252 completed, 129 unknown, 111 recruiting, 44 not yet recruiting. 204 Phase 2, 156 Phase 3, 66 Phase 1, 45 Not applicable, 32 Phase 4.
Follow Thrombotic Microangiopathies: new trials by email Literature Review of Thrombotic Microangiopathies trials Research Report on Thrombotic Microangiopathies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of NM8074 in Patients With aHUS With Evidence of Ongoing Thrombotic Microangiopathy NM8074 - aHUS - Atypical Hemolytic Uremic Syndrome | Phase 2 | Not yet recruiting | NovelMed Therapeutics | 12 | 2027-11-01 | 2026-04-13 |
| A Study of Ianalumab in Addition to Eltrombopag in Pediatric Patients With Primary ITP Who Failed Corticosteroids. Ianalumab, Eltrombopag - Primary Immune Thrombocytopenia (ITP) | Phase 2 | Not yet recruiting | Novartis Pharmaceuticals | 36 | 2027-02-08 | 2026-06-25 |
| Phase 1 Dose Escalation Study of RXIM002 in Autoimmune Cytopenias RXIM002 - Immune Thrombocytopenia (ITP) | Phase 1 | Not yet recruiting | RiboX Therapeutics Ltd. | 27 | 2027-02-01 | 2026-09-23 |
| A Phase 1b/2a Study of Velinotamig in Adults With Relapsed/Refractory ITP and wAIHA Velinotamig specified dose on specified days. - Immune Thrombocytopenia (ITP), Warm Autoimmune Hemolytic Anemia (WAIHA) | Phase 1 / Phase 2 | Not yet recruiting | Cullinan Therapeutics Inc. | 72 | 2026-12-01 | 2026-07-31 |
| TGD001 Treatment in Thrombotic Microangiopathies TGD001 - Thrombotic Microangiopathies, ITP Immune-Mediated Thrombocytopenia | Phase 1 / Phase 2 | Not yet recruiting | TargED Biopharmaceuticals B.V. | 70 | 2026-10-31 | 2026-09-29 |
| A Study to Learn More About the Treatment of People With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Who Received Recombinant ADAMTS13 (rADAMTS13) as Part of the Early Access Program No Intervention - Thrombotic Thrombocytopenic Purpura (TTP) | Recruiting | Takeda | 94 | 2026-09-24 | 2026-10-20 | |
| Selective Mediterranean Diet in Immune Thrombocytopenia Selective Mediterranean Diet, Standard Pharmacological Therapy for ITP - Immune Thrombocytopenia, Idiopathic Thrombocytopenic Purpura | Not applicable | Not yet recruiting | Assiut University | 60 | 2026-09-01 | 2026-09-03 |
| Clinical Study of CHT105 Injection in the Treatment of Relapsed/Refractory Autoimmune Diseases CHT105 - Immune Thrombocytopenia (ITP) | Not applicable | Not yet recruiting | Nanjing Miracle Biotechnology Co., Ltd. | 24 | 2026-09-01 | 2026-09-10 |
| The Role of interferOn and Complement in SecondAry thRombotic micrioangiOpathy blood draw, urine collection - Thrombotic Microangiopathies | Not applicable | Not yet recruiting | Sofie Dhaese | 40 | 2026-09-01 | 2026-07-15 |
| Safety and Efficacy of Iptacopan in Patients With High-Risk Transplantation-Associated Thrombotic Microangiopathy iptacopan - Thrombotic Microangiopathy, Hematopoietic Stem Cell Transplantation (HSCT) | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 30 | 2026-08-25 | 2026-08-26 |
| A Study of Romiplostim Plus Predniso(lo)ne vs. Predniso(lo)ne Alone for the Treatment of Previously Untreated Primary Immune Thrombocytopenia (ITP) Romiplostim, Predniso(lo)ne - Primary Immune Thrombocytopenia | Phase 3 | Recruiting | Amgen | 126 | 2026-08-21 | 2026-09-17 |
| A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP) ianalumab, thrombopoietin receptor agonist (TPO-RA) - Primary Immune Thrombocytopenia (ITP), Primary Evans Syndrome (ES) | Phase 2 | Recruiting | Novartis Pharmaceuticals | 164 | 2026-08-04 | 2026-10-22 |
| Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease CTX112 - Warm Autoimmune Hemolytic Anemia (WAIHA), ITP - Immune Thrombocytopenia | Phase 1 / Phase 2 | Recruiting | CRISPR Therapeutics AG | 60 | 2026-07-17 | 2026-10-20 |
| Bioequivalence Study of SKI-O-703 in Healthy Adults Under Fed Conditions SKI-O-703 API in Capsules, SKI-O-703 Formulated Granules in Capsules - Bioequivalence Study in Healthy Subjects, Immune Thrombocytopenia (ITP) | Phase 1 | Active not recruiting | Oscotec Inc. | 48 | 2026-07-10 | 2026-09-01 |
| Eltrombopag Plus Telitacicept vs. Eltrombopag Alone for Steroid-refractory/Relapsed ITP Eltrombopag - Immune Thrombocytopenia | Phase 2 | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 40 | 2026-07-10 | 2026-07-07 |
| TPO-RA Plus Baricitinib vs. TPO-RA for ITP Baricitinib, TPO-RA - ITP - Immune Thrombocytopenia | Phase 2 | Not yet recruiting | Peking University People's Hospital | 100 | 2026-07-01 | 2026-06-25 |
| Modeling the Early Stages of Autoimmunity Through the Study of Immunological Thrombocytopenic Purpura and Juvenile Lupus Blood sampling baseline and M3, Monitoring for SLE, Procedure/Surgery: Blood sampling baseline and M3 then each 6 months until 48 months - Immune Thrombocytopenic Purpura ( ITP ), Systemic Lupus Erythematosus (SLE) | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 105 | 2026-07-01 | 2026-07-17 |
| Study of Ianalumab in Adults With Primary Immune Thrombocytopenia (ITP) and Warm-antibody Autoimmune Hemolytic Anemia (wAIHA) Who Have Previously Benefited From Ianalumab Ianalumab - Primary Immune Thrombocytopenia, Warm Autoimmune Hemolytic Anemia | Phase 2 | Withdrawn | Novartis Pharmaceuticals | 2026-06-26 | 2026-10-15 | |
| A Real-world Study of Treatment Patterns and Outcomes in Primary Immune Thrombocytopenia Patients Treated With Eltrombopag Immune Thrombocytopenia | Recruiting | Novartis Pharmaceuticals | 150 | 2026-06-25 | 2026-10-15 | |
| Ravulizumab Outcomes in Polish Patients With aHUS Ravulizumab - Atypical Hemolytic Uremic Syndrome | Recruiting | AstraZeneca | 80 | 2026-06-24 | 2026-09-15 |
Showing 20 of 637. Sign in to see all of them.
