10 completed, 7 terminated, 6 unknown, 1 not yet recruiting. 24 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 24 | Completed 10, Terminated 7, Unknown 6, Not yet recruiting 1 |
| Phase 2 | 7 | Completed 3, Terminated 2, Unknown 2 |
Follow Amitriptyline: new trials by email Literature Review of Amitriptyline trials Research Report on Amitriptyline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Amitriptyline for Repetitive Behaviors in Autism Spectrum Disorders amitriptyline - Autism Spectrum Disorder, Repetitive Compulsive Behavior | Phase 3 | Terminated | University of Missouri, Kansas City | 1 | 2023-11-01 | 2025-05-30 |
| A Multidisciplinary, Multimodal Bundled Care Approach to Chronic Pelvic Pain Multimodal Bundle Drugs, Operative Cystoscopy, Behavioral health consultation/therapy - Interstitial Cystitis, Levator Spasm | Phase 3 | Terminated | Jocelyn Fitzgerald | 26 | 2022-12-06 | 2026-04-01 |
| Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint Citalopram 10 MG, Amitriptyline, Bite Splint - Muscle Type Temporomandibular Disorders, Myofascial Pain of the Masticatory Muscles | Phase 2 / Phase 3 | Unknown | University of Coimbra | 80 | 2021-03-01 | 2021-03-02 |
| Treatment of Neuropathic Pain in Leprosy Amitriptyline, Placebo oral capsule, Tramadol - Pain, Neuropathic, Leprosy | Phase 3 | Unknown | University of Sao Paulo | 102 | 2017-03-01 | 2022-02-23 |
| Physical Therapy as Adjuvant Treatment of Vulvodynia: a Randomized Controled Trial Amitriptyline, Kinesiotherapy, IC (Quark) - Vulvodynia | Phase 3 | Unknown | University of Campinas, Brazil | 58 | 2016-07-01 | 2016-08-18 |
| Treatment of Chronic Laryngitis With Amitriptyline Amitriptyline, Placebo - Laryngeal Diseases | Phase 2 / Phase 3 | Terminated | Boston Medical Center | 6 | 2016-04-01 | 2021-10-29 |
| Preemptive Analgesia With Amitryptyline for Prevention of Pain in Women After Hysterectomy Amitriptyline, Placebo - Pain, Postoperative | Phase 3 | Completed | University of Campinas, Brazil | 150 | 2015-06-01 | 2018-11-26 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Alternative Dosing Regimens in the Pharmacotherapy of Insomnia Amitriptyline, Zolpidem, Placebo - Insomnia | Phase 3 | Terminated | Philipps University Marburg | 23 | 2014-05-01 | 2018-03-09 |
| Novel Topical Therapies for the Treatment of Genital Pain Amitriptyline, Baclofen, Ketoprofen - Female Genital Diseases | Phase 2 / Phase 3 | Completed | University of Rochester | 9 | 2013-11-01 | 2016-07-15 |
| Trial of the Treatment of Chronic Laryngitis With Amitryptiline Amitriptyline, Placebo - Laryngeal Diseases, Chronic Laryngeal Neuropathy | Phase 2 / Phase 3 | Terminated | Boston Medical Center | 30 | 2013-09-01 | 2016-11-30 |
| The Childhood and Adolescent Migraine Prevention Study Amitriptyline, Topiramate, Placebo - Migraine, Migraine Disorders | Phase 3 | Terminated | Children's Hospital Medical Center, Cincinnati | 488 | 2012-06-01 | 2017-08-10 |
| Immune-Pineal Axis Function in Fibromyalgia Melatonin and Placebo, Amitriptyline and Placebo, Melatonin and Amitriptylin - Fibromyalgia | Phase 2 / Phase 3 | Unknown | Hospital de Clinicas de Porto Alegre | 66 | 2010-06-01 | 2014-01-22 |
| Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine Amitriptyline, Melatonin, Placebo - Migraine | Phase 3 | Completed | Hospital Israelita Albert Einstein | 192 | 2010-05-01 | 2015-12-30 |
| Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer amitriptyline, pregabalin - Cancer, Neuralgia | Phase 3 | Unknown | Radboud University Medical Center | 130 | 2008-09-01 | 2009-02-05 |
| Neuropathic Pain Caused by Radiation Therapy topical amitriptyline 2%, ketamine 1%, and lidocaine 5% in pluronic lecitine organogel(AKL in PLO gel) - Neuropathic Pain Secondary to Radiation Therapy | Phase 3 | Completed | British Columbia Cancer Agency | 22 | 2008-04-01 | 2011-06-22 |
| Effects of Pregabalin, Duloxetine & Amitriptyline on Pain & Sleep Pregabalin, Duloxetine, Amitriptyline - Diabetes Mellitus, Peripheral Neuropathies | Phase 2 / Phase 3 | Completed | University of Surrey | 90 | 2007-02-01 | 2009-11-17 |
| Pediatric Chronic Headache Trial Coping Skills Training, Headache Education, Amitriptyline - Headache | Phase 3 | Unknown | Children's Hospital Medical Center, Cincinnati | 132 | 2006-10-01 | 2011-04-25 |
| Functional Dyspepsia Treatment Trial Amitriptyline, Escitalopram, Placebo - Dyspepsia and Other Specified Disorders of Function of Stomach | Phase 2 / Phase 3 | Completed | Mayo Clinic | 292 | 2006-10-01 | 2014-07-25 |
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Headache (3) · Agnosia (2) · Cystitis, Interstitial (2) · Depression (2) · Laryngeal Diseases (2) · Migraine Disorders (2) · Neuralgia (2) · Pain (2) · Pain, Postoperative (2) · Abdominal Pain (1) · Anxiety Disorders (1) · Autism Spectrum Disorder (1) · Autistic Disorder (1) · Dementia (1) · Depressive Disorder (1)
Boston Medical Center (2) · Children's Hospital Medical Center, Cincinnati (2) · University of Campinas, Brazil (2) · AstraZeneca (1) · British Columbia Cancer Agency (1) · Central Institute of Mental Health, Mannheim (1) · Hannover Medical School (1) · Hospital Israelita Albert Einstein (1) · Hospital de Clinicas de Porto Alegre (1) · Jocelyn Fitzgerald (1) · Mayo Clinic (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Philipps University Marburg (1) · Radboud University Medical Center (1) · The Hospital for Sick Children (1)
United States (10) · Brazil (5) · Canada (5) · Germany (4) · Australia (1) · Belgium (1) · Czechia (1) · Finland (1) · France (1) · Netherlands (1) · Norway (1) · Poland (1) · Portugal (1) · Romania (1) · South Africa (1)
J. Pieter Noordzij, MD (2) · Adrienne D Bonham, MD (1) · Andrew Bishara, MD (1) · Andrew D. Hershey, MD, PhD (1) · Bettina K Doering, Dr. (1) · Bincy P Abraham, M.D., M.S. (1) · Brian E. Lacy, M.D., Ph.D. (1) · Bruno M Sousa (1) · Carmen Schade-Brittinger (1) · Charlene M Prather, M.D. (1) · Christopher S. Coffey, PhD (1) · Colin P Howden, M.D. (1) · Daniel Andrade, PhD (1) · Dr D Coppini (1) · Dr D Kerr (1)
PMID 17012991, PMID 18981976, PMID 19358791, PMID 20059663, PMID 20303115, PMID 20952454, PMID 21593054, PMID 21818576, PMID 22343090, PMID 22991449, PMID 23277262, PMID 23497790, PMID 23594025, PMID 23672772, PMID 24067192, PMID 24108148, PMID 24175721, PMID 24368463, PMID 24816198, PMID 25052847, PMID 25761431, PMID 25921377, PMID 26474010, PMID 26992129, PMID 27045258, PMID 27150263, PMID 27788026, PMID 28108386, PMID 29199141, PMID 32734597, PMID 34028656, PMID 34404270, PMID 34865085, PMID 36951987, PMID 42152617
R01NS050536 (1), U01DK065209 (1), U01DK065713 (1), U01NS076788 (1)