55 completed, 24 recruiting, 16 unknown, 8 terminated. 25 Not applicable, 24 Phase 2, 17 Phase 3, 14 Phase 4, 5 Phase 1.
Follow Uremia: new trials by email Literature Review of Uremia trials Research Report on Uremia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy NM8074 - aHUS - Atypical Hemolytic Uremic Syndrome | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-11-01 | 2026-04-13 |
| Ravulizumab Outcomes in Polish Patients With aHUS Ravulizumab - Atypical Hemolytic Uremic Syndrome | Recruiting | AstraZeneca | 80 | 2026-06-24 | 2026-09-15 | |
| Anrikefon vs Nalfurafine for Sleep Quality in Hemodialysis Patients With CKD-aP Anrikefon, Nalfurafine - Pruritus Chronic, Kidney Diseases, Chronic | Phase 4 | Recruiting | Zhujiang Hospital | 50 | 2026-06-22 | 2026-08-25 |
| Expanded Hemodialysis Versus High-Volume Online Hemodiafiltration for Uremic Toxin Removal Expanded Hemodialysis With Medium Cut-Off Membrane, High-Volume Online Hemodiafiltration - End Stage Renal Disease (ESRD), Chronic Kidney Disease on Hemodialysis | Not applicable | Not yet recruiting | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | 15 | 2026-04-01 | 2026-03-24 |
| ICHARUS: Italian Cooperative HemoAdsorption Study for Relief of Uremic Symptoms Chronic Kidney Disease 5D, Uremia; Chronic | Recruiting | Azienda Ospedaliera Brotzu | 120 | 2026-03-15 | 2026-04-21 | |
| Post-Marketing Clinical Study of Ravulizumab in Participants With Clinical aHUS Ravulizumab - aHUS, Atypical Hemolytic Uremic Syndrome | Phase 4 | Recruiting | Alexion Pharmaceuticals, Inc. | 20 | 2025-12-19 | 2026-04-20 |
| Timing of Renal Replacement Therapy in the Critically Ill Patients CRRT - Acute Kidney Injury, Uremia | Recruiting | Karolinska University Hospital | 50000 | 2025-11-01 | 2025-09-03 | |
| The Burden of Atypical Hemolytic Uremic Syndrome and The Clinical Characteristics of Patients in Egyptian Hospitals A Multicenter, Observational, Retrospective Cohort Study in Egypt Atypical Hemolytic Uremic Syndrome | Completed | AstraZeneca | 200 | 2025-10-13 | 2026-08-18 | |
| Non-invasive Testing for End-Stage Chronic Kidney Disease KF4+ Noninvasive Test - Renal Disease, Chronic, Renal Disease, End-Stage | Completed | Gisens Biotech | 55 | 2025-10-01 | 2026-08-20 | |
| Dynamic Breath VOC Profiling as a Non-invasive Tool to Assess Hemodialysis Adequacy hemodialysis - Uremia, Uremia; Chronic | Not yet recruiting | Second People's Hospital, Shanghai | 50 | 2025-09-30 | 2025-09-24 | |
| A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole Dipyridamole 50mg tid - Restless Leg Syndrome Due to Uraemia | Phase 2 / Phase 3 | Recruiting | Yunfeng Xia | 80 | 2025-09-20 | 2026-04-22 |
| Studies on Adsorption International Learning Initiative Global Patients will undergo a combined hemodialysis and hemosorption procedure. The study cartridge for hemosorption by Jafron HA130 contains the original adsorbing material. - CKD (Chronic Kidney Disease) Stage 5D, Uremia; Chronic | Not applicable | Recruiting | Botkin Hospital | 60 | 2025-06-01 | 2025-12-10 |
| BCD to Measure the ED95 of Remimazolam-Assisted Sedation in Arteriovenous Fistula Creation Surgery remimazolam sedation - Uremia | Phase 4 | Not yet recruiting | Gang Chen | 40 | 2025-06-01 | 2025-05-31 |
| Predictive Value of Carotid Ultrasonography for Intradialytic Hypotension Non-invasive Monitoring - Intradialytic Hypotension, End-Stage Renal Disease Requiring Haemodialysis | Recruiting | First Affiliated Hospital of Wannan Medical College | 183 | 2025-02-01 | 2025-06-24 | |
| Multi-center Clinical Study on Hemoperfusion of KHA80 KHA80 hemoperfusion treatment - Uremia, Uremic Osteodystrophy | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 394 | 2025-01-13 | 2025-01-14 |
