14 completed, 3 unknown, 2 not yet recruiting, 1 withdrawn. 16 Not applicable, 2 Phase 4, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 16 | Completed 13, Not yet recruiting 2, Withdrawn 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Tooth Bleaching: new trials by email Literature Review of Tooth Bleaching trials Research Report on Tooth Bleaching
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of an Experimental Gel Based on Libidibia Ferrea on Post-bleaching Tooth Sensitivity Placebo, KF2 - Potassium nitrate, Jucá - Libidibia ferrea gel - Tooth Bleaching, Pain | Not applicable | Not yet recruiting | Universidade Federal do Para | 75 | 2026-06-13 | 2026-05-22 |
| Effects of an Experimental Propolis Gel on Tooth Sensitivity Control and Post-bleaching Color Change: a Randomized Clinical Trial Placebo - gel KY original, Propolis gel, KF2- Potassium nitrate - Tooth Bleaching, Pain | Not applicable | Not yet recruiting | Universidade Federal do Para | 66 | 2026-04-29 | 2026-05-06 |
| Effect of Andiroba on Control of Post-whitening Tooth Sensitivity AG (experimental Andiroba Gel), KF2G (Potassium nitrate gel), PG (Placebo Gel) - Tooth Bleaching, Pain | Not applicable | Completed | Universidade Federal do Para | 75 | 2024-10-01 | 2025-03-30 |
| Photobiomodulation Before or After Tooth Whitening Photobiomodulation with low power laser - Tooth Sensitivity, Tooth Bleaching | Not applicable | Completed | Universidade Federal do Para | 64 | 2024-07-15 | 2024-10-23 |
| Pregabalin Gel in Reducing Post-operative Tooth Sensitivity Surgery Caused by Bleaching With 35% Hydrogen Peroxide pregabalin gel, gel with 5% potassium nitrate and 2% sodium fluoride, Placebo gel - Tooth Bleaching, Sensitivity, Tooth | Phase 3 | Unknown | Universidade Federal do Para | 75 | 2024-01-05 | 2023-12-22 |
| The Effect of an Experimental Gel Based on Acmella Oleracea Extract in Reducing Post-bleaching Tooth Sensitivity EG (Experimental A. Oleracea extract gel), GP (Gel placebo) - Tooth Bleaching, Pain | Not applicable | Completed | Universidade Federal do Para | 50 | 2022-11-07 | 2023-02-13 |
| Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain the Oclean Digital Visual toothbrush (2.16 N·cm torque), Oral B manual toothbrush, the Oclean Sonic Electric toothbrush (1.96 N·cm torque) - Tooth Bleaching | Not applicable | Completed | Sun Yat-sen University | 129 | 2022-03-05 | 2025-12-22 |
| The Effectiveness of At-home , In-office and Combined Dental Bleaching System ：A Randomized Controlled Clinical Trial different combined of tooth bleaching procedure - Tooth Bleaching | Not applicable | Completed | Fujian Medical University | 48 | 2021-07-15 | 2023-09-29 |
| Effect of Gel Renewal During In-office Dental Bleaching Dental Bleaching with 35% hydrogen peroxide gel + Violet LED Irradiation - Tooth Bleaching | Phase 1 | Unknown | Universidade Ibirapuera | 33 | 2019-03-01 | 2019-07-10 |
| Prevention of Bleaching Induced Sensitivity neutral sodium fluoride, ACP-CCP gel, nano-hydroxyapatite solution - Tooth Bleaching, Tooth Sensitivity | Not applicable | Completed | Medipol University | 64 | 2019-01-07 | 2021-04-28 |
| Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate Toothpaste containing 10% high cleaning silica base, 0.5% sodium phytate and 0.5% sodium pyrophosphate, Control toothpaste - Tooth Bleaching | Not applicable | Completed | Sun Yat-sen University | 86 | 2018-05-07 | 2022-02-23 |
| Clinical Evaluation for Post Bleaching Hypersensitivity Using Desensitizing Agent During In-office Bleaching ACP oral care gel, glycrin - Tooth Bleaching | Not applicable | Completed | Cairo University | 36 | 2017-11-01 | 2019-09-18 |
