10 recruiting, 8 completed, 7 not yet recruiting, 6 unknown. 11 Not applicable, 6 Phase 1, 6 Phase 2, 2 Early Phase 1, 2 Phase 3.
Follow Premature Ovarian Insufficiency: new trials by email Literature Review of Premature Ovarian Insufficiency trials Research Report on Premature Ovarian Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress JJGS - Premature Ovarian Insufficiency | Early Phase 1 | Not yet recruiting | Shi Yun | 45 | 2026-09-30 | 2026-09-25 |
| Finerenone for Premature Ovarian Insufficiency (POI) Finerenone, Placebo - Premature Ovarian Insufficiency | Phase 2 | Not yet recruiting | The University of Hong Kong-Shenzhen Hospital | 46 | 2026-09-15 | 2026-09-11 |
| Phase Ⅰ/Ⅱa Trial Evaluating Intravenous hUC-MSCs Injection for Safety, Tolerability and Efficacy in Patients With POI hUC-MSCs Injection (Phase I), hUC-MSCs Injection (Phase IIa), Placebo - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Recruiting | Shenzhen Wingor Biotechnology Co., Ltd. | 59 | 2026-08-03 | 2026-08-20 |
| Genetic Variants in Idiopathic Premature Ovarian Insufficiency Premature Ovarian Insufficiency | Not yet recruiting | Abdurrahman Hamdi İnan | 100 | 2026-06-10 | 2026-05-19 | |
| Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY) Perimenopause, Perimenopause-Related Depression | Enrolling by invitation | Healing Hope International | 12 | 2026-06-01 | 2026-04-06 | |
| A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insufficiency YT023, Control Arm (Conventional Therapy) - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Active not recruiting | International Peace Maternity and Child Health Hospital | 60 | 2026-03-20 | 2026-04-03 |
| Autologous Hair Follicle-Derived Secretome and Platelet-Rich Plasma for Premature Ovarian Insufficiency Autologous Hair Follicle-Derived Secretome Combined With Platelet-Rich Plasma - Premature Ovarian Insufficiency, POI | Phase 2 | Recruiting | Trio Fertility | 15 | 2025-09-11 | 2026-11-04 |
| Efficacy and Safety of Huanjingjian Decoction in Women With Premature Ovarian Insufficiency Huanjingjian decoction, Hormone replacement therapy, Placebo - Premature Ovarian Insufficiency | Not applicable | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 276 | 2025-09-01 | 2025-09-08 |
| Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency Progesterone, Estrogen Patch - Premature Ovarian Insufficiency | Phase 3 | Recruiting | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 185 | 2025-07-17 | 2026-10-29 |
| Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging Vitamin C (Ascorbic Acid), Placebo - Premature Ovarian Insufficiency, Ovarian Reserve Function | Not applicable | Not yet recruiting | Peking University Third Hospital | 354 | 2025-07-02 | 2025-06-26 |
| Microbiome and Premature Ovarian Insufficiency Premature Ovarian Insufficiency, Reproductive Health | Completed | Westlake University | 39 | 2025-05-13 | 2026-06-26 | |
| The Study of Human Chorionic Gonadotropin (HCG) Activating the Dormant Follicles . human chorionic gonadotropin - Premature Ovarian Insufficiency | Phase 1 | Not yet recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 60 | 2025-04-01 | 2025-03-12 |
| Exploratory Clinical Study on the Efficacy and Safety of Lactobacillus Johnsonii in the Treatment of Patients with Premature Ovarian Insufficiency Lactobacillus johnsonii, Placebo - Premature Ovarian Insufficiency | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2025-03-01 | 2025-03-10 |
| Application of Platelet-rich Plasma (PRP) in Reproductive Medicine Platelet-Rich Plasma (PRP) Injections - Premature Ovarian Insufficiency, Intrauterine Adhesion | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 300 | 2024-10-17 | 2025-02-18 |
