12 completed, 3 active not recruiting, 3 recruiting, 2 unknown. 8 Phase 2, 7 Phase 4, 3 Phase 1, 2 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Immunogenicity of Standard-Dose Versus High-Dose Influenza Vaccines in Older Adults in Singapore High-dose influenza vaccine, Standard-dose influenza vaccine - Influenza | Phase 4 | Not yet recruiting | Tan Tock Seng Hospital | 150 | 2026-11-01 | 2026-10-20 |
| High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater) Fluzone High Dose Inactivated Influenza Vaccine, Fluzone Standard Dose Inactivated Influenza Vaccine - Immunization; Infection|Transplantation Infection|Influenza, Influenza | Phase 2 | Recruiting | Vanderbilt University Medical Center | 60 | 2025-09-17 | 2026-10-21 |
| A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine CIC Vaccine Co-formulated tNIV2 , SARSCoV-2 rS and Matrix-M Adjuvant, Novavax COVID-19 Vaccine, tNIV Vaccine - COVID-19 | Phase 3 | Completed | Novavax | 9320 | 2024-12-09 | 2026-06-05 |
| High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients Standard Dose Quadrivalent Inactivated Influenza Vaccine, High Dose Quadrivalent Inactivated Influenza Vaccine - Immunization; Infection, Transplantation Infection | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 312 | 2024-09-26 | 2026-10-28 |
| Fluad vs. Fluzone High-Dose Vaccine Effectiveness Among Adults ≥65 Years Adjuvanted Quadrivalent Inactivated Influenza Vaccine (aIIV4), High-Dose Quadrivalent Inactivated Influenza Vaccine (HD-IIV4) - Influenza, Community-acquired Pneumonia | Recruiting | Kaiser Permanente | 1500000 | 2023-08-17 | 2026-08-05 | |
| High vs. Standard Dose Influenza Vaccine in Lung Allograft Recipients High Dose Quadrivalent Inactivated Influenza Vaccine, Standard Dose Quadrivalent Inactivated Influenza Vaccine - Immunization; Infection, Transplantation Infection | Phase 2 | Active not recruiting | Vanderbilt University Medical Center | 270 | 2022-11-08 | 2026-09-04 |
| B Cell and Antibody Response to Seasonal Influenza Vaccines in Younger and Older Adults Fluzone, Flucelvax, Fluzone High-Dose - Influenza | Phase 4 | Active not recruiting | University of Alabama at Birmingham | 50 | 2021-04-01 | 2026-05-14 |
| High vs. Standard Dose Influenza Vaccine in Adult SOT Recipients High Dose Quadrivalent Inactivated Influenza Vaccine, Standard Dose Quadrivalent Inactivated Influenza Vaccine - Immunization; Infection, Transplantation Infection | Phase 2 | Active not recruiting | Vanderbilt University Medical Center | 396 | 2021-01-11 | 2026-10-02 |
| Intradermal Influenza Vaccine With Topical Imiquimod in Elderly and Chronic Illness Patients Vaxigrip tetra, Fluzone high-dose, Aldara 5% Topical Cream - Influenza | Phase 3 | Unknown | The University of Hong Kong | 4000 | 2019-10-23 | 2021-04-28 |
| Influenza Vaccination for Flu Prevention in Patients With Plasma Cell Disorders Pneumococcal 13-valent Conjugate Vaccine, Trivalent Influenza Vaccine - Plasma Cell Neoplasm | Phase 4 | Completed | Emory University | 165 | 2019-10-18 | 2025-02-28 |
| Systems Analyses of the Immune Response to the Seasonal Influenza Vaccine Flucelvax, Fluvirin, Fluzone High Dose - Healthy Volunteer | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 98 | 2019-10-02 | 2024-01-02 |
| Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP Flublok, Flucelvax, Fluarix - Influenza | Phase 4 | Completed | Centers for Disease Control and Prevention | 944 | 2018-09-12 | 2024-07-22 |
| Gene Signatures of Influenza Vaccine Responses in Older Adults Fluad Vaccine, Fluzone High-Dose - Influenza | Phase 4 | Completed | Mayo Clinic | 241 | 2018-08-27 | 2023-05-16 |
| Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers Trivalent Influenza Vaccine - Acute Myeloid Leukemia, Myelodysplastic Syndrome | Early Phase 1 | Completed | Roswell Park Cancer Institute | 130 | 2017-10-17 | 2023-06-06 |
| Effects of Aging on Primary and Secondary Vaccine Responses Fluzone® quadrivalent, Fluzone High Dose, Fluad - Influenza, Hepatitis A | Phase 1 | Completed | Stanford University | 54 | 2017-09-19 | 2024-12-16 |
| Study of High-dose Influenza Vaccine Efficacy by Repeated Dosing In Gammopathy Patients Fluzone - Influenza, Gammopathy | Phase 1 | Completed | Yale University | 51 | 2014-10-01 | 2016-08-25 |
| A Pilot Study to Assess the Immunogenicity and Reactogenicity of High Versus Standard Dose TIV Fluzone High-Dose, Fluzone (standard dose) - Influenza | Phase 1 / Phase 2 | Completed | Mount Sinai Hospital, Canada | 170 | 2014-10-01 | 2019-01-28 |
| Duration of Immune Response to Influenza Vaccination in Patients With RA Influenza vaccine - Rheumatoid Arthritis | Phase 4 | Completed | Bassett Healthcare | 87 | 2014-08-01 | 2017-01-06 |
| High-Dose Influenza Vaccine in Nursing Homes HD Vaccine, SD Vaccine, Free Vaccine - Influenza | Phase 4 | Unknown | Insight Therapeutics, LLC | 823 | 2013-02-01 | 2018-07-16 |
| Immunogenicity of Fluzone High Dose in Immunocompromised Children and Young Adults Fluzone High Dose, Fluzone - Solid Organ Transplant Recipient (Liver, Kidney, Heart), Rheumatologic Disorder | Phase 2 | Completed | University of Colorado, Denver | 16 | 2012-09-01 | 2018-01-23 |
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Influenza, Human (16) · Communicable Diseases (3) · Infections (3) · COVID-19 (2) · Acquired Immunodeficiency Syndrome (1) · Arthritis, Rheumatoid (1) · Collagen Diseases (1) · Community-Acquired Pneumonia (1) · Hepatitis A (1) · Leukemia, Myeloid, Acute (1) · Myelodysplastic Syndromes (1) · Neoplasms (1) · Neoplasms, Plasma Cell (1) · Typhoid Fever (1)
Vanderbilt University Medical Center (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Bassett Healthcare (1) · Centers for Disease Control and Prevention (1) · Emory University (1) · Insight Therapeutics, LLC (1) · Kaiser Permanente (1) · Mayo Clinic (1) · Mount Sinai Hospital, Canada (1) · Novavax (1) · Roswell Park Cancer Institute (1) · Saad Jamshed MD (1) · Stanford University (1) · Tan Tock Seng Hospital (1) · The University of Hong Kong (1)
United States (17) · Australia (1) · Canada (1) · Hong Kong (1) · New Zealand (1) · Singapore (1)
Allison J McGeer, MD (1) · Andrew Branagan, MD (1) · Barnaby E Young, MB BChir, PhD (1) · Brendan Flannery, PhD (1) · Cornelia Dekker, MD (1) · Craig Hofmeister, MD, MPH (1) · Donald Raddatz, MD (1) · Donna Curtis, MD, MPH (1) · Ed Davidson, PharmD, MPH (1) · Elizabeth A Griffiths (1) · Fatimah Dawood, MD (1) · Ivan FN Hung, MD FRCP (1) · James J Kobie, PhD (1) · Natahsa Halasa, MD, MPH (1)
PMID 26721330, PMID 26908539, PMID 28736045, PMID 34245243, PMID 36031405, PMID 36599369, PMID 38177116, PMID 42081247
P30CA138292 (1), R01AI130398 (1), R01AI132348 (1)