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia LNZ101 (Aceclidine /Brimonidine) ophthalmic solution, LNZ100 (Aceclidine) ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia | Phase 1 | Completed | Corxel Pharmaceuticals | 21 | 2024-03-04 | 2024-04-23 |
| Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Placebo (Vehicle) ophthalmic solution - Presbyopia, Near Vision | Phase 3 | Completed | Corxel Pharmaceuticals | 300 | 2023-09-27 | 2025-03-03 |
| Plasma Pharmacokinetics and Safety of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Subjects With Presbyopia Aceclidine + Brimonidine, Aceclidine - Eye Diseases, Presbyopia | Phase 1 | Completed | LENZ Therapeutics, Inc | 30 | 2023-07-06 | 2023-10-16 |
| Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle - Presbyopia, Near Vision | Phase 3 | Completed | LENZ Therapeutics, Inc | 229 | 2023-03-06 | 2026-10-08 |
| Phase 3 Safety Study of LNZ100 and LNZ101 for the Treatment of Presbyopia Subjects Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle - Presbyopia, Near Vision | Phase 3 | Completed | LENZ Therapeutics, Inc | 362 | 2023-02-21 | 2026-05-13 |
| Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine - Presbyopia, Refractive Error | Phase 3 | Completed | LENZ Therapeutics, Inc | 469 | 2022-12-19 | 2026-05-13 |
| Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle proprietary ophthalmic solution - Presbyopia, Refractive Errors | Phase 2 | Completed | LENZ Therapeutics, Inc | 59 | 2022-08-06 | 2024-09-05 |
| Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Vehicle Proprietary Ophthalmic Solution - Presbyopia, Refractive Errors | Phase 2 | Completed | LENZ Therapeutics, Inc | 68 | 2022-05-05 | 2024-09-05 |
| A Single-Center, Double-Masked Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia Aceclidine+tropicamide combination, Aceclidine, Vehicle - Presbyopia | Phase 2 | Completed | LENZ Therapeutics, Inc | 58 | 2017-04-30 | 2022-09-22 |
| Evaluation of the Efficacy and Safety of PRX-100 in the Treatment of Early to Moderate Presbyopia PRX-100, Placebo - Presbyopia | Phase 2 | Completed | LENZ Therapeutics, Inc | 20 | 2015-09-01 | 2017-10-23 |
Presbyopia (10) · Eye Diseases (7) · Myopia (6) · Refractive Errors (6) · Miosis (1)
Brimonidine Tartrate (5) · aceclidine (5) · Ophthalmic Solutions (2)
United States (8) · China (2)
Kris Gambelin, BS (3) · Alisyn Facemire, BA (2) · Gail Torkildsen, MD (1) · Gloria Sun (1) · Kris Gameblin (1) · Larry Li, Doctor (1)