Time-Restricted Feeding Plus Resistance Training in Active Females: Effects on Body Composition, Muscular Performance and Physiological Variables
| Registry | NCT03404271 |
|---|
| Status | Completed |
|---|
| Phase | Not applicable |
|---|
| Study type | Interventional; randomized, factorial, masking: triple, other |
|---|
| Enrollment | 40 (Actual) |
|---|
| Sponsor | Texas Tech University (Other); collaborators: Metabolic Technologies Inc., Dymatize Enterprises, LLC |
|---|
| Conditions | Healthy Active Females |
|---|
| Interventions | Beta-hydroxy beta-methylbutyrate, Resistance Training, Protein Supplementation, Time-Restricted Feeding (Dietary supplement, other, behavioral) |
|---|
| Dates | start 2018-01-17, primary completion 2018-08-15, completion 2018-08-15, first posted 2018-01-19, last updated 2018-09-12 |
|---|
| Locations | 1 site in United States |
|---|
Related Papers Related Patents Related Grants Related Experts
AI Assistant Save
All trials for Healthy Active Females All trials of Beta-hydroxy beta-methylbutyrate All trials of Resistance Training
-Summary
The objective of this study is to examine the effects of time-restricted feeding (TRF; consuming all calories within an 8-hour period of time each day) and resistance training, with or without the addition of the dietary supplement HMB, on body composition, muscular performance and physiological outcomes in active females.
Expand all sections · Collapse all
+Arms and interventions
| Arm | Type | Interventions | Description |
|---|
| Normal Diet | Placebo comparator | Other: Resistance Training; Dietary Supplement: Protein Supplementation | Participants in the normal diet (ND) group will follow a traditional dietary pattern, consisting of eating breakfast and continuing to eat throughout the day until the evening. Participants in this group will receive placebo capsules. Participants in all groups will follow an identical resistance training program and be provided with whey protein supplements. |
| Time-Restricted Feeding | Experimental | Other: Resistance Training; Dietary Supplement: Protein Supplementation; Behavioral: Time-Restricted Feeding | Participants in the time-restricted feeding (TRF) group will consume all calories within an 8-hour period of time each day. Participants in this group will receive placebo capsules. Participants in all groups will follow an identical resistance training program and be provided with whey protein supplements. |
| Time-Restricted Feeding plus HMB | Experimental | Dietary Supplement: Beta-hydroxy beta-methylbutyrate; Other: Resistance Training; Dietary Supplement: Protein Supplementation; Behavioral: Time-Restricted Feeding | Participants in the time-restricted feeding plus HMB (TRF+HMB) group will consume all calories within an 8-hour period of time each day. Participants in this group will receive HMB capsules. Participants in all groups will follow an identical resistance training program and be provided with whey protein supplements. |
- Beta-hydroxy beta-methylbutyrate (Dietary supplement), also known as HMB: 3 grams per day of the calcium salt form of beta-hydroxy beta-methylbutyrate (HMB).
- Resistance Training (Other): Performing supervised resistance training three times per week.
- Protein Supplementation (Dietary supplement): Consuming a protein supplement daily.
- Time-Restricted Feeding (Behavioral), also known as Intermittent Fasting: Consuming all calories within a specified 8-hour period of time each day.
+Outcome measures
Primary outcomes
- Fat mass [8 weeks]: Assessed using multi-compartment model
- Fat-free mass [8 weeks]: Assessed using multi-compartment model
- Body fat percentage [8 weeks]: Assessed using multi-compartment model
- Upper body muscle hypertrophy [8 weeks]: Muscle thickness of elbow flexor muscles
- Lower body muscle hypertrophy [8 weeks]: Muscle thickness of knee extensor muscles
Secondary outcomes
- Lower body muscular strength [8 weeks]: Assessed by 1RM on leg press
- Lower body muscular power characteristics [8 weeks]: Assessed during vertical jump and isometric squats
- Lower body muscular endurance [8 weeks]: Assessed by repetitions to failure on leg press
- Upper body muscular strength [8 weeks]: Assessed by 1RM on bench press
- Upper body muscular endurance [8 weeks]: Assessed by repetitions to failure on bench press
- Cortisol awakening response [8 weeks]: Assessed via analysis of saliva samples
- Lipid panel [8 weeks]: Measured from fasted blood sample
- Blood glucose [8 weeks]: Measured from fasted blood sample
- Blood insulin [8 weeks]: Measured from fasted blood sample
- Blood C-reactive protein [8 weeks]: Measured from fasted blood sample
- Blood pressure [8 weeks]: Measured using automated device
- Arterial compliance [8 weeks]: Assessed by applanation tonometry
- Resting metabolic rate [8 weeks]: Assessed by indirect calorimetry
- Respiratory quotient [8 weeks]: Assessed by indirect calorimetry
- Mood [8 weeks]: Assessed by questionnaire
- Eating behavior [8 weeks]: Assessed by three-factor eating questionnaire R18
- Sleep quality [8 weeks]: Assessed by Pittsburgh Sleep Quality Index
- Physical activity level [8 weeks]: Assessed by accelerometry.
+Eligibility
Sex: Female, ages: 18 Years to 30 Years, accepts healthy volunteers
Inclusion Criteria:
* Female between 18 and 30 years of age
* Current university affiliation
* Weighing at least 110 pounds
* Generally healthy
* Resistance-trained
* Schedule availability to complete supervised resistance training
* Body fat percentage between 15 and 29%
Exclusion Criteria:
* Pregnant or trying to become pregnant
* Currently breastfeeding
* Any disease, condition or orthopedic limitation that would prevent safe participation in resistance training or time-restricted feeding
* Current smoker
* Presence of pacemaker or other electrical implant
* Allergic to dairy proteins
+Locations (1)
| Facility | City | Country | Status |
|---|
| Texas Tech University | Lubbock, Texas | United States | |
+Publications
- Moro T, Tinsley G, Bianco A, Marcolin G, Pacelli QF, Battaglia G, Palma A, Gentil P, Neri M, Paoli A. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016 Oct 13;14(1):290. doi: 10.1186/s12967-016-1044-0. PMID 27737674
- Tinsley GM, Forsse JS, Butler NK, Paoli A, Bane AA, La Bounty PM, Morgan GB, Grandjean PW. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. Eur J Sport Sci. 2017 Mar;17(2):200-207. doi: 10.1080/17461391.2016.1223173. Epub 2016 Aug 22. PMID 27550719
- Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev. 2015 Oct;73(10):661-74. doi: 10.1093/nutrit/nuv041. Epub 2015 Sep 15. PMID 26374764
- Results publication: Allaf M, Elghazaly H, Mohamed OG, Fareen MFK, Zaman S, Salmasi AM, Tsilidis K, Dehghan A. Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst Rev. 2021 Jan 29;1(1):CD013496. doi: 10.1002/14651858.CD013496.pub2. PMID 33512717
- Results publication: Tinsley GM, Moore ML, Graybeal AJ, Paoli A, Kim Y, Gonzales JU, Harry JR, VanDusseldorp TA, Kennedy DN, Cruz MR. Time-restricted feeding plus resistance training in active females: a randomized trial. Am J Clin Nutr. 2019 Sep 1;110(3):628-640. doi: 10.1093/ajcn/nqz126. PMID 31268131
+Investigators