18 completed, 3 terminated, 1 withdrawn. 17 Phase 1, 4 Phase 2, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 17 | Completed 15, Terminated 2 |
| Phase 2 | 4 | Completed 4 |
| Not applicable | 2 | Terminated 1, Withdrawn 1 |
Follow Recurrent Childhood Brain Stem Glioma: new trials by email Literature Review of Recurrent Childhood Brain Stem Glioma trials Research Report on Recurrent Childhood Brain Stem Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Laboratory Biomarker Analysis, Pharmacological Study, Pomalidomide - Neurofibromatosis Type 1, Recurrent Childhood Brain Stem Glioma | Phase 1 | Completed | National Cancer Institute (NCI) | 29 | 2015-07-14 | 2022-04-25 |
| Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors palbociclib isethionate, pharmacological study, laboratory biomarker analysis - Childhood Choroid Plexus Tumor, Childhood Ependymoblastoma | Phase 1 | Terminated | Pediatric Brain Tumor Consortium | 35 | 2014-12-08 | 2021-03-02 |
| 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas 18F-fluoro-dihydroxyphenylalanine, Positron emission tomography (PET), Computed tomography (CT) - Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma | Not applicable | Terminated | Erik Mittra | 2 | 2014-12-01 | 2017-03-20 |
| Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors gallium Ga 68-edotreotide, positron emission tomography, computed tomography - Acoustic Schwannoma, Adult Anaplastic Astrocytoma | Not applicable | Withdrawn | Sue O'Dorisio | 2013-09-01 | 2017-04-28 | |
| Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia gamma-secretase/Notch signalling pathway inhibitor RO4929097, diagnostic laboratory biomarker analysis, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 129 | 2010-03-01 | 2014-11-05 |
| Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors vorinostat, temozolomide, diagnostic laboratory biomarker analysis - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 27 | 2010-02-01 | 2013-05-03 |
| Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma vorinostat, bortezomib, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Choriocarcinoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2009-08-01 | 2013-07-02 |
| ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors veliparib, temozolomide, pharmacological study - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 31 | 2009-07-01 | 2014-07-09 |
| Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment pazopanib hydrochloride, pharmacological study - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2009-06-01 | 2013-09-30 |
| Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor busulfan, melphalan, topotecan hydrochloride - Solid Tumor, Adult Central Nervous System Germ Cell Tumor | Phase 1 | Completed | City of Hope Medical Center | 25 | 2007-02-26 | 2025-03-20 |
| Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Bevacizumab, Fludeoxyglucose F-18, Irinotecan Hydrochloride - Childhood Cerebral Anaplastic Astrocytoma, Childhood Oligodendroglioma | Phase 2 | Completed | National Cancer Institute (NCI) | 97 | 2006-08-01 | 2017-11-28 |
| Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma ispinesib, laboratory biomarker analysis, pharmacological study - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 30 | 2006-06-01 | 2013-01-16 |
| AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Cediranib Maleate - Childhood Atypical Teratoid/Rhabdoid Tumor, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 55 | 2006-03-01 | 2016-03-07 |
| Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors oxaliplatin, fluorouracil, leucovorin calcium - Childhood Central Nervous System Choriocarcinoma, Childhood Central Nervous System Embryonal Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 42 | 2005-09-01 | 2013-05-03 |
| Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas irinotecan hydrochloride, oxaliplatin - Childhood Burkitt Lymphoma, Childhood Central Nervous System Germ Cell Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2013-06-05 |
| Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment oxaliplatin - Childhood Central Nervous System Germ Cell Tumor, Childhood Extragonadal Germ Cell Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 180 | 2004-10-01 | 2013-06-05 |
| Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors lapatinib ditosylate, therapeutic conventional surgery, laboratory biomarker analysis - Recurrent Childhood Anaplastic Astrocytoma, Recurrent Childhood Brain Stem Glioma | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 52 | 2004-10-01 | 2014-05-23 |
| Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma tipifarnib - Childhood High-grade Cerebral Astrocytoma, Childhood Oligodendroglioma | Phase 2 | Completed | National Cancer Institute (NCI) | 90 | 2003-11-01 | 2013-10-08 |
| Cilengitide in Treating Children With Refractory Primary Brain Tumors cilengitide, laboratory biomarker analysis - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-09-30 |
| Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors O6-benzylguanine, temozolomide, filgrastim - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 1 | Completed | National Cancer Institute (NCI) | 72 | 2002-10-01 | 2013-09-30 |
Showing 20 of 22. Sign in to see all of them.
Astrocytoma (18) · Optic Nerve Glioma (18) · Medulloblastoma (17) · Familial ependymoma (16) · Oligodendroglioma (13) · Choroid Plexus Neoplasms (10) · Spinal Cord Neoplasms (7) · Burkitt Lymphoma (5) · Dendritic Cell Sarcoma, Interdigitating (5) · Glioblastoma (4) · Neuroblastoma (4) · Neuroectodermal Tumors, Primitive, Peripheral (4) · Recurrence (4) · Rhabdoid Tumor (4) · Brain Neoplasms (3)
Neoplasms (21) · Neoplasms by Histologic Type (21) · Neoplasms, Germ Cell and Embryonal (21) · Neoplasms, Glandular and Epithelial (21) · Neoplasms, Nerve Tissue (21) · Neuroectodermal Tumors (21) · Neoplasms by Site (20) · Nervous System Diseases (20) · Nervous System Neoplasms (20) · Glioma (19) · Cranial Nerve Diseases (18) · Cranial Nerve Neoplasms (18) · Eye Diseases (18) · Neoplasms, Neuroepithelial (18) · Optic Nerve Diseases (18)
2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (4) · Magnetic Resonance Spectroscopy (4) · Oxaliplatin (3) · Temozolomide (3) · Filgrastim (2) · Granulocyte Colony-Stimulating Factor (2) · Irinotecan (2) · Vorinostat (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Bevacizumab (1) · Bone Marrow Transplantation (1) · Bortezomib (1) · Busulfan (1) · CK0238273 (1) · Calcium Dobesilate (1)
National Cancer Institute (NCI) (18) · City of Hope Medical Center (1) · Erik Mittra (1) · Pediatric Brain Tumor Consortium (1) · Sue O'Dorisio (1)
United States (22) · Canada (2)
Maryam Fouladi (3) · Amar Gajjar (1) · Anna Pawlowska, MD (1) · David Van Mater, MD (1) · Erik Mittra, MD, PhD (1) · Jack Su (1) · James Whitlock (1) · Jason R Fangusaro (1) · Jodi Muscal (1) · Julia Glade-Bender (1) · Lia Gore (1) · Lisa McGregor (1) · M. Sue O'Dorisio, MD, PhD (1) · Mark Kieran (1) · Najat Daw (1)
PMID 23554030, PMID 23857966, PMID 37553297
U01CA097452 (8), U01CA081457 (7), U10CA098543 (2), P30CA086862 (1), P30CA124435 (1), UM1CA081457 (1)