19 completed, 4 terminated, 3 unknown, 2 recruiting. 19 Phase 2, 11 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 13, Unknown 3, Terminated 2, Recruiting 1 |
| Phase 1 | 11 | Completed 7, Recruiting 2, Terminated 2 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
Follow Recurrent Small Cell Lung Cancer: new trials by email Literature Review of Recurrent Small Cell Lung Cancer trials Research Report on Recurrent Small Cell Lung Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autologous B7-H3 Chimeric Antigen Receptor T Cells in Previously Treated Extensive-Stage Small Cell Lung Cancer With Recurrent or Refractory Disease Autologous B7-H3 CAR T, Cyclophosphamide, Fludarabine - Recurrent Small Cell Lung Cancer, Extensive-Stage Small Cell Lung Cancer | Phase 1 | Recruiting | National Cancer Institute (NCI) | 40 | 2026-10-16 | 2026-10-29 |
| Biomarker Directed Trial of Temozolomide and Stenoparib in Relapsed SCLC Stenoparib/Temozolomide, Lurbinectedin - Relapsed Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | VA Office of Research and Development | 166 | 2026-02-23 | 2026-03-11 |
| The Efficacy and Safety of Radiotherapy Plus Niraparib and Toripalimab in Patients With Recurrent Small Cell Lung Cancer SBRT, Toripalimab, Niraparib - Recurrent Small Cell Lung Cancer | Phase 2 | Unknown | Wuhan University | 57 | 2022-06-01 | 2022-05-02 |
| Immune Checkpoint Inhibition With Lurbinectedin Relapsed/Recurrent SCLC Nivolumab, Ipilimumab, Lurbinectedin - Small-cell Lung Cancer, Relapsed Small Cell Lung Cancer | Phase 1 | Terminated | H. Lee Moffitt Cancer Center and Research Institute | 9 | 2020-11-23 | 2024-04-02 |
| Anlotinib in Treatment of Recurrent Small Cell Lung Cancer Anlotinib - Recurrent Small Cell Lung Cancer | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 43 | 2018-11-01 | 2018-11-07 |
| Impacts of Exercise on Prognostic Biomarkers in Lung Cancer Patients exercise intervention, standard follow-up care, quality-of-life assessment - Extensive Stage Small Cell Lung Cancer, Healthy, no Evidence of Disease | Not applicable | Completed | University of Wisconsin, Madison | 21 | 2013-12-01 | 2019-11-18 |
| CPI-613 in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer 6,8-bis(benzylthio)octanoic acid - Recurrent Small Cell Lung Cancer | Phase 1 | Completed | Wake Forest University Health Sciences | 15 | 2013-10-01 | 2018-07-03 |
| Study of Ponatinib in Patients With Lung Cancer Preselected Using Different Candidate Predictive Biomarkers Ponatinib - Adenocarcinoma of the Lung, Extensive Stage Small Cell Lung Cancer | Phase 2 | Completed | University of Colorado, Denver | 171 | 2013-09-24 | 2022-02-11 |
| Rovalpituzumab Tesirine (SC16LD6.5) in Recurrent Small Cell Lung Cancer Rovalpituzumab tesirine (SC16LD6.5) - Recurrent Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Stemcentrx | 82 | 2013-07-01 | 2018-08-09 |
| Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer topotecan hydrochloride, cyclodextrin-based polymer-camptothecin CRLX101 - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Terminated | University of Chicago | 29 | 2013-01-16 | 2020-06-26 |
| Cryotherapy in Treating Patients With Lung Cancer That Has Spread to the Other Lung or Parts of the Body cryotherapy, quality-of-life assessment - Advanced Malignant Mesothelioma, Extensive Stage Small Cell Lung Cancer | Not applicable | Withdrawn | Wake Forest University Health Sciences | 2011-03-01 | 2018-07-03 | |
| Enhanced Quitline Intervention in Smoking Cessation for Patients With Non-Metastatic Lung Cancer questionnaire administration, quality-of-life assessment, counseling intervention - Limited Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 1 | Completed | Wake Forest University Health Sciences | 6 | 2011-01-01 | 2018-08-01 |
| Temsirolimus and Vinorelbine Ditartrate in Treating Patients With Unresectable or Metastatic Solid Tumors temsirolimus, vinorelbine ditartrate - Extensive Stage Small Cell Lung Cancer, Hereditary Paraganglioma | Phase 1 | Completed | University of Southern California | 19 | 2010-06-01 | 2016-06-13 |
