11 completed, 3 terminated, 1 not yet recruiting, 1 recruiting. 17 Phase 2, 4 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 11, Terminated 3, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 1 | Not yet recruiting 1 |
Follow alpha-Tocopherol: new trials by email Literature Review of alpha-Tocopherol trials Research Report on alpha-Tocopherol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Pneumonitis Prevention Protocol Using Pentoxifylline and α-tocopherol In Stage III Non-Small Cell Lung Cancer Patients Undergoing Chemoradiation Pentoxifylline, Placebo, α-Tocopherol - Non-Small Cell Lung Cancer, Radiation Induced Lung Injury (RILI) | Phase 2 | Recruiting | University Health Network, Toronto | 150 | 2026-06-15 | 2026-08-06 |
| Vitamin E Efficacy in HI/HA Vitamin E - Hyperinsulinism-Hyperammonemia Syndrome | Phase 2 | Withdrawn | Children's Hospital of Philadelphia | 2022-11-01 | 2022-12-13 | |
| Vitamin E Dosing Study Vitamin E, Placebo - Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis | Phase 2 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 200 | 2022-08-05 | 2026-05-14 |
| Effect of Alpha Tocopherol and Psyllium on Lipid Levels in Dyslipidaemia Patients Alpha tocopherol, Combination therapy (Alpha Tocopherol and Psyllium husk), Placebo Control - Dyslipidaemia | Phase 2 | Completed | NUR International University | 60 | 2022-06-15 | 2026-05-27 |
| Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer Atorvastatin, Pentoxifylline, Vitamin E Compound - Male Erectile Disorder, Prostate Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 14 | 2019-11-20 | 2023-10-17 |
| The Efficacy, Safety and Tolerability of Oral LPCN 1144 in Subjects With Nonalcoholic Steatohepatitis LPCN 1144 Formulation A, LPCN 1144 Formulation B, Placebo - Nonalcoholic Steatohepatitis (NASH) | Phase 2 | Completed | Lipocine Inc. | 56 | 2019-08-27 | 2023-12-14 |
| Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly. Ascorbic Acid, Alpha tocopherol, PLACEBO - Depression | Phase 2 | Completed | Yolanda de Diego Otero | 50 | 2014-10-01 | 2018-03-01 |
| Effect of Antioxidant Vitamins on Coagulopathy and Nosocomial Pneumonia After Severe Trauma Vitamin C, Vitamin E, Saline (for Vitamin C) - Coagulopathy, Nosocomial Pneumonia | Phase 2 | Terminated | University of Alabama at Birmingham | 11 | 2013-05-01 | 2017-03-29 |
| Vitamin E Supplementation in Burned Patients Vitamin E - Burn | Phase 2 / Phase 3 | Completed | The University of Texas Medical Branch, Galveston | 27 | 2013-02-01 | 2026-07-20 |
| Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E), Placebo - Fragile X Syndrome | Phase 2 | Completed | Yolanda de Diego Otero | 30 | 2010-12-01 | 2015-04-14 |
| Type 2 Diabetes Haptoglobin Phenotype and Vitamin E Vitamin E (d-alpha-tocopheryl acetate), Placebo - Diabetes Mellitus Type 2 | Phase 2 / Phase 3 | Completed | Technion, Israel Institute of Technology | 90 | 2009-01-01 | 2011-01-11 |
| Herbal Therapy for Treatment of Recurrent Prostate Cancer Prostate Health Cocktail - Prostate Cancer | Phase 2 | Completed | University of Southern California | 43 | 2008-07-06 | 2017-04-20 |
| Effect of Vitamin E on Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Vitamin treatment (alpha tocopherol plus ascorbic acid), Placebo - Inflammation, Fibrosis | Phase 2 / Phase 3 | Completed | Bambino Gesù Hospital and Research Institute | 90 | 2003-01-01 | 2008-04-09 |
| The Use of Pentoxifylline and Vitamin E in the Treatment of Late Radiation Related Injuries pentoxifylline, α-Tocopherol - Wounds and Injuries | Phase 2 | Terminated | University Health Network, Toronto | 50 | 2002-07-01 | 2010-08-13 |
| The Use of Pentoxifylline and Vitamin E in the Treatment of Chronic Breast Pain pentoxifylline, alpha-Tocopherol - Breast Neoplasms | Phase 2 | Terminated | University Health Network, Toronto | 48 | 2002-07-01 | 2010-08-11 |
| VEAPS: Vitamin E Atherosclerosis Prevention Study DL-alpha-tocopherol - Atherosclerosis | Phase 2 / Phase 3 | Completed | National Institute on Aging (NIA) | 353 | 1996-07-01 | 2009-12-11 |
Non-alcoholic Fatty Liver Disease (3) · Inflammation (2) · Prostatic Neoplasms (2) · Anus Neoplasms (1) · Anxiety Disorders (1) · Atherosclerosis (1) · Autistic Disorder (1) · Behavioral Symptoms (1) · Breast Neoplasms (1) · Burns (1) · Carcinoma, Non-Small-Cell Lung (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Dyslipidemias (1) · Erectile Dysfunction (1)
University Health Network, Toronto (3) · Yolanda de Diego Otero (2) · Bambino Gesù Hospital and Research Institute (1) · Children's Hospital of Philadelphia (1) · Lipocine Inc. (1) · M.D. Anderson Cancer Center (1) · NUR International University (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · National Institute on Aging (NIA) (1) · Technion, Israel Institute of Technology (1) · The University of Texas Medical Branch, Galveston (1) · University of Alabama at Birmingham (1) · University of Nebraska (1) · University of Southern California (1)
United States (9) · Canada (3) · Spain (2) · Israel (1) · Italy (1) · Pakistan (1)
Wilfred Levin, MD (2) · Andrew Levy, MD PhD (1) · Anthony DelConte (1) · Arun Sanyal, MD (1) · Chad Tang (1) · Chi P Lin, MD (1) · Elizabeth A Rosenfeld, MD (1) · Howard N. Hodis, MD (1) · Jean-Francois Pittet, M.D. (1) · Jeffrey Kerby, M.D., Ph.D. (1) · Linda E Sousse, PhD, MBA (1) · Lucia M Perez Costillas, MD PhD (1) · Lucia M Perez-Costillas, MD PhD (1) · Perenlei Enkhbaatar, MD, PhD (1) · Shany Blum, MD PhD (1)
PMID 12234947, PMID 17206944, PMID 21722898, PMID 25187257, PMID 32312759
2009 (1), R01AG013860 (1), U01DK061713 (1), U01DK061718 (1), U01DK061728 (1), U01DK061731 (1), U01DK061732 (1), U01DK061734 (1), U01DK061737 (1), U01DK061738 (1), U24DK061730 (1)