17 completed. 17 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 17 |
| Phase 2 | 7 | Completed 7 |
Follow Varicose Ulcer: new trials by email Literature Review of Varicose Ulcer trials Research Report on Varicose Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of XSTEM-VLU in Patients With Difficult-to-heal Venous Leg Ulcers XSTEM-VLU, Vehicle - Venous Leg Ulcer | Phase 1 / Phase 2 | Completed | Xintela AB | 6 | 2022-10-26 | 2026-06-26 |
| Treatment Outcome of Autologous PRP Versus Conventional Therapy Among Patients With Chronic Venous Leg Ulcers PRP, Conventional therapy - Venous Leg Ulcer | Phase 1 | Completed | Jinnah Postgraduate Medical Centre | 48 | 2022-09-01 | 2023-08-03 |
| Safety and Tolerability of Single and Multiple Doses of SoftOx Biofilm Eradicator (SBE) in Chronic Leg Wounds SoftOx Biofilm Eradicator (Groups 1 to 7), Sterile isotonic saline (Groups 1 to 4) - Chronic Leg Ulcer, Venous Leg Ulcer | Phase 1 | Completed | SoftOx Solutions AS | 28 | 2021-10-19 | 2023-02-02 |
| Allogeneic ABCB5-positive Stem Cells for Treatment of CVU allo-APZ2-CVU - Skin Ulcer Venous Stasis Chronic | Phase 1 / Phase 2 | Completed | RHEACELL GmbH & Co. KG | 31 | 2017-11-16 | 2020-09-10 |
| Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers Granexin - Venous Leg Ulcer | Phase 1 | Completed | Xequel Bio, Inc. | 10 | 2015-09-01 | 2018-08-01 |
| The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study NMBM, Compression garments - Ulcer, Venous Ulcer | Phase 1 / Phase 2 | Completed | M.D. Lederman Consulting Ltd | 30 | 2013-02-01 | 2017-01-11 |
| Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Cryotherapy: Cooling gel wrap, Usual care - Venous Disease, Venous Vascular Diseases and Syndromes | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 197 | 2011-08-01 | 2016-04-05 |
| Cell Therapy for Venous Leg Ulcers Pilot Study Autologous BMDC implantation at the venous ulcer - Venous Ulcer | Phase 1 | Completed | Hospital de Clínicas Dr. Manuel Quintela | 4 | 2011-05-01 | 2017-03-06 |
| Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers Revera Wound Care, Normal Saline - Venous Stasis Ulcers | Phase 1 | Completed | Revalesio Corporation | 13 | 2008-03-01 | 2012-06-26 |
| Assessment of the Safety and Efficacy of DERMASTREAM™ - ENZYSTREAM™ System for the Treatment of Chronic Venous Ulcers Papain - Lower Extremity Chronic Venous Ulcers | Phase 1 / Phase 2 | Completed | EnzySurge | 48 | 2007-07-01 | 2010-05-25 |
| Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers Celaderm (Frozen Cultured Epidermal Allograft), Control (compression bandaging) - Leg Ulcer, Varicose Ulcer | Phase 1 / Phase 2 | Completed | Shire | 40 | 2007-01-31 | 2021-06-11 |
| Wound Healing Effects of HO/03/03 In Patients With Diabetic Neuropathic Plantar and Venous Ulcers, Pilot Study. HO/03/03 - Diabetic Foot Ulcer, Venous Ulcer | Phase 1 | Completed | HealOr | 22 | 2006-06-01 | 2007-08-17 |
| FGF-1 for Topical Administration for the Treatment of Diabetic or Venous Stasis Ulcers FGF-1 - Chronic Wounds, Diabetes | Phase 1 | Completed | Venturis Therapeutics, Inc. | 8 | 2005-09-02 | 2026-08-19 |
| Preliminary Testing of New Treatment for Chronic Leg Wounds PDGF-B/Ad5 - Varicose Ulcer | Phase 1 | Completed | University of Pennsylvania | 24 | 2005-01-01 | 2013-05-13 |
| Preliminary Testing of New Treatment for Chronic Leg Wounds H5.020CMV.PDGF-b and limb compression bandage - Venous Ulcer | Phase 1 | Completed | University of Pennsylvania | 15 | 2004-09-01 | 2017-01-11 |
| Bioengineered Skin and Wound Healing Bioengineered skin - Leg Ulcers | Phase 1 | Completed | Roger Williams Medical Center | 50 | 2000-10-01 | 2013-08-02 |
| Treatment of Cutaneous Ulcers With a Novel Biological Dressing self assembled skin substitute (SASS) - Venous Ulcers | Phase 1 / Phase 2 | Completed | CHU de Quebec-Universite Laval | 6 | 1999-09-01 | 2014-02-11 |
Leg Ulcer (3) · Skin Ulcer (2) · Ulcer (2) · Bronchiolitis Obliterans Syndrome (1) · Diabetes Mellitus (1) · Diabetic Foot (1) · Syndrome (1) · Venous Insufficiency (1) · Wounds and Injuries (1)
Cardiovascular Diseases (17) · Skin Diseases (17) · Skin and Connective Tissue Diseases (17) · Varicose Veins (17) · Vascular Diseases (17) · Skin Ulcer (15) · Leg Ulcer (14) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Endocrine System Diseases (2) · Bronchial Diseases (1) · Bronchiolitis (1) · Bronchiolitis Obliterans (1) · Bronchitis (1) · Diabetes Complications (1)
Compression Bandages (1) · Fibroblast Growth Factor 1 (1) · Papain (1) · Standard of Care (1)
University of Pennsylvania (2) · CHU de Quebec-Universite Laval (1) · EnzySurge (1) · HealOr (1) · Hospital de Clínicas Dr. Manuel Quintela (1) · Jinnah Postgraduate Medical Centre (1) · M.D. Lederman Consulting Ltd (1) · Medical University of South Carolina (1) · RHEACELL GmbH & Co. KG (1) · Revalesio Corporation (1) · Roger Williams Medical Center (1) · Shire (1) · SoftOx Solutions AS (1) · Venturis Therapeutics, Inc. (1) · Xequel Bio, Inc. (1)
United States (7) · Israel (3) · Canada (1) · Denmark (1) · Germany (1) · Pakistan (1) · Sweden (1) · Uruguay (1)
Andreas Kerstan, Dr. (1) · Arie Bass, Prof. (1) · David J. Margolis, MD (1) · David J. Margolis, MD, PhD (1) · David Peick Sonne, MD; PhD (1) · Francois A Auger, MD (1) · Gabriela Otero, MD (1) · Glenn Gundersen, PhD (1) · Lucie Germain, Ph.D. (1) · Micha Rapoport, Dr. (1) · Rabia Ghafoor (1) · Sami Nitezki, Dr. (1)
PMID 25703058, PMID 26719678, PMID 26888961, PMID 29489633, PMID 33011075
N01AR092238 (1), R01AR046557 (1), R01NR012237 (1)