| Pancreas Transplant Alone in Uremia and Non-uremia Patients pancreas transplant - Pancreas Transplant, Type 1 Diabetes Mellitus | Completed | Taipei Veterans General Hospital, Taiwan | 184 | 2025-01-01 | 2026-10-14 | |
| Study of Ultomiris® (Ravulizumab) Safety in Pregnancy Ultomiris - Ultomiris-exposed Pregnant/ Postpartum, Pregnancy | Recruiting | Alexion Pharmaceuticals, Inc. | 75 | 2024-12-16 | 2026-04-16 | |
| Efficacy of INM004 in Children With STEC-HUS INM004, Placebo - Hemolytic-Uremic Syndrome | Phase 3 | Recruiting | Inmunova S.A. | 220 | 2024-10-05 | 2026-01-15 |
| Evaluate Long-term Safety, Tolerability and Efficacy of Iptacopan in Study Participants With aHUS Iptcaopan 200 mg - Atypical Hemolytic Uremic Syndrome | Phase 3 | Recruiting | Novartis Pharmaceuticals | 65 | 2024-05-08 | 2026-06-04 |
| Evaluation of the Efficacy of Laser Acupuncture on Uremic Pruritus laser acupuncture - Uremia | Not applicable | Completed | Dalin Tzu Chi General Hospital | 60 | 2024-04-09 | 2025-12-24 |
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Atypical Hemolytic Uremic Syndrome (45) · Hemolytic-Uremic Syndrome (26) · Thrombotic Microangiopathies (16) · Kidney Failure, Chronic (11) · Renal Insufficiency, Chronic (11) · Bronchiolitis Obliterans Syndrome (8) · Acute Kidney Injury (6) · Purpura, Thrombotic Thrombocytopenic (6) · Glomerulonephritis, Membranoproliferative (4) · Kidney Diseases (4) · Pruritus (4) · Anemia (3) · Cardiovascular Diseases (3) · Escherichia coli Infections (3)
Female Urogenital Diseases (120) · Female Urogenital Diseases and Pregnancy Complications (120) · Male Urogenital Diseases (120) · Urogenital Diseases (119) · Urologic Diseases (119) · Kidney Diseases (116) · Hemic and Lymphatic Diseases (69) · Cytopenia (68) · Hematologic Diseases (68) · Blood Platelet Disorders (67) · Anemia (66) · Anemia, Hemolytic (66) · Thrombocytopenia (65) · Thrombotic Microangiopathies (52)
eculizumab (13) · ravulizumab (5) · Renal Dialysis (3) · narsoplimab (3) · Blood Specimen Collection (2) · Dialysis (2) · Exercise (2) · Gabapentin (2) · Glucose (2) · avacopan (2) · iptacopan (2) · Amino Acids (1) · Ascorbic Acid (1) · Basiliximab (1) · Bortezomib (1)
Alexion Pharmaceuticals, Inc. (16) · Mario Negri Institute for Pharmacological Research (6) · AstraZeneca (4) · Inmunova S.A. (3) · Novartis Pharmaceuticals (3) · Bo Feldt-Rasmussen (2) · Fundación Grupo de Investigación en Cuidados Intensivos y Obstetricia (2) · Fuzhou General Hospital (2) · Hoffmann-La Roche (2) · Hospices Civils de Lyon (2) · Miulli General Hospital (2) · Omeros Corporation (2) · Region Skane (2) · University Hospital, Tours (2) · University of Calgary (2)
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Anders Christensson, MD, PhD (2) · Marina Noris, PhD (2) · Alejandro Balestracci, MD, PhD (1) · Altair J Mocelin, MD PHD (1) · Amy Schmidt, MD PhD (1) · Archna Hale (1) · Arnaud Garnier, MD (1) · Bo Feldt-Rasmussen, Prof, DMSc (1) · Carlo Basile, MD (1) · Changlin Mei, MD (1) · Chiu-Ching Huang, MD (1)
PMID 33783815, PMID 40277027, PMID 23738544, PMID 34219224, PMID 10946805, PMID 11453873, PMID 12966125, PMID 17472838, PMID 20813866, PMID 21388319, PMID 21877169, PMID 22240130, PMID 23136214, PMID 23624993, PMID 24228847, PMID 24360866, PMID 24557989, PMID 24712563, PMID 24843058, PMID 25833956, PMID 25896788, PMID 26283739, PMID 26654630, PMID 26701835, PMID 26780484, PMID 27871301, PMID 28151412, PMID 29424935, PMID 30723975, PMID 30971227, PMID 31299919, PMID 31672793, PMID 32299680, PMID 32739210, PMID 33048203, PMID 33270832, PMID 33283264, PMID 33407224, PMID 33533547, PMID 33693990, PMID 33774745, PMID 34169200, PMID 34852172, PMID 35123930, PMID 35166922, PMID 35439028, PMID 36152218, PMID 36329366, PMID 37245030, PMID 37303085
2014 (3), 2016 (2), 2023 (2), 2015 (1), 2018 (1), R01AI165327 (1), R01DK052147 (1)