5 recruiting, 1 active not recruiting, 1 completed. 2 Phase 1, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Stage IIA Rectal Cancer AJCC v8: new trials by email Literature Review of Stage IIA Rectal Cancer AJCC v8 trials Research Report on Stage IIA Rectal Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| Active Surveillance and Chemotherapy Before Surgery in Treating Participants With Stage II-III Rectal Cancer Chemotherapy, Patient Observation, Questionnaire Administration - Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8 | Early Phase 1 | Recruiting | M.D. Anderson Cancer Center | 120 | 2024-03-13 | 2026-05-20 |
| Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer Biopsy, Biospecimen Collection, Electronic Health Record Review - Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8 | Recruiting | OHSU Knight Cancer Institute | 50 | 2021-09-03 | 2026-09-16 | |
| Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer Capecitabine, Fluorouracil, Intensity-Modulated Radiation Therapy - Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 25 | 2021-02-11 | 2026-03-30 |
| TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer 3-Dimensional Conformal Radiation Therapy, Intensity-Modulated Radiation Therapy, Trifluridine and Tipiracil Hydrochloride - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 1 | Completed | OHSU Knight Cancer Institute | 19 | 2019-12-11 | 2026-08-06 |
| Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment Quality-of-Life Assessment, Questionnaire Administration - Stage I Colon Cancer AJCC v8, Stage I Rectal Cancer AJCC v8 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 565 | 2018-06-11 | 2026-09-25 | |
| Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer Quality-of-Life Assessment, Questionnaire Administration - Rectal Adenocarcinoma, Stage I Rectal Cancer AJCC v8 | Recruiting | M.D. Anderson Cancer Center | 430 | 2014-05-16 | 2026-08-31 |
Rectal Neoplasms (7) · Colonic Neoplasms (1)
Colorectal Neoplasms (7) · Digestive System Diseases (7) · Digestive System Neoplasms (7) · Gastrointestinal Diseases (7) · Gastrointestinal Neoplasms (7) · Intestinal Diseases (7) · Intestinal Neoplasms (7) · Neoplasms (7) · Neoplasms by Site (7) · Rectal Diseases (7) · Colonic Diseases (1)
Biopsy (2) · Capecitabine (2) · Fluorouracil (2) · Leucovorin (2) · Oxaliplatin (2) · Radiotherapy, Intensity-Modulated (2) · dehydroftorafur (2) · Drug Therapy (1) · Endoscopic Mucosal Resection (1) · Endoscopy (1) · Magnetic Resonance Spectroscopy (1) · Observation (1) · Proctectomy (1) · Radiation (1) · Radiotherapy (1)
M.D. Anderson Cancer Center (2) · OHSU Knight Cancer Institute (2) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · Jonsson Comprehensive Cancer Center (1)
United States (7)
Adel Kardosh, M.D.,Ph.D. (1) · Ann Raldow (1) · Charles D Lopez, MD, PhD (1) · George Chang (1) · George J Chang (1) · Marwan Fakih (1) · Sheetal Kircher (1)
PMID 38194233, PMID 39287948, PMID 41781240
K07CA133187 (1), P30CA033572 (1), U10CA180820 (1), UG1CA189828 (1)