91 completed. 91 Phase 2, 21 Phase 1, 8 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 91 | Completed 91 |
| Phase 1 | 21 | Completed 21 |
| Phase 3 | 8 | Completed 8 |
Follow Sickle Cell Disease: new trials by email Literature Review of Sickle Cell Disease trials Research Report on Sickle Cell Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2) zinc sulfate, Placebo - Sickle Cell Disease | Phase 2 / Phase 3 | Completed | Indiana University | 100 | 2025-02-10 | 2026-01-30 |
| Study of the Effect of Etavopivat on Cerebral Hemodynamic Response in Children With Sickle Cell Disease Etavopivat - Sickle Cell Disease | Phase 2 | Completed | Novo Nordisk A/S | 12 | 2024-03-09 | 2026-04-08 |
| Pharmacokinetics, Pharmacodynamics and Safety of Epeleuton in Patients With Sickle Cell Disease Epeleuton - Sickle Cell Disease | Phase 2 | Completed | Afimmune | 35 | 2024-01-10 | 2026-05-04 |
| Assessing Physical Function in Sickle Cell Patients Taking Voxelotor Voxelotor - Sickle Cell Disease | Phase 2 | Completed | Inova Health Care Services | 6 | 2023-10-23 | 2026-08-31 |
| Hydroxyurea and EPO in Sickle Cell Disease Hydroxyurea, Epoetin Alfa-BioSimilar - Anemia, Sickle Cell, Sickle Cell Disease | Phase 1 / Phase 2 | Completed | Julia Xu | 17 | 2023-05-25 | 2026-01-07 |
| Acceptability of a New Paediatric Formulation of Hydroxycarbamide in Children With Sickle Cell Disease. Hydroxycarbamide - Sickle Cell Disease | Phase 2 | Completed | Theravia | 33 | 2022-07-08 | 2022-11-23 |
| Research Study Investigating How Well NDec Works in People With Sickle Cell Disease NDec - oral decitabine-tetrahydrouridine, HU - Hydroxyurea, Placebo - Sickle Cell Disease | Phase 2 | Completed | Novo Nordisk A/S | 96 | 2022-07-07 | 2026-07-22 |
| A Study of Etavopivat in Patients With Thalassemia or Sickle Cell Disease Etavopivat tablets - Sickle Cell Disease, Thalassemia | Phase 2 | Completed | Forma Therapeutics, Inc. | 53 | 2022-03-28 | 2025-12-16 |
| Pharmacokinetics and Pharmacodynamics of Rifaximin Novel Formulations in Patients With Sickle Cell Disease Low Dose Rifaximin ER, Low Dose Rifaximin DER, High Dose Rifaximin ER - Sickle Cell Disease | Phase 2 | Completed | Bausch Health Americas, Inc. | 44 | 2022-03-22 | 2024-09-19 |
| A Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treatment in Prevention of Vaso-Occlusive Episodes (VOE) in Sickle Cell Disease (SCD) Crovalimab, Placebo - Sickle Cell Disease | Phase 2 | Completed | Hoffmann-La Roche | 95 | 2022-03-09 | 2026-04-30 |
| Interest of Famotidine in Children With Sickle Cell Disease Famotidine 400 mg/50 mL - Sickle Cell Disease | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 30 | 2022-01-12 | 2025-10-08 |
| Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain Guided Relaxation, Acupuncture - Sickle Cell Disease | Phase 2 | Completed | University of Illinois at Chicago | 379 | 2021-11-24 | 2026-03-03 |
| Study to Assess Efficacy and Safety of VIT-2763 (Vamifeport) in Subjects With Sickle Cell Disease VIT-2763 120 mg, VIT-2763 360 mg, VIT-2763 240 mg - Sickle Cell Disease | Phase 2 | Completed | Vifor (International) Inc. | 25 | 2021-11-18 | 2025-02-18 |
| Losartan for Diffuse Myocardial Fibrosis in Sickle Cell Disease Losartan - Sickle Cell Disease, Diffuse Myocardial Fibrosis | Phase 2 | Completed | Children's Hospital Medical Center, Cincinnati | 14 | 2021-09-01 | 2026-06-12 |
| Low Dose Iron Chelation as TReatment of Oxidative Damage in Sickle Cell Disease Deferasirox 360 MG - Sickle Cell Disease | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2021-07-20 | 2023-02-13 |
| Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease Isoquercetin, Placebo - Sickle Cell Disease | Phase 2 | Completed | National Heart, Lung, and Blood Institute (NHLBI) | 46 | 2020-11-02 | 2024-01-02 |
| Daily Vitamin D for Sickle-cell Respiratory Complications Daily oral vitamin D3, 3,333 IU, Monthly oral vitamin D3, 100,000 IU, Placebo oral tablet - Sickle Cell Disease, Anemia, Sickle Cell | Phase 2 | Completed | Columbia University | 58 | 2020-09-15 | 2025-09-24 |
| Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE) DREPAGLOBE drug product - Sickle Cell Disease | Phase 1 / Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 6 | 2019-11-12 | 2026-03-05 |
| Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia Omega 3, Vit D, Zinc sulfate - Vaso-occlusive Crisis, Sickle Cell Disease | Phase 2 / Phase 3 | Completed | Beni-Suef University | 350 | 2019-11-01 | 2021-01-27 |
| Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow Bone Marrow Transplant (BMT), Hydroxyurea, Thiotepa - Sickle Cell Disease | Phase 2 | Completed | Emory University | 10 | 2019-07-10 | 2023-10-12 |
Showing 20 of 91. Sign in to see all of them.