| S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer ziv-aflibercept, topotecan hydrochloride - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 189 | 2009-05-01 | 2017-08-21 |
| R-(-)-Gossypol Acetic Acid in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer R-(-)-gossypol acetic acid, pharmacological study, laboratory biomarker analysis - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 15 | 2008-11-01 | 2014-05-12 |
| AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer saracatinib - Extensive Stage Small Cell Lung Cancer, Lung Metastases | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2007-11-01 | 2017-12-07 |
| Obatoclax Mesylate and Topotecan Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer or Advanced Solid Tumors obatoclax mesylate, topotecan hydrochloride, laboratory biomarker analysis - Recurrent Small Cell Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 22 | 2007-08-01 | 2015-05-05 |
| Dasatinib in Treating Patients With Relapsed Small Cell Lung Cancer dasatinib - Extensive Stage Small Cell Lung Cancer, Limited Stage Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 44 | 2007-04-01 | 2015-05-05 |
| Sorafenib in Treating Patients With Extensive Stage Small Cell Lung Cancer sorafenib tosylate - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 89 | 2005-07-01 | 2014-05-21 |
| 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer topotecan hydrochloride, 7-hydroxystaurosporine - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 19 | 2005-01-01 | 2018-07-23 |
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Small Cell Lung Carcinoma (29) · Carcinoma, Non-Small-Cell Lung (9) · Breast Neoplasms (3) · Carcinoma, Ovarian Epithelial (3) · Endometrial Neoplasms (3) · Breast Neoplasms, Male (2) · Colonic Neoplasms (2) · Lung Neoplasms (2) · Neoplasms (2) · Prostatic Neoplasms (2) · Rectal Neoplasms (2) · Stomach Neoplasms (2) · Uterine Cervical Neoplasms (2) · Adenocarcinoma of Lung (1) · Anus Neoplasms (1)
Bronchial Neoplasms (29) · Carcinoma, Bronchogenic (29) · Lung Diseases (29) · Neoplasms by Site (29) · Respiratory Tract Diseases (29) · Respiratory Tract Neoplasms (29) · Thoracic Neoplasms (29) · Lung Neoplasms (27) · Neoplasms (27) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Carcinoma (5) · Adenocarcinoma (4) · Digestive System Diseases (4) · Digestive System Neoplasms (4)
Topotecan (4) · trioctyl phosphine oxide (4) · 7-hydroxystaurosporine (2) · PM 01183 (2) · romidepsin (2) · Bendamustine Hydrochloride (1) · Carboplatin (1) · Counseling (1) · Cryotherapy (1) · Cyclophosphamide (1) · Dasatinib (1) · Docetaxel (1) · Early Intervention, Educational (1) · Etoposide (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1)
National Cancer Institute (NCI) (16) · Wake Forest University Health Sciences (3) · Charite University, Berlin, Germany (1) · H. Lee Moffitt Cancer Center and Research Institute (1) · Peking University Cancer Hospital & Institute (1) · Stemcentrx (1) · University of Chicago (1) · University of Colorado, Denver (1) · University of Southern California (1) · University of Wisconsin, Madison (1) · VA Office of Research and Development (1) · Wuhan University (1)
United States (24) · Canada (1) · China (1) · Germany (1)
Ravi Salgia (2) · Afshin Dowlati (1) · Agustin Garcia (1) · Alberto A Chiappori, MD (1) · Alex Adjei (1) · Antonius Miller (1) · Barbara Gitlitz (1) · David S. Schrump (1) · Donald Strickland, MD (1) · Glennwood Goss (1) · Gregory Otterson (1) · James Urbanic (1) · Jeffrey Allen (1) · Jian Fang (1) · Jimmy Ruiz (1)
PMID 25490004, PMID 21620511, PMID 25002722, PMID 27932068
U10CA031946 (3), P30CA014236 (2), U10CA025224 (2), N01CM62203 (1), N01CM62205 (1), N01CM62209 (1), P30CA012197 (1), P30CA014520 (1), P30CA015083 (1), P30CA043703 (1), P30CA044579 (1), P30CA051008 (1), R01CA088972 (1), U01CA062502 (1), U01CA076576 (1)