5 completed, 3 unknown, 1 not yet recruiting, 1 recruiting. 5 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 5 | Completed 1, Not yet recruiting 1, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Ventricular Outflow Obstruction, Left: new trials by email Literature Review of Ventricular Outflow Obstruction, Left trials Research Report on Ventricular Outflow Obstruction, Left
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices SESAME Procedure - Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 200 | 2026-11-01 | 2026-10-27 |
| Positron Emission Tomography to Assess the Effect of Camzyos on Ischaemia in HOCM: PEACH Trial Camzyos (Mavacamten) - Hypertrophic Obstructive Cardiomyopathy \(HOCM\), Left Ventricular Outflow Tract Obstruction | Not applicable | Recruiting | University of Manchester | 75 | 2026-03-26 | 2026-05-22 |
| Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy mavacamten - Hypertrophic Cardiomyopathy (HCM), Obstructive Hypertrophic Cardiomyopathy (oHCM) | Completed | Chinese Academy of Medical Sciences, Fuwai Hospital | 222 | 2024-01-01 | 2026-04-17 | |
| A Study to Evaluate the Effects of Mavacamten in Healthy Participants Mavacamten - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 84 | 2023-02-20 | 2023-10-12 |
| Comparison of Squat-to-Stand Maneuver With Amyl Nitrite, Valsalva, and Exercise Stress Echocardiography in Inducing Latent Left Ventricular Outflow Obstruction in Hypertrophic Cardiomyopathy Squat-to-stand maneuver, Amyl nitrite inhalation, Valsalva - Hypertrophic Cardiomyopathy, Hypertrophic Obstructive Cardiomyopathy | Not applicable | Withdrawn | Mayo Clinic | 2021-11-01 | 2022-01-11 | |
| Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy Metoprolol - Hypertrophic Cardiomyopathy | Phase 4 | Completed | University Hospital, Motol | 22 | 2020-03-05 | 2023-05-10 |
| Reverse Remodeling After PTSMA in Severe But Asymptomatic LVOT Obstruction PTSMA - HOCM, Hypertrophic Obstructive Cardiomyopathy, LVOTO - Left Ventricular Outflow Tract Obstruction | Not applicable | Unknown | St. Antonius Hospital | 15 | 2020-01-21 | 2021-09-16 |
| Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies BNP blood sample test, Electrocardiogram, Holter ECG - Hypertrophic Cardiomyopathy, Endothelial Dysfunction | Not applicable | Completed | University Hospital, Bordeaux | 40 | 2019-10-22 | 2026-06-01 |
| Polish Registry of Common Carotid Artery Access for TAVI Transcatheter Aortic Valve Implantation (TAVI) - Aortic Valve Stenosis, Ventricular Outflow Obstruction, Left | Unknown | Medical University of Warsaw | 200 | 2018-01-01 | 2020-10-22 | |
| Polish Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) Registry Transcatheter Aortic Valve-in-Valve Implantation (ViV-TAVI) - Aortic Valve Stenosis, Aortic Valve Insufficiency | Unknown | Medical University of Warsaw | 150 | 2018-01-01 | 2020-10-22 | |
| A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction MYK-461 - Cardiomyopathy, Hypertrophic Obstructive, Left Ventricular Outflow Tract Obstruction | Phase 2 | Completed | MyoKardia, Inc. | 21 | 2016-08-01 | 2021-06-08 |
Cardiomyopathy, Hypertrophic (9) · Aortic Valve Stenosis (2) · Aortic Valve Insufficiency (1) · Cardiomyopathies (1) · Cardiovascular Diseases (1) · Coronary Artery Disease (1) · Heart Diseases (1) · Hypertrophy (1) · Ventricular Remodeling (1)
Aortic Valve Disease (11) · Heart Valve Diseases (11) · Ventricular Outflow Obstruction (11) · Cardiovascular Diseases (10) · Heart Diseases (10) · Aortic Stenosis, Subvalvular (9) · Aortic Valve Stenosis (9) · Cardiomyopathies (8) · Pathological Conditions, Anatomical (2) · Pathological Conditions, Signs and Symptoms (2) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Coronary Disease (1) · Myocardial Ischemia (1) · Vascular Diseases (1)
MYK-461 (4) · Echocardiography (1) · Electrocardiography (1) · Electrocardiography, Ambulatory (1) · Ethanol (1) · Metoprolol (1) · Transcatheter Aortic Valve Replacement (1) · Valsalva Maneuver (1)
Medical University of Warsaw (2) · Bristol-Myers Squibb (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · Mayo Clinic (1) · MyoKardia, Inc. (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · St. Antonius Hospital (1) · University Hospital, Bordeaux (1) · University Hospital, Motol (1) · University of Manchester (1)
United States (3) · Poland (2) · China (1) · Czechia (1) · France (1) · Netherlands (1) · United Kingdom (1)
Zenon Huczek, MD, PhD (2) · Amy Sehnert, MD (1) · Andrew Crean, BSc BM MRCP FRCR MPhil MPH (1) · Fatih Arslan, MD PhD (1) · Jeffrey Geske, MD (1) · Josef Veselka, MD, PhD (1) · Robert J Lederman, M.D. (1) · Wojciech Wojakowski, MD, PhD (1)
PMID 30009390, PMID 30603033, PMID 31035291, PMID 32808736, PMID 41303113