Anemia, Sickle Cell (91) · Anemia (8) · Thalassemia (8) · Vaso-Occlusive Crises (8) · Acute Chest Syndrome (6) · Hemoglobinopathies (5) · beta-Thalassemia (4) · Anemia, Diamond-Blackfan (3) · Anemia, Hemolytic (3) · Genetic Diseases, Inborn (3) · Hematologic Diseases (3) · Pain (3) · Albuminuria (2) · Asthma (2) · Bone Marrow Failure Disorders (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (91) · Hemic and Lymphatic Diseases (91) · Anemia, Hemolytic, Congenital (90) · Anemia, Hemolytic (88) · Genetic Diseases, Inborn (88) · Hematologic Diseases (88) · Hemoglobinopathies (86) · Anemia (83) · Pathological Conditions, Signs and Symptoms (15) · Pathologic Processes (8) · Nutritional and Metabolic Diseases (7) · Signs and Symptoms (7) · Bone Marrow Diseases (6) · Immune System Diseases (6) · Lung Diseases (6)
Hydroxyurea (10) · Bone Marrow Transplantation (7) · Busulfan (7) · Antilymphocyte Serum (6) · fludarabine (6) · fludarabine phosphate (6) · Alemtuzumab (5) · Cyclophosphamide (5) · Whole-Body Irradiation (5) · Cholecalciferol (4) · Deferasirox (3) · Hematopoietic Stem Cell Transplantation (3) · Melphalan (3) · Simvastatin (3) · Thiotepa (3)
Assistance Publique - Hôpitaux de Paris (4) · Medical College of Wisconsin (4) · National Heart, Lung, and Blood Institute (NHLBI) (4) · UCSF Benioff Children's Hospital Oakland (4) · Emory University (3) · Johns Hopkins University (3) · Columbia University (2) · Gary M Brittenham, MD (2) · Genetix Biotherapeutics Inc. (2) · GlycoMimetics Incorporated (2) · HemaQuest Pharmaceuticals Inc. (2) · Jeffrey Glassberg (2) · New York Medical College (2) · Novartis Pharmaceuticals (2) · Novo Nordisk A/S (2)
United States (76) · France (14) · United Kingdom (11) · Canada (9) · Lebanon (7) · Italy (6) · Egypt (4) · Jamaica (4) · Kenya (3) · Turkey (Türkiye) (3) · Brazil (2) · Greece (2) · Netherlands (2) · South Africa (2) · Spain (2)
Claudia Morris, MD (2) · Helen Thackray, MD (2) · Lakshmanan Krishnamurti, MD (2) · Margaret T Lee, MD (2) · Mary Horowitz, MD (2) · Mitchell S Cairo, MD (2) · Ahmed F Mahmoud Hussein, MS.c (1) · Amy Tang, MD (1) · Angela E Rankine- Mullings, MD (1) · Angela Smith, MD (1) · Anjulika Chawla, MD, FAAP (1) · Ardith Doorenbos, PhD, RN, FAAN (1)
PMID 36240296, PMID 34175041, PMID 18192510, PMID 18550258, PMID 21477202, PMID 22129980, PMID 22887019, PMID 22924607, PMID 23416852, PMID 23828223, PMID 24370862, PMID 24443249, PMID 24445353, PMID 24988449, PMID 25733584, PMID 26232172, PMID 26348869, PMID 26431718, PMID 27625358, PMID 27959701, PMID 28249145, PMID 28370266, PMID 28606098, PMID 29669226, PMID 29712666, PMID 30637784, PMID 30655275, PMID 30783732, PMID 32384147, PMID 32678452, PMID 32873924, PMID 32977351, PMID 33283989, PMID 33811823, PMID 34115136, PMID 34724240, PMID 34889382, PMID 34898139, PMID 34922648, PMID 35075288, PMID 35120836, PMID 36123234, PMID 36161320, PMID 36355805, PMID 36529836, PMID 36852100, PMID 36860093, PMID 36975201, PMID 37184905, PMID 37722599
2017 (2), U24CA076518 (2), 1UG3AT011265-01 (1), 3UL1RR025005 (1), K01HL096434 (1), K23HL119351 (1), K23HL136787 (1), K24AT009893 (1), R01HL111659 (1), R01HL142671 (1), R21HL096123 (1), R34HL108761 (1), R44HL093893 (1), U01HL069294 (1), U01HL128568 (1)