16 completed, 6 unknown, 4 recruiting, 4 terminated. 31 Phase 2, 7 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 31 | Completed 16, Unknown 6, Recruiting 4, Terminated 4, Active not recruiting 1 |
| Phase 3 | 7 | Completed 3, Terminated 2, Unknown 2 |
| Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Amitriptyline for IBS-like Symptoms in Quiescent Crohn's Disease Amitriptyline, Placebo - Quiescent Crohn's Disease (CD) | Phase 2 | Recruiting | University of Michigan | 100 | 2026-06-03 | 2026-06-05 |
| Mesotherapy Treatment of Irritable Bowel Syndrome Mesotherapy with mesocaine, thiocolchicoside, amitriptyline, magnesium pidolate - Inflammatory Bowel Diseases | Phase 2 | Active not recruiting | Polyclinique de l'Europe | 27 | 2024-02-28 | 2025-05-31 |
| Evaluating Use of Topical Imipramine and Amitriptyline in Reducing Ultraviolet B Light-Induced Redness in Patients With Rosacea Imipramine, Amitriptyline, Vehicle - Rosacea | Phase 2 | Recruiting | Wright State University | 48 | 2024-02-27 | 2026-02-18 |
| Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy Duloxetine alone, Duloxetine augmented with gabapentin, Duloxetine augmented with amitriptyline (as combined therapy) - Neuropathy in Cacer Patien | Phase 2 | Unknown | Beni-Suef University | 160 | 2023-10-10 | 2024-04-16 |
| EASE (Efficacy of ATX01 Study in Erythromelalgia) Amitriptyline Hydrochloride, Placebo - Erythromelalgia | Phase 2 | Completed | AlgoTherapeutix | 14 | 2023-06-14 | 2024-04-18 |
| Efficacy of Two Doses of Duloxetine & Amitriptyline in Interstitial Lung Disease-related Cough Amitriptyline 25 MG, Amitriptyline 50 MG, Duloxetine 30 MG - Interstitial Lung Disease | Phase 2 | Recruiting | Mayo Clinic | 25 | 2021-11-01 | 2026-01-21 |
| Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG - Refractory Chronic Cough | Phase 2 | Recruiting | Mayo Clinic | 50 | 2021-11-01 | 2026-01-21 |
| Study to Evaluate the Interest of Qutenza in Patients With Head and Neck Cancer in Remission and With Sequelae Neuropathic Pain. Capsaïcin patch (Qutenza®), Amitriptyline (Laroxyl®) - Head and Neck Cancer | Phase 2 | Completed | Institut Claudius Regaud | 13 | 2021-04-28 | 2026-04-14 |
| Myofascial Pain Patients' Response to the Administration of Low Doses of Amitriptyline and Citalopram Compared With the Use of Bite Splint Citalopram 10 MG, Amitriptyline, Bite Splint - Muscle Type Temporomandibular Disorders, Myofascial Pain of the Masticatory Muscles | Phase 2 / Phase 3 | Unknown | University of Coimbra | 80 | 2021-03-01 | 2021-03-02 |
| Mind and Body Approaches to Pain Reduction in Youth With Migraine Cognitive Behavioral Therapy (CBT), Placebo, Amitriptyline - Headache, Migraine, Migraine | Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 132 | 2018-10-02 | 2025-08-26 |
| Amitriptyline in Treating Hypoglycemia Amitriptyline, Placebo - Type1 Diabetes Mellitus, Hypoglycemia Unawareness | Phase 2 | Terminated | University of Utah | 2 | 2018-08-01 | 2019-07-22 |
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine Ketamine Hydrochloride, Amitriptyline Hydrochloride, Lidocaine Hydrochloride - Pruritus | Phase 2 | Terminated | Gil Yosipovitch | 13 | 2017-05-23 | 2019-07-02 |
| Treatment of Chronic Laryngitis With Amitriptyline Amitriptyline, Placebo - Laryngeal Diseases | Phase 2 / Phase 3 | Terminated | Boston Medical Center | 6 | 2016-04-01 | 2021-10-29 |
| Trial of Laparoscopic Cholecystectomy vs. Non-operative Treatment for Gallbladder Dyskinesia Laparoscopic Cholecystectomy, amitriptyline, low-fat and low cholesterol diet - Gallbladder Dyskinesia | Phase 2 | Unknown | CAMC Health System | 60 | 2014-02-01 | 2015-03-05 |
| Novel Topical Therapies for the Treatment of Genital Pain Amitriptyline, Baclofen, Ketoprofen - Female Genital Diseases | Phase 2 / Phase 3 | Completed | University of Rochester | 9 | 2013-11-01 | 2016-07-15 |
| Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD) ETS6103 (low dose), ETS6103 (high dose), Amitriptyline - Major Depressive Disorder | Phase 2 | Completed | e-Therapeutics PLC | 164 | 2013-10-01 | 2017-01-11 |
| Trial of the Treatment of Chronic Laryngitis With Amitryptiline Amitriptyline, Placebo - Laryngeal Diseases, Chronic Laryngeal Neuropathy | Phase 2 / Phase 3 | Terminated | Boston Medical Center | 30 | 2013-09-01 | 2016-11-30 |
| Amitriptyline to Prevent Headache After Traumatic Brain Injury Amitriptyline - Brain Injuries, Post-Traumatic Headache | Phase 2 | Completed | University of Washington | 50 | 2013-04-01 | 2024-09-19 |
| Newer Antidepressants in Combination With Pregabalin for Fibromyalgia Syndrome Amitriptyline, Venlafaxine, Paroxetine - Fibromyalgia | Phase 1 / Phase 2 | Completed | Mansoura University | 75 | 2013-02-01 | 2015-05-22 |
| Amitriptyline Regarding Nimesulide in Acute Idiopathic Adhesive Capsulitis amitriptyline - Adhesive Capsulitis | Phase 2 | Completed | Universidade do Sul de Santa Catarina | 34 | 2011-02-01 | 2012-01-31 |
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Fibromyalgia (3) · Chronic Cough (2) · Cough (2) · Cystic Fibrosis (2) · Laryngeal Diseases (2) · Neuralgia (2) · Pain (2) · Peripheral Nervous System Diseases (2) · AIDS-Related Complex (1) · Abdominal Pain (1) · Acquired Immunodeficiency Syndrome (1) · Asthma (1) · Biliary Dyskinesia (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1)
Mayo Clinic (3) · Boston Medical Center (2) · AlgoTherapeutix (1) · Ann Davis, PhD, MPH, ABPP (1) · Beni-Suef University (1) · CAMC Health System (1) · Centro Medico Teknon (1) · Children's Hospital Medical Center, Cincinnati (1) · EpiCept Corporation (1) · Gil Yosipovitch (1) · Hospital de Clinicas de Porto Alegre (1) · Institut Claudius Regaud (1) · Mansoura University (1) · National Center for Complementary and Integrative Health (NCCIH) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1)
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