10 completed, 5 unknown, 2 not yet recruiting, 2 recruiting. 22 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 22 | Completed 10, Unknown 5, Not yet recruiting 2, Recruiting 2, Active not recruiting 1, Terminated 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota. Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine - HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome | Phase 4 | Recruiting | Nanjing First Hospital, Nanjing Medical University | 120 | 2025-04-17 | 2026-04-13 |
| Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 558 | 2024-09-20 | 2025-07-03 |
| Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. esomeprazole, Bismuth, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Unknown | Xijing Hospital of Digestive Diseases | 548 | 2023-11-20 | 2024-09-19 |
| Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus Berberine plus lifestyle intervention, Placebo plus lifestyle intervention - PreDiabetes, Abdominal Obesity | Phase 4 | Active not recruiting | China National Center for Cardiovascular Diseases | 2024 | 2023-10-31 | 2025-12-31 |
| Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals with Obesity and NAFLD Berberine plus lifestyle intervention, Placebo plus lifestyle intervention - Obesity, Obesity, Abdominal | Phase 4 | Completed | China National Center for Cardiovascular Diseases | 337 | 2023-07-06 | 2025-01-29 |
| Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA Berberine, Inulin, Berberine placebo tablets - Type 1 Diabetes Mellitus, Autoimmune Diabetes | Phase 4 | Not yet recruiting | Second Xiangya Hospital of Central South University | 240 | 2022-05-01 | 2022-02-25 |
| Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia Patients Berberine, Metformin - Schizophrenia, Metabolic Syndrome | Phase 4 | Unknown | Tianjin Anding Hospital | 100 | 2021-12-01 | 2022-02-16 |
| Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP) Berberine, Healthy lifestyle intervention - Metabolic Syndrome | Phase 4 | Not yet recruiting | Tang Yida | 5200 | 2021-12-01 | 2021-11-03 |
| Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 300 | 2021-12-01 | 2023-01-31 |
| Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy Berberine, Amoxicillin, Rabeprazole - Dyspepsia, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 524 | 2021-01-07 | 2023-01-31 |
| The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19 Berberine, Montmorrillonite - Berberine, COVID-19 | Phase 4 | Completed | Chinese Medical Association | 76 | 2020-02-08 | 2020-07-21 |
| Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention Berberine, Standard treatment, Aspirin - Coronary Artery Disease, Percutaneous Coronary Intervention | Phase 4 | Recruiting | Peking Union Medical College Hospital | 64 | 2018-09-26 | 2025-11-19 |
| Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy Berberine, Amoxicillin, Esomeprazole - Gastric Ulcer, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 658 | 2018-08-01 | 2019-08-30 |
| Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis berberine, regular treatment - Ulcerative Colitis | Phase 4 | Withdrawn | Xijing Hospital of Digestive Diseases | 2016-11-01 | 2023-02-01 | |
| The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia Berberine; Insulin, Insulin - Hyperglycemia | Phase 4 | Unknown | Guangdong Provincial People's Hospital | 200 | 2016-07-01 | 2016-06-21 |
| Berberine Prevent Contrast-induced Nephropathy in Patients With Diabetes Berberine - Diabetes Mellitus, Chronic Kidney Disease | Phase 4 | Completed | Nanjing First Hospital, Nanjing Medical University | 800 | 2016-07-01 | 2022-03-29 |
| Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Prediabetes Berberine, Metformin - Prediabetes, Impaired Fasting Glucose | Phase 4 | Unknown | University of Guadalajara | 28 | 2016-03-01 | 2023-05-23 |
| Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Berberine, clarithromycin, Bismuth - Gastritis, Peptic Ulcer | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 566 | 2015-12-01 | 2017-01-18 |
| Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Berberine, Bismuth, esomeprazole - Gastritis, Peptic Ulcer | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 612 | 2014-11-01 | 2015-09-03 |
| Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Association low-dose statin and nutraceuticals - Coronary Artery Disease | Phase 4 | Unknown | University of Roma La Sapienza | 100 | 2013-11-01 | 2013-12-05 |
Showing 20 of 22. Sign in to see all of them.
Dyspepsia (3) · Gastritis (3) · Metabolic Syndrome (3) · Coronary Artery Disease (2) · Diabetes Mellitus (2) · Dyslipidemias (2) · Hyperglycemia (2) · Obesity, Abdominal (2) · Peptic Ulcer (2) · Prediabetic State (2) · Stomach Neoplasms (2) · Atherosclerosis (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Colitis, Ulcerative (1)
Xijing Hospital of Digestive Diseases (8) · China National Center for Cardiovascular Diseases (2) · Nanjing First Hospital, Nanjing Medical University (2) · Chinese Medical Association (1) · Comitato Etico di Area Vasta Sud Est (1) · Guangdong Provincial People's Hospital (1) · Peking Union Medical College Hospital (1) · Second Xiangya Hospital of Central South University (1) · Tang Yida (1) · Tianjin Anding Hospital (1) · University of Guadalajara (1) · University of Roma La Sapienza (1) · Wenzhou Medical University (1)
China (18) · Italy (1) · Mexico (1)
Haibo Zhang, MD (2) · Jing Li, PhD (2) · Yongquan Shi, Ph. D (2) · Jifei Tang, MD (1) · Shaoliang Chen (1) · Weiping Xiong, M.D. (1) · Wenkui Yu, M.D. (1) · Yang Xiao, MD/PhD (1) · Yi-Da Tang, MD, PhD (1) · Zhenyu Liu, M.D. (1)
PMID 26649075, PMID 32171076, PMID 32213556, PMID 32312790, PMID 32348007, PMID 35784546, PMID 41543854