22 completed, 5 unknown, 3 recruiting, 2 not yet recruiting. 9 Phase 3, 7 Phase 4, 4 Phase 1, 4 Phase 2, 3 Not applicable.
Follow Primary Immunodeficiency: new trials by email Literature Review of Primary Immunodeficiency trials Research Report on Primary Immunodeficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 25BT056: Basket Study of Viral Cytotoxic T Lymphocytes Virus-Specific Cytotoxic T Lymphocytes (vCTLs) - EBV Viremia, CMV Viremia | Early Phase 1 | Not yet recruiting | Children's Hospital of Philadelphia | 35 | 2026-11-01 | 2026-10-22 |
| Quality of Life Among Children With Inborn Error of Immunity Quality of Life Assessment - Primary Immunodeficiency | Not yet recruiting | Sohag University | 50 | 2025-12-01 | 2025-12-03 | |
| An Open-label, Multicenter Study to Assess the Pharmacokinetics (PK), Safety, and Tolerability of Subcutaneous IgPro20 in Immunoglobulin (IG) Treatment-naïve Participants With Primary Immunodeficiency (PID) IgPro - Primary Immunodeficiency | Phase 4 | Completed | CSL Behring | 8 | 2025-07-15 | 2026-07-16 |
| Investigation of the Effects of Pulmonary Rehabilitation in Children With Primary Immunodeficiency Inspiratory muscle training, Upper extremity aerobic exercise training, Lower extremity aerobic exercise training - Primary Immunodeficiency | Not applicable | Unknown | Gazi University | 40 | 2023-11-01 | 2023-12-05 |
| Bronchiectasis Prevalence in Patients With Primary Humoral Immunodefiency in Champagne-Ardenne Region, France Blood test, chest CT scan - Primary Immunodeficiency, Common Variable Immunodeficiency | Not applicable | Completed | CHU de Reims | 46 | 2022-11-28 | 2025-12-18 |
| Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation Collection of samples - Autoimmune Lymphoproliferative Syndrome, Autoimmune Cytopenia | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 325 | 2021-09-07 | 2026-09-18 | |
| Metabolic Profiling of Immune Responses in Immune-mediated Diseases Primary Immunodeficiency, Psoriasis | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 300 | 2021-08-10 | 2026-11-03 | |
| COVID-19 Vaccine in Patients After Allogeneic HCT, CAR-T Therapy and With Primary Immune Deficiency Allogenic Hematopoietic Cell Transplant, CAR-T Therapy | Unknown | Tel-Aviv Sourasky Medical Center | 110 | 2020-12-28 | 2021-01-28 | |
| A Study to Evaluate IGSC 20% Biweekly Dosing in Treatment-Experienced Participants and Loading/Maintenance Dosing in Treatment-Naïve Participants With Primary Immunodeficiency IGSC 20% - Primary Immunodeficiency | Phase 4 | Completed | Grifols Therapeutics LLC | 33 | 2020-11-24 | 2023-09-29 |
| A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Immune Globulin (Human) 10% (Gamunex-C) PEG Process (IVIG-PEG) Compared to Gamunex-C in Participants With Primary Humoral Immunodeficiency Gamunex-C, IVIG-PEG - Primary Immunodeficiency | Phase 3 | Completed | Grifols Therapeutics LLC | 33 | 2020-09-02 | 2023-06-05 |
| Systematic Screening for Primary Immunodeficiencies in Patients Hospitalized for Severe Infections in Intensive Care. Primary Immunodeficiency | Unknown | University Hospital, Montpellier | 90 | 2020-04-01 | 2021-10-12 | |
| Minipooled-IVIG in Primary Immunodeficiency Disease minipooled- Intravenous immunoglobulin(MP-IVIG) - Primary Immunodeficiency | Not applicable | Completed | Assiut University | 15 | 2020-01-01 | 2020-05-12 |
| Study Evaluating IGSC 20% Flexible Dosing in Treatment-Experienced and Treatment-Naive Subjects With Primary Immunodeficiency IGSC 20% daily push versus every 2 weeks pump, IGSC 20% daily push versus once a week pump, IGSC 20% daily push versus 2 times per week pump - Primary Immunodeficiency | Phase 3 | Withdrawn | Grifols Therapeutics LLC | 2019-12-01 | 2020-04-10 | |
| Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies Primary Immunodeficiency | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 3000 | 2019-07-22 | 2026-11-12 | |
| Severe Immune Cytopenia Registry Www.Sic-reg.Org potential biomarkers - Immune Thrombocytopenia, Autoimmune Hemolytic Anemia | Completed | Medical University of Graz | 80 | 2018-03-09 | 2025-11-21 | |
| Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant CD3/CD19 neg allogeneic BMT - Primary Immunodeficiency, PID | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 5 | 2017-12-01 | 2025-07-22 |
| NIAID Centralized Sequencing Protocol Atopy, Primary Immunodeficiency | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 20000 | 2017-07-31 | 2026-11-02 | |
| Safety and Tolerability of Higher Infusion Parameters of IgPro20 (Hizentra) in Subjects With Primary Immunodeficiency (PID) IgPro20 - Primary Immunodeficiency | Phase 4 | Completed | CSL Behring | 49 | 2017-02-01 | 2020-03-25 |
| What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)? Referral to Immunology - Invasive Pneumococcal Disease, Recurrent Isolated, 1, Invasive Pneumococcal Disease, Recurrent Isolated, 2 | Completed | Murdoch Childrens Research Institute | 380 | 2017-01-31 | 2022-07-06 | |
| Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study Rimiducid, rivogenlecleucel - Acute Lymphoblastic Leukemia, Leukemia, Acute Myeloid (AML), Child | Phase 1 / Phase 2 | Terminated | Bellicum Pharmaceuticals | 187 | 2017-01-01 | 2023-09-26 |
Showing 20 of 36. Sign in to see all of them.
Primary Immunodeficiency Diseases (36) · Anemia, Aplastic (3) · Common Variable Immunodeficiency (3) · Myelodysplastic Syndromes (3) · Agammaglobulinemia (2) · Anemia (2) · Anemia, Diamond-Blackfan (2) · Anemia, Sickle Cell (2) · Autoimmune Diseases (2) · Cytopenia (2) · Fanconi Anemia (2) · Hematologic Neoplasms (2) · Hemoglobinopathies (2) · Infections (2) · Leukemia (2)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (36) · Genetic Diseases, Inborn (36) · Immune System Diseases (35) · Immunologic Deficiency Syndromes (35) · Hematologic Diseases (7) · Hemic and Lymphatic Diseases (7) · Lymphatic Diseases (5) · Lymphoproliferative Disorders (5) · Metabolic Diseases (5) · Nutritional and Metabolic Diseases (5) · DNA Repair-Deficiency Disorders (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Anemia, Hemolytic (3) · Blood Coagulation Disorders (3)
gamma-Globulins (6) · Caprylates (3) · Hizentra (3) · AP 1903 reagent (2) · Chromatography (2) · Immunoglobulins, Intravenous (2) · Fluid Therapy (1) · Gadolinium (1) · Gadolinium DTPA (1) · Hematologic Tests (1) · Immunoglobulins (1)
Grifols Therapeutics LLC (6) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Bellicum Pharmaceuticals (2) · CSL Behring (2) · Octapharma (2) · ASIS Corporation (1) · Assiut University (1) · Bio Products Laboratory (1) · CHU de Reims (1) · Children's Hospital of Philadelphia (1) · Chulalongkorn University (1) · GWT-TUD GmbH (1) · Gazi University (1) · IMMUNOe Research Centers (1) · Institut National de la Santé Et de la Recherche Médicale, France (1)
United States (17) · France (6) · Italy (5) · Canada (4) · Australia (3) · Germany (3) · United Kingdom (3) · Turkey (Türkiye) (2) · Austria (1) · Czechia (1) · Egypt (1) · Hungary (1) · Israel (1) · Netherlands (1) · New Zealand (1)
Caitlin Elgarten, MD, MSCE (1) · Caner Aytekin, Assoc. Prof. (1) · David Pittrow, MD (1) · Eric Hachulla, MD, PhD (1) · F P Kroon, PhD, MD (1) · Hanh Nguyen, MD (1) · Helen C Su, M.D. (1) · Ian A Myles, M.D. (1) · Isaac Melamed, MD (1) · Isabelle Quinti, MD (1) · James Moy, MD (1)
PMID 27342758, PMID 31621458, PMID 33025378, PMID 33409867, PMID 35753512, PMID 36818468, PMID 36875114, PMID 37036560, PMID 37215141, PMID 40813536
2016 (2), 2015 (1), U01AI125050 (1)