59 completed, 5 not yet recruiting, 3 recruiting, 2 terminated. 45 Not applicable, 8 Phase 4, 3 Phase 1, 3 Phase 2, 3 Phase 3.
Follow Wrinkles: new trials by email Literature Review of Wrinkles trials Research Report on Wrinkles
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Evaluation of a Multi-functional Beauty Device on Cosmetic Skin Outcomes Multi-functional Home-use Beauty Device, Topical Skincare Serum, Skincare Mask - Skin Appearance, Skin Texture | Not applicable | Recruiting | APR Co., Ltd. | 50 | 2026-09-09 | 2026-10-13 |
| Poly-L-lactic Acid (PLLA) Injection for Neck Skin Laxity: A Pilot Study Poly-L-Lactic Acid (Sculptra) injection - Skin Aging, Wrinkles | Not applicable | Not yet recruiting | Institute of Dermatology, Thailand | 10 | 2026-07-01 | 2026-07-08 |
| Effect of Single Facial Acupuncture on Dermal Structure and Appearance Satisfaction Facial Rejuvenation Acupuncture (FRA) - Facial Aging, Wrinkles | Not applicable | Recruiting | Far Eastern Memorial Hospital | 60 | 2026-06-11 | 2026-06-24 |
| Prospective Clinical Evaluation of the Safety and Performance of the Aesthetic Medical Device MEC REGENERATE® (Injectable Recombinant Collagen-based Product) Treatment with experimental device - Laxity; Skin, Volume Deficiency in the Mid-Face | Not applicable | Not yet recruiting | 303 Pharma s.r.l. | 20 | 2026-03-01 | 2026-02-17 |
| Post-market Clinical Follow-up (PMCF) Study of Safety and Performance of 502-01 AnGelHA 2 Wrinkles | Recruiting | Glyance | 87 | 2026-02-08 | 2026-05-28 | |
| Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects. Standardized Saffron Extract (Crocus Sativus L) 10 mg Capsule, Placebo (capsules containing Maltodextrin, Calcium carbonate, Sunset yellow, Maize starch, Mg Stearate, Talc) - Wrinkles, Fine Lines | Not applicable | Not yet recruiting | NovoBliss Research Pvt Ltd | 50 | 2026-01-01 | 2026-01-07 |
| A Clinical Study to Test the Safety and Effectiveness of Pinorox® for Improving Visible Signs of Facial Aging Such as Wrinkles, Fine Lines, and Dark Spots. Topical Cream containing 0.1% Pinorox®, Topical Cream containing 1% Pinorox®, Placebo (Base Cream) - Fine Lines, Wrinkles | Not applicable | Completed | NovoBliss Research Pvt Ltd | 81 | 2025-10-16 | 2026-08-05 |
| PER-SAF_PDOS (Performance and Safety of Polydioxanone Suture) PDO suture - Wrinkles, Anti Aging | Not applicable | Not yet recruiting | 21 Century Medical Co., Ltd. | 50 | 2025-09-01 | 2025-07-16 |
| Evaluation of the Efficacy of a Cosmetic Light Mask LED Light Treatment, Vibration Only - Fine Lines, Contour | Not applicable | Completed | Therabody, Inc. | 115 | 2025-05-05 | 2025-09-09 |
| Quantified Evaluation of Whole Face 8-points Supra-periosteum High Molecular Weight Hyaluronic Acid Injection in Asian Wrinkles | Not yet recruiting | Chang Chang Cheng | 25 | 2025-03-20 | 2025-03-13 | |
| The Effect of 16-week Dietary Intake of Food Supplements Containing Collagen and MSM on Skin ColMSM-HL, Placebo syrup, ColMSM-LH - Dermis Density, Wrinkles | Not applicable | Completed | VIST - Faculty of Applied Sciences | 139 | 2025-01-27 | 2025-10-02 |
| A Clinical Investigation Comparing the Safety and Performance of RefillHA Solid With Hydryalix Ultra Deep Lidocaine for the Correction of Moderate-to-severe Nasolabial Folds Wrinkles, Folds | Completed | Glyance | 12 | 2024-12-08 | 2026-08-19 | |
| Safety and Efficacy Evaluation of High Intensity Focused Ultrasound Device in Eyebrow Lifting HIFU treatment with ULTRAFOMER MPT - Skin Laxity, Wrinkles | Not applicable | Completed | CLASSYS Inc. | 180 | 2024-11-18 | 2026-05-15 |
| Safety and Efficacy Evaluation of the Monopolar Radiofrequency Device for the Improvement of Facial Wrinkles Radiofrequency (RF) Treatment with Volnewmer, Radiofrequency (RF) Treatment with Thermage CPT - Facial Wrinkles, Anti-Aging | Not applicable | Completed | CLASSYS Inc. | 284 | 2024-09-29 | 2026-05-04 |
