12 completed. 12 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 12 |
| Phase 2 | 3 | Completed 3 |
Follow Typhoid Fever: new trials by email Literature Review of Typhoid Fever trials Research Report on Typhoid Fever
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity of a Novel Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults TYP04A Low Dose without Alum investigational vaccine, TYP04B Full Dose without Alum investigational vaccine, TYP03A Low Dose with Alum investigational vaccine - Typhoid Fever | Phase 1 | Completed | GlaxoSmithKline | 97 | 2022-11-28 | 2025-01-24 |
| Non-inferiority Trial of Locally Manufactured Typhoid Conjugate Vaccine 'Typhocon' in Bangladesh Typhoid Vi polysaccharide-diphtheria toxoid conjugate vaccine (Vi-DT) - Typhoid | Phase 1 / Phase 2 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 630 | 2022-07-01 | 2024-12-24 |
| Study to Evaluate the Safety, Tolerability and Immunogenicity of a Potential Enteric Fever Vaccine ZH9PA and ZH9, Placebo, ZH9PA - Enteric Fever | Phase 1 | Completed | Prokarium Ltd | 46 | 2019-12-16 | 2025-08-17 |
| Safety and Tolerability of Typhoid Conjugate Vaccine (EuTCV) in Healthy Adults EuTCV, Typbar-TCV™, Typhim Vi® - Typhoid Fever | Phase 1 | Completed | EuBiologics Co.,Ltd | 75 | 2019-03-16 | 2019-12-09 |
| Effects of Aging on Primary and Secondary Vaccine Responses Fluzone® quadrivalent, Fluzone High Dose, Fluad - Influenza, Hepatitis A | Phase 1 | Completed | Stanford University | 54 | 2017-09-19 | 2024-12-16 |
| Safety and Immunogenicity of a Vi-DT Typhoid Conjugate Vaccine Vi-DT, Typhim Vi®, VAXIGRIP® - Typhoid | Phase 1 | Completed | International Vaccine Institute | 144 | 2016-05-19 | 2020-04-28 |
| Safety and Immunogenicity of Typhax, a Typhoid Vaccine Typhax (investigational typhoid fever candidate vaccine), Placebo, Active Comparator Typhim Vi - Typhoid Fever | Phase 1 | Completed | Matrivax Research and Development Corporation | 45 | 2016-03-28 | 2019-04-24 |
| Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old) Typherix, NVGH Vi-CRM197 - Typhoid Fever | Phase 1 | Completed | Novartis | 50 | 2010-05-01 | 2014-01-17 |
| Studies of Immune Responses to Orally Administered Vaccines in Developing Country Placebo, Control, Zinc Sulphate - Cholera, Typhoid | Phase 1 / Phase 2 | Completed | International Centre for Diarrhoeal Disease Research, Bangladesh | 1016 | 2008-02-01 | 2011-07-12 |
| TY800 Dose Escalation (Typhoid) Ty800, Placebo - Typhoid and Paratyphoid Fevers | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 47 | 2006-02-01 | 2011-06-10 |
| CVD 909 Vi Prime Boost Study CVD 909, Placebo, Vi Polysaccharide - Typhoid Fever | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 21 | 2006-02-01 | 2014-05-09 |
| Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine BB IND 6989 - Typhoid Fever | Phase 1 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 25 | 2006-01-09 | 2017-07-02 |
Paratyphoid Fever (2) · Cholera (1) · Hepatitis A (1) · Influenza, Human (1)
Bacterial Infections (12) · Bacterial Infections and Mycoses (12) · Enterobacteriaceae Infections (12) · Gram-Negative Bacterial Infections (12) · Infections (12) · Salmonella Infections (12) · Digestive System Diseases (1) · Enterovirus Infections (1) · Hepatitis (1) · Hepatitis, Viral, Human (1) · Liver Diseases (1) · Orthomyxoviridae Infections (1) · Picornaviridae Infections (1) · RNA Virus Infections (1) · Respiratory Tract Diseases (1)
Vi polysaccharide vaccine, typhoid (4) · Adjuvants, Vaccine (1) · Albendazole (1) · Arsenic (1) · Boostrix (1) · Fluzone High-Dose (1) · Hepatitis A Vaccines (1) · Polysaccharides (1) · Ty21a typhoid vaccine (1) · Vaccines (1) · Zinc Sulfate (1) · fluad vaccine (1) · secnidazole (1) · vaxigrip (1)
International Centre for Diarrhoeal Disease Research, Bangladesh (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · EuBiologics Co.,Ltd (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · GlaxoSmithKline (1) · International Vaccine Institute (1) · Matrivax Research and Development Corporation (1) · Novartis (1) · Prokarium Ltd (1) · Stanford University (1)
United States (4) · Bangladesh (2) · Belgium (2) · Philippines (1) · United Kingdom (1)
Cornelia Dekker, MD (1) · Farhana Khanam, MPhil, PhD (1) · Firdausi Qadri, PhD (1) · Maria Rosario Capeding, MD (1) · Pierre VanDamme, Dr. (1) · Scott Boyd, MD, PhD (1)
PMID 21980445, PMID 24657719, PMID 29776750, PMID 31905228, PMID 33807097, PMID 33849723, PMID 41587557, PMID 42234814
R01AI130398 (1)