13 completed, 2 terminated, 1 active not recruiting, 1 withdrawn. 9 Phase 2, 5 Phase 1, 2 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 6, Terminated 2, Active not recruiting 1 |
| Phase 1 | 5 | Completed 5 |
| Not applicable | 2 | Completed 1, Withdrawn 1 |
| Phase 3 | 2 | Completed 2 |
Follow trioctyl phosphine oxide: new trials by email Literature Review of trioctyl phosphine oxide trials Research Report on trioctyl phosphine oxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma etoposide, ifosfamide, intensity-modulated radiation therapy - Adult Supratentorial Primitive Neuroectodermal Tumor (PNET), Ewing Sarcoma of Bone | Not applicable | Withdrawn | City of Hope Medical Center | 2013-07-01 | 2015-01-09 | |
| Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma vincristine, topotecan, filgrastim - Retinoblastoma | Phase 2 | Active not recruiting | St. Jude Children's Research Hospital | 174 | 2013-06-19 | 2026-06-29 |
| Topotecan Hydrochloride or Cyclodextrin-Based Polymer-Camptothecin CRLX101 in Treating Patients With Recurrent Small Cell Lung Cancer topotecan hydrochloride, cyclodextrin-based polymer-camptothecin CRLX101 - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Terminated | University of Chicago | 29 | 2013-01-16 | 2020-06-26 |
| S0802 - Topotecan With or Without Aflibercept in Treating Patients With Extensive-Stage Small Cell Lung Cancer ziv-aflibercept, topotecan hydrochloride - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 189 | 2009-05-01 | 2017-08-21 |
| Comparing Three Different Combination Chemotherapy Regimens in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia alvocidib, mitoxantrone hydrochloride, carboplatin - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Phase 2 | Completed | National Cancer Institute (NCI) | 92 | 2008-10-01 | 2015-07-07 |
| Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors radiation therapy, therapeutic conventional surgery, etoposide - Ewing Sarcoma of Bone, Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Not applicable | Completed | Children's Oncology Group | 35 | 2008-03-01 | 2014-09-25 |
| Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma topotecan hydrochloride, vincristine sulfate, cyclophosphamide - Ewing Sarcoma of Bone, Extraosseous Ewing Sarcoma | Phase 2 | Completed | National Cancer Institute (NCI) | 7 | 2008-02-01 | 2014-09-02 |
| Obatoclax Mesylate and Topotecan Hydrochloride in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer or Advanced Solid Tumors obatoclax mesylate, topotecan hydrochloride, laboratory biomarker analysis - Recurrent Small Cell Lung Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 22 | 2007-08-01 | 2015-05-05 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
| Oxaliplatin and Topotecan in Advance Ovarian Cancer oxaliplatin, topotecan - Recurrent Ovarian Epithelial Cancer | Phase 2 | Terminated | National Cancer Institute (NCI) | 39 | 2006-01-01 | 2015-11-27 |
| 7-hydroxystaurosporine and Topotecan Hydrochloride in Treating Patients With Relapsed or Progressed Small Cell Lung Cancer topotecan hydrochloride, 7-hydroxystaurosporine - Extensive Stage Small Cell Lung Cancer, Recurrent Small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 19 | 2005-01-01 | 2018-07-23 |
| Bortezomib and Topotecan Hydrochloride in Treating Patients With Advanced Solid Tumors bortezomib, topotecan hydrochloride, immunohistochemistry staining method - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | City of Hope Medical Center | 54 | 2004-03-03 | 2026-10-22 |
| A Dose Finding Phase I Trial of the Combination of Topotecan and PS-341, a Novel Proteasome Inhibitor, in Advanced Malignancies topotecan hydrochloride, bortezomib, pharmacological study - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | National Cancer Institute (NCI) | 25 | 2003-07-01 | 2013-02-01 |
| Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma dactinomycin, vincristine sulfate, cyclophosphamide - Adult Malignant Mesenchymoma, Adult Rhabdomyosarcoma | Phase 3 | Completed | Children's Oncology Group | 702 | 2002-09-01 | 2013-06-17 |
| Combination Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer or Primary Peritoneal Cancer Paclitaxel, Carboplatin, Gemcitabine Hydrochloride - Primary Peritoneal Carcinoma, Stage III Ovarian Cancer | Phase 3 | Completed | Gynecologic Oncology Group | 4312 | 2001-01-01 | 2019-04-16 |
| Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment topotecan hydrochloride, laboratory biomarker analysis - AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 77 | 2000-04-01 | 2013-02-21 |
| Paclitaxel, Cisplatin, and Topotecan With or Without Filgrastim in Treating Patients With Newly Diagnosed Stage III or Stage IV Epithelial Ovarian Cancer paclitaxel, cisplatin, topotecan hydrochloride - Brenner Tumor, Ovarian Clear Cell Cystadenocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 1996-12-01 | 2013-01-24 |
Neuroectodermal Tumors, Primitive, Peripheral (4) · Small Cell Lung Carcinoma (4) · Carcinoma, Ovarian Epithelial (2) · Medulloblastoma (2) · Rhabdomyosarcoma (2) · Sarcoma (2) · Astrocytoma (1) · Brain Neoplasms (1) · Brenner Tumor (1) · Burkitt Lymphoma (1) · Congenital Abnormalities (1) · Dendritic Cell Sarcoma, Interdigitating (1) · Familial ependymoma (1) · Leukemia, Erythroblastic, Acute (1) · Leukemia, Megakaryoblastic, Acute (1)
National Cancer Institute (NCI) (9) · City of Hope Medical Center (3) · Children's Oncology Group (2) · Gynecologic Oncology Group (1) · St. Jude Children's Research Hospital (1) · University of Chicago (1)
United States (16) · Canada (1) · Israel (1)
Amy Tiersten (1) · Anna Pawlowska (1) · Anna Pawlowska, MD (1) · Carlos Rodriguez-Galindo, MD (1) · Carola Arndt (1) · Deborah Armstrong (1) · Glennwood Goss (1) · Jeffrey Allen (1) · John Murren (1) · Lee Krug (1) · Leo Mascarenhas, MD MS (1) · Mark Litzow (1) · Michael Bookman (1) · Mihaela Cristea, MD (1) · Patrick Leavey, MD (1)
PMID 21620511, PMID 23969788, PMID 24172094, PMID 24779680, PMID 25002722, PMID 25490004, PMID 30633128, PMID 37148580, PMID 37229879, PMID 38603649
U10CA098543 (4), U10CA027469 (2), N01CM62203 (1), N01CM62204 (1), R21CA097750 (1), U10CA021115 (1)