2 active not recruiting, 1 completed, 1 suspended, 1 terminated. 2 Phase 2, 1 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Active not recruiting 1, Terminated 1 |
| Not applicable | 1 | Active not recruiting 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 3 | 1 | Suspended 1 |
Follow SCID: new trials by email Literature Review of SCID trials Research Report on SCID
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Conditioning SCID Infants Diagnosed Early Busulfan, Cell processing for TCRαβ+/CD19+ depletion - SCID | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 56 | 2018-10-22 | 2026-10-26 |
| JSP191 Antibody Targeting Conditioning in SCID Patients Humanized anti-CD117 Monoclonal Antibody (JSP191) - SCID | Phase 1 / Phase 2 | Terminated | Jasper Therapeutics, Inc. | 23 | 2017-03-20 | 2025-07-28 |
| Participation in a Research Registry for Immune Disorders Primary Immunodeficiencies, APECED | Completed | National Human Genome Research Institute (NHGRI) | 716 | 2013-09-30 | 2023-07-20 | |
| Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies Alemtuzumab 0.3 mg, Cyclophosphamide, Busulfan - SCID, Omenn's Syndrome | Not applicable | Active not recruiting | Masonic Cancer Center, University of Minnesota | 57 | 2012-09-04 | 2026-06-17 |
| Patients Treated for SCID (1968-Present) SCID, ADA-SCID | Unknown | National Institute of Allergy and Infectious Diseases (NIAID) | 1007 | 2011-05-15 | 2020-11-12 |
Immunologic Deficiency Syndromes (2) · Reticular dysgenesis (2) · Severe Combined Immunodeficiency (2) · Wiskott-Aldrich Syndrome (2) · Anemia, Aplastic (1) · Bone Marrow Failure Disorders (1) · Chediak-Higashi Syndrome (1) · Common Variable Immunodeficiency (1) · Granulomatous Disease, Chronic (1) · Histiocytosis, Langerhans-Cell (1) · Hyper-IgM Immunodeficiency Syndrome (1) · Leukemia (1) · Lymphohistiocytosis, Hemophagocytic (1) · Lymphoproliferative Disorders (1) · Mucositis (1)
Immune System Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3) · Genetic Diseases, X-Linked (3) · Hematologic Diseases (3) · Hemic and Lymphatic Diseases (3) · Blood Coagulation Disorders (2) · Blood Coagulation Disorders, Inherited (2) · Cytopenia (2) · DNA Repair-Deficiency Disorders (2) · Hemorrhagic Disorders (2) · Immunologic Deficiency Syndromes (2) · Infant, Newborn, Diseases (2) · Leukocyte Disorders (2) · Leukopenia (2)
Busulfan (2) · Alemtuzumab (1) · Cyclophosphamide (1) · Hydromorphone (1) · Melphalan (1) · Mesna (1) · Methadone (1) · Morphine (1) · Passive Cutaneous Anaphylaxis (1) · Sodium (1) · Stem Cell Transplantation (1) · fludarabine phosphate (1)
Center for International Blood and Marrow Transplant Research (1) · Jasper Therapeutics, Inc. (1) · Masonic Cancer Center, University of Minnesota (1) · National Human Genome Research Institute (NHGRI) (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · University of Texas Southwestern Medical Center (1)
United States (6) · Canada (2)
Christen L Ebens, M.D., MPH (1) · Christopher C. Dvorak, M.D. (1) · Elie Haddad, MD, PhD (1) · Elizabeth D Hicks, M.D. (1) · Elizabeth K Garabedian, R.N. (1) · Harry L Malech, M.D. (1) · Joseph H. Oved, M.D. (1) · Meera Srikanthan, MD (1) · Michael Pulsipher, MD (1) · Morton J. Cowan, MD (1) · Neena Kapoor, M.D. (1) · Rajni A. Agarwal-Hashmi, M.D. (1) · Richard J. O'Reilly, MD (1) · Shanmuganathan Chandrakasan, M.D. (1) · Sharat Chandra, M.D. (1)
PMID 20004776, PMID 23818196, PMID 24139498, PMID 24290292, PMID 24331379, PMID 25075835, PMID 27262745, PMID 29619656, PMID 29728406, PMID 30154114, PMID 30193840, PMID 30194989, PMID 35671392, PMID 41289158