| Clinical Study on the Safety and Efficacy of Human Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency Climen 21 Tablets, hA-MSCs - Premature Ovarian Insufficiency | Phase 1 / Phase 2 | Recruiting | Yan Hongli | 50 | 2024-10-15 | 2025-08-11 |
| Phase 1 Clinical Trial of CordSTEM-ST umbilical cord-derived mesenchymal stem cell - Premature Ovarian Insufficiency | Phase 1 | Completed | CHABiotech CO., Ltd | 6 | 2024-08-30 | 2025-11-19 |
| Application of Autologous Adipose Stromal Vascular Fraction in the Treatment of Premature Ovarian Insufficiency Conventional IVF, Lower abdominal liposuction and preparation of SVF, Ovarian injection - Premature Ovarian Insufficiency | Not applicable | Recruiting | Rui Yang | 260 | 2024-07-23 | 2024-11-14 |
| The Bone Metabolism Characteristics of Premature Ovarian Insufficiency Testing the serum levels of bone metabolic markers - Premature Ovarian Insufficiency, Bone Diseases, Metabolic | Unknown | Shi Yun | 60 | 2024-04-01 | 2024-06-25 | |
| Treatment of Premature Ovarian Insufficiency Using Bone Marrow Cells autologous bone marrow cells injection - Premature Ovarian Insufficiency | Not applicable | Completed | abdulmajeed hammadi | 10 | 2024-03-01 | 2026-09-14 |
| The Correlation Between Ovarian Function and Serum Biomarkers blood test - Premature Ovarian Insufficiency, Diminished Ovarian Reserve | Recruiting | Shi Yun | 35 | 2023-10-25 | 2024-12-09 |
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Primary Ovarian Insufficiency (35) · Infertility (2) · Autoimmune Diseases (1) · Bone Diseases, Metabolic (1) · Disease (1) · Endocrine System Diseases (1) · Gynatresia (1) · Hot Flashes (1) · Infertility, Female (1) · Multiple Endocrine Neoplasia Type 1 (1) · Patient Satisfaction (1) · Polycystic Ovary Syndrome (1) · Torsades de Pointes (1)
Adnexal Diseases (35) · Female Urogenital Diseases (35) · Female Urogenital Diseases and Pregnancy Complications (35) · Genital Diseases (35) · Genital Diseases, Female (35) · Gonadal Disorders (35) · Ovarian Diseases (35) · Urogenital Diseases (35) · Endocrine System Diseases (34) · Pathological Conditions, Signs and Symptoms (3) · Neoplasms (2) · Pathologic Processes (2) · Arrhythmias, Cardiac (1) · Behavior (1) · Bone Diseases (1)
Injections (3) · Ascorbic Acid (1) · CbsT2 protein, Lactobacillus johnsonii (1) · Chorionic Gonadotropin (1) · Clinical Trials, Phase I as Topic (1) · Electrocardiography (1) · Hematologic Tests (1) · Hormone Replacement Therapy (1) · Progesterone (1) · Rituximab (1) · Saline Solution (1) · Surveys and Questionnaires (1) · finerenone (1)
Shi Yun (4) · Peking University Third Hospital (2) · The Fourth Affiliated Hospital of Zhejiang University School of Medicine (2) · Abdurrahman Hamdi İnan (1) · Angelica Lindén Hirschberg (1) · Assistance Publique - Hôpitaux de Paris (1) · CHABiotech CO., Ltd (1) · Cengiz Gokcek Women's and Children's Hospital (1) · Chinese University of Hong Kong (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Fundación IVI (1) · Healing Hope International (1) · International Peace Maternity and Child Health Hospital (1) · KK Women's and Children's Hospital (1) · Li-jun Ding (1)
China (17) · France (2) · Turkey (Türkiye) (2) · United States (2) · Canada (1) · Germany (1) · Hong Kong (1) · Iraq (1) · Mexico (1) · Singapore (1) · South Korea (1) · Spain (1) · Sweden (1)
Ke Xu, Master (2) · Anne Bachelot, Pr (1) · Catherine M Gordon, M.D. (1) · Dr. Jonatha Leicher, MD: Regenerative Medicine (1) · Fei Yan, Master (1) · Georg Griesing, MD (1) · Guangshu Han, phD (1) · Jing Y Shao, Master (1) · Joe Elie Salem, MD (1) · Michelle Loh (1) · Qin Y Liu, Bachelor (1)
PMID 20424285, PMID 27008889, PMID 27940029, PMID 30415247, PMID 36229897, PMID 36682889, PMID 37441160, PMID 40089715, PMID 40180397, PMID 42334299, PMID 9683349