Purpura, Thrombocytopenic, Idiopathic (481) · Purpura, Thrombotic Thrombocytopenic (65) · Thrombocytopenia (57) · Atypical Hemolytic Uremic Syndrome (45) · Purpura, Thrombocytopenic (30) · Hemolytic-Uremic Syndrome (26) · Purpura (20) · Lupus Erythematosus, Systemic (19) · Anemia, Hemolytic, Autoimmune (18) · Hematologic Diseases (18) · Autoimmune Diseases (17) · Blood Platelet Disorders (12) · Hemorrhage (12) · Arthritis, Rheumatoid (8)
Hemic and Lymphatic Diseases (637) · Cytopenia (633) · Blood Platelet Disorders (625) · Hematologic Diseases (619) · Thrombocytopenia (580) · Pathological Conditions, Signs and Symptoms (559) · Pathologic Processes (557) · Signs and Symptoms (550) · Blood Coagulation Disorders (545) · Skin Manifestations (545) · Hemorrhage (537) · Purpura (529) · Purpura, Thrombocytopenic (519) · Immune System Diseases (497)
eltrombopag (54) · Dexamethasone (46) · Rituximab (46) · romiplostim (34) · Immunoglobulins, Intravenous (18) · avatrombopag (18) · Prednisone (15) · eculizumab (14) · Danazol (12) · Blood Specimen Collection (11) · Thrombopoietin (11) · fostamatinib (11) · ravulizumab (9) · Inosine Triphosphate (8) · Tretinoin (8)
Peking University People's Hospital (49) · Shandong University (38) · Institute of Hematology & Blood Diseases Hospital, China (34) · Alexion Pharmaceuticals, Inc. (21) · Novartis Pharmaceuticals (20) · Amgen (19) · Assistance Publique - Hôpitaux de Paris (16) · Assiut University (14) · University Hospital, Bordeaux (13) · GlaxoSmithKline (12) · Sohag University (10) · Takeda (10) · Weill Medical College of Cornell University (10) · Eisai Inc. (8) · Gruppo Italiano Malattie EMatologiche dell'Adulto (8)
China (194) · United States (168) · France (105) · United Kingdom (86) · Italy (82) · Germany (73) · Spain (73) · Poland (48) · Canada (44) · Japan (42) · Australia (39) · Austria (34) · Netherlands (34) · South Korea (34) · Czechia (31)
Lei Zhang, MD (14) · Xiao-Hui Zhang, MD (14) · Xiaohui Zhang, MD (8) · Ming Hou, Dr (6) · Ming Hou (5) · Ming Hou, Dr. (5) · James B Bussel, M.D. (4) · David Gomez-Almaguer, MD (3) · James Bussel, MD (3)
PMID 33783815, PMID 19005182, PMID 40277027, PMID 19671919, PMID 23738544, PMID 24802773, PMID 34219224, PMID 19846889, PMID 26231455, PMID 26688484, PMID 33995988, PMID 12944568, PMID 17077333, PMID 18242413, PMID 20546023, PMID 21533818, PMID 22117897, PMID 22409309, PMID 22494019, PMID 23293082, PMID 23470153, PMID 23492914, PMID 24254965, PMID 24802775, PMID 26480931, PMID 27734464, PMID 29042367, PMID 29536526, PMID 33881463, PMID 34452956, PMID 39874521, PMID 11919310, PMID 12353309, PMID 12359731, PMID 12611000, PMID 12966125, PMID 15389904, PMID 15661401, PMID 17164349, PMID 17452226, PMID 17849048, PMID 18046028, PMID 18463354, PMID 18510702, PMID 18574602, PMID 18782260, PMID 19096013, PMID 19208097, PMID 19231632, PMID 19446149
2023 (9), 2019 (7), 2018 (6), 2014 (5), 2016 (4), 2017 (3), 2025 (3), 2009 (2), 2015 (2), U01HL072268 (2), 2004 (1), P30CA015083 (1), R01AI165327 (1), R01DK052147 (1), R01HL031768 (1)