Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching

NCT07770373 — Not applicable, Not yet recruiting, 38 participants, Cairo University

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Effect of Prophylaxis Pastes With and Without Desensitizing Agents Prior to In-office Bleaching on Color Change and Tooth Sensitivity: Randomized Clinical Trial

Registry	NCT07770373
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: triple, treatment
Enrollment	38 (Estimated)
Sponsor	Cairo University (Other)
Conditions	Discolored Teeth
Interventions	Treatment (Other)
Dates	start 2026-08-01 (estimated), primary completion 2026-08-01 (estimated), completion 2026-08-01 (estimated), first posted 2026-08-18, last updated 2026-08-18

-Summary

To evaluate the effect of prophylaxis pastes with and without desensitizing agents prior to in-office bleaching on color change and tooth sensitivity.

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+Arms and interventions

Arm	Type	Interventions	Description
Prophylaxis paste with desensitizing agent	Experimental	Other: Treatment	Prophylaxis paste with desensitizing agent
Prophylaxis paste without desensitizing agent	Placebo comparator	Other: Treatment	Prophylaxis paste without desensitizing agent

Treatment (Other): Prophylaxis paste will be applied to all tooth surfaces using a prophy cup attached to a low-speed contra-angle handpiece. The paste will remain on the teeth for the duration specified in the manufacturer's instructions for use before being rinsed away.

+Outcome measures

Primary outcomes

Color change [Baseline, Immediate after bleaching]: Tooth color will be measured using the VITA Easyshade V spectrophotometer. Color measurements will be recorded in the CIE L*, a*, and b* color space, and the color difference will be calculated using the CIEDE2000 color-difference formula (ΔE00).

Secondary outcomes

Tooth sensitivity [Baseline, Immediate after bleaching]: Pain intensity will be assessed using a 10-cm Visual Analog Scale (VAS), ranging from 0 (no pain) to 10 (worst pain imaginable). Patients will be asked to place a mark on the 10-cm VAS corresponding to the intensity of their pain.

+Eligibility

Sex: All, ages: 18 Years to 45 Years

Inclusion Criteria:

* Patients who have discolored teeth, minimum of 20 natural teeth, good oral hygiene, do not have any systemic disease.

Exclusion Criteria:

* Patients who have extensive prosthesis or restoration, tetracycline discoloration or fluorosis, endodontically treated teeth or gingival recession, smokers, periodontal disease, pregnant or lactating.

+Investigators

Zeinab O Tolba, Associate Professor, Principal investigator, Cairo University