6 recruiting, 2 not yet recruiting, 1 active not recruiting. 4 Phase 2, 3 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 3, Active not recruiting 1 |
| Not applicable | 3 | Not yet recruiting 2, Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Soft Tissue Sarcoma of the Trunk and Extremities: new trials by email Literature Review of Soft Tissue Sarcoma of the Trunk and Extremities trials Research Report on Soft Tissue Sarcoma of the Trunk and Extremities
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Surgical Timing After Preoperative Hypofractionated Radiotherapy for Localized Extremity and Trunk Soft Tissue Sarcoma hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 1-2 weeks after treatment, hypofractionated radiotherapy (30Gy/5 fractions) and surgical resection at 4-6 weeks after treatment - Soft Tissue Sarcoma of the Trunk and Extremities | Not applicable | Not yet recruiting | Italian Sarcoma Group | 142 | 2027-01-30 | 2026-09-02 |
| Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Computed Tomography - Recurrent Soft Tissue Sarcoma of the Trunk and Extremities, Resectable Soft Tissue Sarcoma of the Trunk and Extremities | Phase 3 | Recruiting | SWOG Cancer Research Network | 296 | 2026-12-02 | 2026-10-13 |
| Assessment of the Long-term Efficacy of Moderately Hypofractionated Neoadjuvant Radiotherapy Soft Tissue Sarcoma in the Limbs or Trunk Wall Moderately hypofractionated neoadjuvant radiotherapy - Soft Tissue Sarcoma Adult, Soft Tissue Sarcoma (Excluding GIST) | Phase 2 | Recruiting | Centre Oscar Lambret | 135 | 2026-07-21 | 2026-07-23 |
| Dose-escalated, Hypofractionated, Definitive Proton Radiotherapy for Patients With Inoperable Soft Tissue Sarcoma. Definitive radiotherapy - Soft Tissue Sarcoma (STS), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 40 | 2026-01-26 | 2026-01-28 |
| Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma preoperative, Quality of life, Functional outcome - Soft Tissue Sarcoma (Excluding GIST), Soft Tissue Sarcoma Adult | Phase 2 | Recruiting | Oslo University Hospital | 110 | 2026-01-26 | 2026-01-28 |
| Fluorescence-Guided Optimization of Sarcoma Margins Fluorescent-guided Surgery - Soft Tissue Sarcoma of the Trunk and Extremities, Sarcoma | Not applicable | Recruiting | University of Aarhus | 90 | 2025-09-01 | 2026-07-01 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| Precision Medicine Approaches for Neoadjuvant Therapy in High-risk Sarcoma Patients Observational Translational Study - Sarcoma, Sarcoma, Leiomyo-, Adult | Recruiting | Royal Marsden NHS Foundation Trust | 800 | 2021-11-19 | 2026-02-25 | |
| Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery Biopsy Procedure, Biospecimen Collection, Magnetic Resonance Imaging - Leiomyosarcoma, Liposarcoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 40 | 2019-12-31 | 2026-09-25 |
Sarcoma (7) · Leiomyosarcoma (5) · Liposarcoma (5) · Histiocytoma, Malignant Fibrous (4) · Dermatofibrosarcoma (3) · Sarcoma, Synovial (3) · Hemangiosarcoma (2) · Chondrosarcoma, Extraskeletal Myxoid (1) · Fibrosarcoma (1) · Neurofibrosarcoma (1) · Sarcoma, Alveolar Soft Part (1) · Sarcoma, Clear Cell (1)
Neoplasms (7) · Neoplasms by Histologic Type (7) · Neoplasms, Connective and Soft Tissue (7) · Neoplasms, Adipose Tissue (5) · Neoplasms, Muscle Tissue (5) · Histiocytoma (4) · Neoplasms, Connective Tissue (4) · Neoplasms, Fibrous Tissue (4) · Fibrosarcoma (2) · Neoplasms, Vascular Tissue (2) · Neoplasms, Nerve Tissue (1) · Nerve Sheath Neoplasms (1) · Nervous System Diseases (1) · Nervous System Neoplasms (1) · Neurofibroma (1)
Biopsy (2) · Magnetic Resonance Spectroscopy (2) · Specimen Handling (2) · Aftercare (1) · Quality of Life (1) · Radiation (1) · Radiotherapy (1) · Radiotherapy, Conformal (1) · Radiotherapy, Intensity-Modulated (1) · Surgical Procedures, Operative (1) · X-Rays (1) · talimogene laherparepvec (1)
Oslo University Hospital (2) · Centre Oscar Lambret (1) · ECOG-ACRIN Cancer Research Group (1) · Italian Sarcoma Group (1) · National Cancer Institute (NCI) (1) · Royal Marsden NHS Foundation Trust (1) · SWOG Cancer Research Network (1) · University of Aarhus (1)
Norway (2) · United States (2) · Canada (1) · Denmark (1) · France (1) · United Kingdom (1)
Ivar Hompland, MD, PhD (2) · Kjetil Boye, MD, PhD (2) · Christian Kveller, MD (1) · Jeremy P Harris (1) · Kenneth Cardona (1) · Marco Baia, MD (1) · Robin Jones, MD (1) · Steven I Robinson (1) · Thomas Baad-Hansen, MD, PhD (1)
U10CA180888 (1), UG1CA189828 (1), UM1CA186686 (1), UM1CA186709 (1)