| Comparison of the Efficacy and Quality of Life of Three Bleaching Products Dental bleaching with PaintOn Plus VivaStyle, Dental Bleaching impact in quality of life with PaintOn Plus Vivastyle, Dental bleaching with Opalescence GO - Tooth Bleaching, Quality of Life | Phase 4 | Unknown | Grupo de Investigação em Bioquímica e Biologia Oral | 90 | 2017-09-01 | 2018-07-17 |
| In-office Bleaching Using a Violet Light 35% Hydrogen peroxide bleaching, 30% Carbamide peroxide bleaching, Violet LED bleaching 1 - Tooth Bleaching, Dentin Sensitivity | Not applicable | Completed | University of Sao Paulo | 200 | 2017-07-02 | 2020-11-04 |
| The Efficacy and Safety of Tooth Bleaching Procedure Using Y10 Whitening Toothpaste and RF Current The Y10 Tooth Whitening system including the Y10 toothpaste and the Y10 device, OTC toothpaste and an unoperated Y10 device - Tooth Bleaching | Not applicable | Withdrawn | Brighttonix Medical Ltd. | 2016-09-01 | 2019-07-10 | |
| Effect of Low-level Laser Therapy on Post-bleaching Sensitivity and Color Change Low-lever laser, Tooth bleaching, Placebo - Tooth Bleaching, Low-level Laser Therapy | Not applicable | Completed | Universidade Federal do Para | 21 | 2016-07-11 | 2018-05-02 |
| Combined Bleaching Technique: Efficacy and Tooth Sensitivity Combined Bleaching(2x20), Combined Bleaching(2x20) with arginine, Combined Bleaching (1x20) - Tooth Bleaching, Tooth Sensitivity | Phase 4 | Completed | Terezinha de Jesus Esteves Barata | 108 | 2016-04-01 | 2019-08-05 |
| Evaluation of Sensitivity With and Without Sonic Activation of a Desensitizing Gel Before in Office Bleaching in Adults With sonic activation (SMART Device®), Control (Without sonic activation) - Dentin Sensitivity, Tooth Bleaching | Not applicable | Completed | Federal University of Amazonas | 31 | 2016-01-18 | 2017-02-01 |
| Naproxen on Tooth Sensitivity Caused by In-office Bleaching Naproxen - Toothache, Tooth Bleaching | Not applicable | Completed | Universidade Federal de Sergipe | 50 | 2015-05-01 | 2016-10-26 |
| Safety and Efficacy of a 6% Hydrogen Peroxide Tooth Bleaching Agent 6% hydrogen peroxide, 35% hydrogen peroxide - Tooth Bleaching | Not applicable | Completed | University of Chile | 31 | 2014-07-01 | 2017-11-22 |
Dentin Sensitivity (7) · Pain (4) · Hypersensitivity (1) · Toothache (1)
Stomatognathic Diseases (8) · Tooth Diseases (8) · Neurologic Manifestations (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Facial Pain (1) · Immune System Diseases (1) · Pain (1)
Tooth Bleaching (2) · Arginine (1) · Calcium Carbonate (1) · Gels (1) · Glycerol (1) · Hydrogen Peroxide (1) · Low-Level Light Therapy (1) · Naproxen (1) · Phytic Acid (1) · Quality of Life (1) · Sodium Fluoride (1) · Vivastyle (1) · guanylyl-(3'-5')-guanosine (1) · potassium nitrate (1) · sodium pyrophosphate (1)
Universidade Federal do Para (7) · Sun Yat-sen University (2) · Brighttonix Medical Ltd. (1) · Cairo University (1) · Federal University of Amazonas (1) · Fujian Medical University (1) · Grupo de Investigação em Bioquímica e Biologia Oral (1) · Medipol University (1) · Terezinha de Jesus Esteves Barata (1) · Universidade Federal de Sergipe (1) · Universidade Ibirapuera (1) · University of Chile (1) · University of Sao Paulo (1)
Brazil (11) · China (3) · Egypt (1) · Portugal (1) · Turkey (Türkiye) (1)
Benin Dikmen, Dr. (1) · Cecy M Silva (1) · Cecy M Silva, doctor (1) · Eduardo Fernandez (1) · Hao Yu, PhD (1) · Hongchun Liu (1) · Hongchun Liu, Ph.D. (1) · Patricia Freitas, PhD (1)