| Single-Blind, Investigational Device Exemption Paired-Design, Non-Inferiority Trial With Confirmation for the Assessment of the Efficacy and Safety of a Universal Electrosurgical Device for Temporary Improvement of Mild and Moderate Wrinkles Around Both Eye Corners and Both Cheek Folds 10THERMA, Thermage FLX - Wrinkles | Not applicable | Completed | TENTECH INC. | 80 | 2024-05-10 | 2026-03-12 |
| Post Market Non-Interventional Study of Safety and Performance of RefillHA Volume Wrinkles | Completed | Glyance | 78 | 2024-01-25 | 2026-01-09 | |
| Pilot Evaluation of the Cynosure Potenza™ System for Treatment of Cosmetic Dermatologic Skin Conditions Potenza, Icon - Wrinkles, Scars | Not applicable | Completed | Cynosure, Inc. | 20 | 2023-08-17 | 2025-08-28 |
| The Effect of 16-week Dietary Intake of Food Supplements Containing Collagen on Dermis Density and Other Skin Parameters CP5HA, Placebo syrup, CP5 - Dermis Density, Wrinkles | Not applicable | Completed | VIST - Faculty of Applied Sciences | 87 | 2023-02-13 | 2023-12-11 |
| A Clinical Study Evaluating the Efficacy and Tolerability of a Topical Facial Treatment For Facial Rejuvenation Gentle Cleanser, Facial Moisturizer, sunscreen SPF 30 - Fine Lines, Wrinkles | Not applicable | Completed | Revision Skincare | 32 | 2022-01-11 | 2024-10-08 |
| The Effect of 12-week Dietary Intake of Food Supplements Containing Collagen on Dermis Density and Other Skin Parameters Investigational product 1, Placebo syrup, Investigational product 2 - Dermis Density, Wrinkles | Not applicable | Completed | VIST - Faculty of Applied Sciences | 109 | 2021-10-11 | 2023-02-02 |
Showing 20 of 73. Sign in to see all of them.
Cutis Laxa (11) · Cicatrix (2) · Erythema (2) · Patient Satisfaction (2) · Striae Distensae (2) · Facies (1) · Hyperpigmentation (1) · Lipodystrophy (1) · Rosacea (1) · Skin Diseases (1)
Skin and Connective Tissue Diseases (17) · Skin Diseases (16) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Connective Tissue Diseases (11) · Genetic Diseases, Inborn (11) · Skin Diseases, Genetic (11) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (4) · Skin Manifestations (4) · Pathologic Processes (3) · Behavior (2) · Fibrosis (2) · Health Behavior (2) · Treatment Adherence and Compliance (2) · Disease Attributes (1)
Botulinum Toxins, Type A (7) · Botulinum Toxins (2) · Injections (2) · Lasers, Solid-State (2) · Sunscreening Agents (2) · Therapeutics (2) · 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt (1) · Calcium Carbonate (1) · Collagen (1) · Cryotherapy (1) · Hyaluronic Acid (1) · Juvéderm (1) · Laser Therapy (1) · Lasers (1) · Lycopene (1)
VIST - Faculty of Applied Sciences (6) · Galderma R&D (5) · Cynosure, Inc. (4) · Glyance (3) · Northwestern University (3) · Revision Skincare (3) · Ulthera, Inc (3) · Alma Lasers Inc. (2) · CLASSYS Inc. (2) · Home Skinovations Ltd. (2) · LG Life Sciences (2) · NovoBliss Research Pvt Ltd (2) · Seoul National University Hospital (2) · University of California, Davis (2) · 21 Century Medical Co., Ltd. (1)
United States (35) · Slovenia (4) · Brazil (3) · Israel (3) · South Korea (3) · Canada (2) · China (2) · Germany (2) · Italy (2) · Thailand (2) · India (1) · Philippines (1) · Singapore (1) · Taiwan (1)
Murad Alam, MD (3) · Arielle NB Kauvar, MD (2) · ChangSik Pak, Bachelor (2) · Janko Zmitek, PhD (2) · Katja Zmitek, PhD (2) · Nayan Patel (2) · Adele Sparavigna, Medical Doc (1) · Alessandro Bizzari, ElEn (1) · Alexandre Frederico, Doctor (1) · Alicia Barba, MD (1) · Allen Gabriel, MD (1) · Ana Claudia Fedi (1) · Andrew Alexis, MD (1) · Anthony P Sclafani, MD (1)
PMID 11083570, PMID 12752527, PMID 12786700, PMID 15857456, PMID 16364234, PMID 18377617, PMID 18489289, PMID 26850796, PMID 29296569, PMID 31896400, PMID 32955913, PMID 35403786, PMID 35675051, PMID 39722645, PMID 40193060, PMID 9935084