10 completed, 1 terminated. 11 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 10, Terminated 1 |
Follow Recurrent Childhood Visual Pathway and Hypothalamic Glioma: new trials by email Literature Review of Recurrent Childhood Visual Pathway and Hypothalamic Glioma trials Research Report on Recurrent Childhood Visual Pathway and Hypothalamic Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
| Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma ispinesib, laboratory biomarker analysis, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2006-06-01 | 2013-01-16 |
| Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors lenalidomide, perfusion-weighted magnetic resonance imaging, diffusion-weighted magnetic resonance imaging - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 45 | 2004-11-01 | 2013-09-30 |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
| FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia romidepsin - Blastic Phase Chronic Myelogenous Leukemia, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2002-09-01 | 2013-01-16 |
| Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas alvocidib, pharmacological study - Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2001-04-01 | 2013-07-02 |
Astrocytoma (11) · Familial ependymoma (11) · Medulloblastoma (11) · Optic Nerve Glioma (11) · Choroid Plexus Neoplasms (9) · Oligodendroglioma (7) · Spinal Cord Neoplasms (5) · Burkitt Lymphoma (4) · Dendritic Cell Sarcoma, Interdigitating (4) · Rhabdoid Tumor (4) · Recurrence (3) · Lymphoma, Large-Cell, Anaplastic (2) · Neuroblastoma (2) · Neuroectodermal Tumors, Primitive, Peripheral (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2)
Cranial Nerve Diseases (11) · Cranial Nerve Neoplasms (11) · Eye Diseases (11) · Glioma (11) · Neoplasms (11) · Neoplasms by Histologic Type (11) · Neoplasms by Site (11) · Neoplasms, Germ Cell and Embryonal (11) · Neoplasms, Glandular and Epithelial (11) · Neoplasms, Nerve Tissue (11) · Neoplasms, Neuroepithelial (11) · Nervous System Diseases (11) · Nervous System Neoplasms (11) · Neuroectodermal Tumors (11) · Neuroectodermal Tumors, Primitive (11)
Temozolomide (3) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · Vorinostat (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Bone Marrow Transplantation (1) · Bortezomib (1) · Busulfan (1) · CK0238273 (1) · Calcium Dobesilate (1) · Cilengitide (1) · Dexamethasone (1) · Lenalidomide (1) · Melphalan (1) · O(6)-benzylguanine (1)
National Cancer Institute (NCI) (10) · City of Hope Medical Center (1)
United States (11) · Canada (2)
Amar Gajjar (1) · Anna Pawlowska, MD (1) · Jack Su (1) · James Whitlock (1) · Jodi Muscal (1) · Katherine Warren (1) · Maryam Fouladi (1) · Najat Daw (1) · Richard Sills (1) · Tobey MacDonald (1) · Trent Hummel (1)
U01CA097452 (6), U01CA081457 (4)