12 completed, 5 recruiting, 1 terminated. 13 Not applicable, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 9, Recruiting 3, Terminated 1 |
| Phase 2 | 2 | Recruiting 2 |
| Phase 1 | 1 | Completed 1 |
Follow Provoked Vestibulodynia: new trials by email Literature Review of Provoked Vestibulodynia trials Research Report on Provoked Vestibulodynia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Dry Needling in Reducing Pain During Sexual Intercourse Real dry needling, Sham dry needling - Provoked Vestibulodynia | Not applicable | Recruiting | Université de Sherbrooke | 170 | 2026-05-11 | 2026-05-12 |
| IncobotulinumtoxinA for Provoked Vestibulodynia With Overactive Pelvic Floor Muscle Dysfunction Incobotulinum Toxin A, Placebo - Provoked Vestibulodynia | Phase 2 | Recruiting | Center for Vulvovaginal Disorders | 54 | 2026-02-27 | 2026-03-23 |
| Topical Ketotifen 0.25% for Secondary Vestibulodynia Ketotifen Fumarate 0.25% Cream, Placebo (Vehicle Cream) - Provoked Vestibulodynia, Secondary Provoked Vestibulodynia | Phase 2 | Recruiting | Center for Vulvovaginal Disorders | 54 | 2026-01-02 | 2026-03-18 |
| Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia? Virtual online pelvic health program - Vulvodynia (Chronic Vulvar Pain), Vulvar Vestibulitis | Not applicable | Recruiting | Queen's University | 250 | 2025-12-17 | 2026-02-12 |
| Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health Photobiomodulation, Sham photobiomodulation, Multimodal physiotherapy - Vulvodynia, Provoked Vestibulodynia | Not applicable | Recruiting | University of Ottawa | 240 | 2025-03-17 | 2026-05-05 |
| Dry Needling for Provoked Vestibulodynia Real Dry needling, Non penetrating dry needling - Provoked Vestibulodynia | Not applicable | Completed | Université de Sherbrooke | 46 | 2023-02-27 | 2025-02-07 |
| Investigating the Effectiveness of PelvicSense(R) on Pain and Sexual Outcomes in Provoked Vestibulodynia PelvicSense(R) - Provoked Vestibulodynia | Not applicable | Completed | Dr. Caroline Pukall | 15 | 2023-02-25 | 2026-05-06 |
| Is Low Level Laser Therapy (LLLT) Effective for Reducing Pain Experienced by Women With Provoked Vestibulodynia? Low Level Laser Therapy, Sham Low Level Laser Therapy - Provoked Vestibulodynia | Not applicable | Completed | University of Ottawa | 28 | 2021-02-18 | 2023-04-04 |
| Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - a Feasibility Study somatocognitive physiotherapy - Provoked Vestibulodynia | Not applicable | Completed | Oslo Metropolitan University | 10 | 2019-02-01 | 2020-09-30 |
| Internet-based Treatment for Provoked Vestibulodynia Acceptance and commitment therapy - Provoked Vestibulodynia, Vulvodynia, Generalized | Not applicable | Completed | Uppsala University | 60 | 2019-01-20 | 2022-12-27 |
| The Use of Low Intensity Shock Wave Therapy for the Treatment of Provoked Vestibulodynia Disorder (PVD) Shockwave treatment - Provoked Vestibulodynia | Not applicable | Completed | Rambam Health Care Campus | 32 | 2018-06-21 | 2020-09-10 |
| Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Active tDCS or Sham tDCS - Provoked Vestibulodynia | Not applicable | Completed | Université de Sherbrooke | 40 | 2014-11-01 | 2017-05-02 |
| Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Classical Acupuncture, Non-classical acupuncture, Lidocaine - Provoked, Localized Vulvodynia, Provoked Vestibulodynia | Phase 1 | Completed | Oregon College of Oriental Medicine | 19 | 2013-11-01 | 2017-10-06 |
| Outcomes of Delivery in Patients With Dyspareunia Dyspareunia, Pregnancy | Completed | Hadassah Medical Organization | 173 | 2013-01-01 | 2016-10-11 | |
| Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Mindfulness-based Cognitive Therapy, Cognitive Behavioural Therapy - Provoked Vestibulodynia | Not applicable | Completed | University of British Columbia | 130 | 2012-10-01 | 2020-03-10 |
| Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Vulvodynia, Provoked Vestibulodynia | Completed | University of British Columbia | 241 | 2012-03-01 | 2017-06-01 | |
| Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia LOW LEVEL LASER SYSTEM - Provoked Vestibulodynia | Not applicable | Terminated | Hadassah Medical Organization | 34 | 2010-06-01 | 2015-03-24 |
| Integrated Mindfulness for Provoked Vestibulodynia Group Psychoeducational Treatment, Waitlist control - Provoked Vestibulodynia | Not applicable | Completed | University of British Columbia | 97 | 2008-04-01 | 2017-06-01 |
Vulvodynia (11) · Dyspareunia (5) · Pain (3) · Vulvar Vestibulitis (2) · Chronic Pain (1)
Female Urogenital Diseases (12) · Female Urogenital Diseases and Pregnancy Complications (12) · Genital Diseases (12) · Genital Diseases, Female (12) · Urogenital Diseases (12) · Vulvar Diseases (11) · Genital Diseases, Male (5) · Male Urogenital Diseases (5) · Mental Disorders (5) · Sexual Dysfunction, Physiological (5) · Sexual Dysfunctions, Psychological (5) · Neurologic Manifestations (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Vulvitis (2)
Low-Level Light Therapy (2) · Acceptance and Commitment Therapy (1) · Cognitive Behavioral Therapy (1) · Ketotifen (1) · Lidocaine (1) · Mindfulness-Based Cognitive Therapy (1) · Physical Therapy Modalities (1) · salicylhydroxamic acid (1)
University of British Columbia (3) · Université de Sherbrooke (3) · Center for Vulvovaginal Disorders (2) · Hadassah Medical Organization (2) · University of Ottawa (2) · Dr. Caroline Pukall (1) · Oregon College of Oriental Medicine (1) · Oslo Metropolitan University (1) · Queen's University (1) · Rambam Health Care Campus (1) · Uppsala University (1)
Canada (10) · Israel (3) · United States (3) · Norway (1) · Sweden (1)
Lori A Brotto, PhD (3) · Ahinoam Lev-Sagie, MD (2) · Caroline Pukall, PhD (2) · Andrew T Goldstein, MD (1) · Lance McCracken, Professor (1) · Lee E Hullender Rubin, DAOM (1) · Linda McLean (1) · Linda McLean, PhD (1) · Melanie Morin, PhD (1) · Monica Buhrman, PhD (1) · Slawomir Wojniusz, PhD (1) · Stephanie Bernard, PhD (1)
PMID 18209522, PMID 19170850, PMID 27179944, PMID 31592976, PMID 32843320, PMID 33967000, PMID 35321744, PMID 39940084