11 completed, 6 terminated, 2 withdrawn. 7 Phase 1, 6 Phase 2, 2 Early Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 4, Terminated 3 |
| Phase 2 | 6 | Completed 3, Terminated 2, Withdrawn 1 |
| Early Phase 1 | 2 | Terminated 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
Follow Signet Ring Adenocarcinoma of the Colon: new trials by email Literature Review of Signet Ring Adenocarcinoma of the Colon trials Research Report on Signet Ring Adenocarcinoma of the Colon
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 2 | 2016-01-29 | 2018-02-26 |
| Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer ziv-aflibercept, leucovorin calcium, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Withdrawn | University of Southern California | 2015-03-01 | 2015-05-06 | |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy cytology specimen collection procedure, laboratory biomarker analysis, questionnaire administration - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Terminated | Fox Chase Cancer Center | 6 | 2013-10-01 | 2018-02-07 | |
| Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer irinotecan hydrochloride, alisertib - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | University of California, Davis | 17 | 2013-08-01 | 2019-01-04 |
| Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab panitumumab, irinotecan hydrochloride, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 16 | 2013-02-01 | 2025-02-05 |
| Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care educational intervention, medical chart review - Adenocarcinoma of the Lung, Mucinous Adenocarcinoma of the Colon | Not applicable | Completed | Fox Chase Cancer Center | 1440 | 2013-01-01 | 2017-04-06 |
| Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer aflibercept, oxaliplatin, leucovorin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 56 | 2012-11-14 | 2025-02-05 |
| Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer cholecalciferol, biopsy, protein expression analysis - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Early Phase 1 | Withdrawn | Case Comprehensive Cancer Center | 2012-04-01 | 2014-01-17 | |
| Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies oxaliplatin, irinotecan hydrochloride, leucovorin calcium - Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder | Phase 1 | Completed | University of Chicago | 79 | 2012-03-26 | 2020-05-08 |
| Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal Cancer irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 4 | 2010-10-01 | 2021-12-20 |
| Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surgery cetuximab, dasatinib, therapeutic conventional surgery - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Early Phase 1 | Terminated | National Cancer Institute (NCI) | 9 | 2009-12-01 | 2014-05-23 |
| Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer cetuximab, bevacizumab, oxaliplatin - Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Colon | Phase 2 | Completed | National Cancer Institute (NCI) | 66 | 2004-11-01 | 2015-07-27 |
| A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer erlotinib hydrochloride, fluorouracil, leucovorin calcium - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-06-01 | 2013-09-30 |
| Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer irinotecan hydrochloride, gefitinib, leucovorin calcium - Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | Phase 2 | Terminated | National Cancer Institute (NCI) | 50 | 2002-10-01 | 2013-01-16 |
| Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies Colorectal Carcinoma, Cancer | Completed | asmaa salama ibrahim | 8171 | 2000-01-01 | 2025-05-18 | |
| Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer irinotecan hydrochloride, oxaliplatin, leucovorin calcium - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 3 | Completed | National Cancer Institute (NCI) | 560 | 1999-11-01 | 2013-05-03 |
| Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer fluorouracil, sodium phenylbutyrate, indomethacin - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 46 | 1997-05-01 | 2013-02-01 |
| Edrecolomab in Treating Patients With Stage II Colon Cancer edrecolomab, laboratory biomarker analysis - Mucinous Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Colon | Phase 3 | Completed | National Cancer Institute (NCI) | 2100 | 1997-05-01 | 2026-06-01 |
Colonic Neoplasms (18) · Rectal Neoplasms (17) · Colorectal Neoplasms (3) · Adenocarcinoma of Lung (1) · Bile Duct Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Signet Ring Cell (1) · Gallbladder Neoplasms (1) · Neoplasms (1) · Neoplasms, Unknown Primary (1) · Pancreatic Neoplasms (1) · Stomach Neoplasms (1)
Colonic Diseases (19) · Digestive System Diseases (19) · Digestive System Neoplasms (19) · Gastrointestinal Diseases (19) · Gastrointestinal Neoplasms (19) · Intestinal Diseases (19) · Intestinal Neoplasms (19) · Neoplasms by Site (19) · Neoplasms (18) · Rectal Diseases (18) · Colorectal Neoplasms (16) · Adenocarcinoma (2) · Carcinoma (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2)
Fluorouracil (10) · Leucovorin (8) · Irinotecan (5) · Oxaliplatin (5) · Bevacizumab (2) · Cetuximab (2) · aflibercept (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · 4-phenylbutyric acid (1) · Biopsy (1) · Cholecalciferol (1) · Dasatinib (1) · Early Intervention, Educational (1) · Edrecolomab (1) · Enzyme-Linked Immunosorbent Assay (1)
National Cancer Institute (NCI) (7) · Fox Chase Cancer Center (4) · John Hays (2) · Case Comprehensive Cancer Center (1) · University of California, Davis (1) · University of Chicago (1) · University of Southern California (1) · Wake Forest University Health Sciences (1) · asmaa salama ibrahim (1)
United States (17) · Egypt (1)
Efrat Dotan (2) · John Hays, MD (2) · Afsaneh Barzi (1) · Allyson Ocean (1) · Caio Rocha Lima, MD (1) · Crystal Denlinger, MD (1) · Efrat Dotan, MD (1) · Emily Chan (1) · Hedy Kindler (1) · Henry Pitot (1) · Matthew Kalady, MD (1) · Max Sung (1) · Peter O'Dwyer (1) · Smitha Krishnamurthi, MD (1) · Thomas Colacchio (1)
P30CA006927 (2), N01CM62201 (1), N01CM62204 (1), P30CA012197 (1), P30CA014089 (1), P30CA068485 (1), P30CA093373 (1), U01CA070095 (1), U10CA025224 (1), U10CA031946 (1)