6 completed, 5 active not recruiting, 4 recruiting, 4 unknown. 5 Not applicable, 3 Phase 2, 2 Early Phase 1.
Follow Premalignant Lesion: new trials by email Literature Review of Premalignant Lesion trials Research Report on Premalignant Lesion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-Based Risk Prediction Model for Upper Digestive Tract Cancer Gastric Cancer (GC), Premalignant Lesion | Not yet recruiting | National Taiwan University Hospital | 10000 | 2026-05-18 | 2026-05-28 | |
| Comparison of TLC (Total Leucocyte Count), Neutrophils and Monocytes in Oral Squamous Cell Carcinoma and Pre-malignant Disorders CBC will be required to assess the level of TLC (Total Leucocyte Count), Neutrophils and Monocytes in patient of oral squamous cell carcinoma and oral pre malignant conditions, using different stains - Oral Squamous Cell Carcinoma (OSCC), Premalignant Lesion | Active not recruiting | Dow University of Health Sciences | 100 | 2026-05-10 | 2026-10-27 | |
| Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions C-REX RectoAid Cath - Rectal Cancer, Sigmoid Cancer | Recruiting | Amsterdam UMC, location VUmc | 165 | 2025-03-25 | 2025-07-09 | |
| Phase II Randomized, Placebo- Controlled Study of Intralesional Nivolumab for High-risk Oral Premalignant Lesions Nivolumab - Premalignant Lesion | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 45 | 2025-02-27 | 2026-08-12 |
| Diagnostic Accuracy of Mobile Phone Imaging Compared to Conventional Clinical Examination for Oral Cancer Screening Diagnosis by mobile phone imaging - Premalignant Lesion, Oral Cancer | Unknown | Cairo University | 174 | 2023-10-01 | 2023-10-03 | |
| Detection of Oral and Throat Cancers Using OralViome Cancer Testing System OralViome Cancer Testing System - Oral Squamous Cell Carcinoma, Oropharynx Squamous Cell Carcinoma | Recruiting | Viome | 475 | 2022-05-27 | 2025-01-29 | |
| Application of Artificial Intelligence on the Diagnosis of Helicobacter Pylori Infection and Premalignant Gastric Lesion Routine endoscopy with artificial intelligence-assisted interpretation - Helicobacter Pylori Infection, Premalignant Lesion | Recruiting | National Taiwan University Hospital | 6000 | 2021-12-24 | 2026-06-24 | |
| Oral Microbioma and Oral Malignant Disease Oral Cancer, Oral Squamous Cell Carcinoma | Unknown | Academisch Ziekenhuis Maastricht | 300 | 2021-12-01 | 2023-03-13 | |
| Diagnostic Accuracy of Salivary Gamma-synuclein in Oral Malignant and Premalignant Lesions Salivary Gamma-synuclein, Incisional biopsy, Conventional visual and tactile examination - Oral Cancer, Oral Lichen Planus | Unknown | Cairo University | 69 | 2021-03-10 | 2021-02-01 | |
| Candonilimab and ATRA Acid for Prevention of Oral Cancer Recurrence in Patients With OPL Candonilimab and ATRA, other treatment or observation - Oral Cavity Cancer, Premalignant Lesion | Phase 2 | Active not recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 22 | 2020-06-30 | 2025-02-24 |
| High-risk Breast Lesions: A Multicenter Retrospective Study Premalignant Lesion | Completed | Ege University | 1345 | 2020-06-10 | 2022-05-02 | |
| The Influence of TAP Block in the Control of Postoperative Pain After Laparotomy for Gynecological Procedures Systemic multimodal analgesia administered intravenously, Transversus abdominis plane block (TAP block), Combined transversus abdominis plane block (TAP block) with systemic multimodal analgesia administered intravenously - Leiomyoma, Pelvic Organ Prolapse | Not applicable | Unknown | General Hospital Pula | 75 | 2019-09-24 | 2019-11-21 |
| Effects of Avmacol® in the Oral Mucosa of Patients Following Curative Treatment for Tobacco-related Head and Neck Cancer Avmacol - Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma (HNSCC) | Not applicable | Completed | University of Pittsburgh | 6 | 2018-07-27 | 2023-04-07 |
| 8-Hydroxy-2-Deoxyguanosine ,Total Antioxidant Capacity in Oral Premalignant and Malignant Lesions Premalignant Lesion | Completed | Fayoum University | 120 | 2018-04-01 | 2019-02-20 | |
| A Clinical and Biological Umbrella Protocol for Smoker or Non-smoker Patients With OPML or HNSCC Samples collection, Psychological and Sociological evaluation, Intensive and sustained smoking cessation program - Premalignant Lesion, Head and Neck Squamous Cell Carcinoma (HNSCC) | Not applicable | Terminated | Centre Leon Berard | 53 | 2018-02-01 | 2020-10-08 |
| Diabetes Prevention Program With or Without Hunger Training in Helping to Lower Breast Cancer Risk in Obese Participants Behavioral, Psychological or Informational Intervention, Questionnaire Administration - Deleterious BRCA1 Gene Mutation, Deleterious BRCA2 Gene Mutation | Not applicable | Active not recruiting | M.D. Anderson Cancer Center | 51 | 2017-12-17 | 2026-10-06 |
| Clinical and Immunohisochemical Evaluation of Chemopreventive Effect of Thymoquinone on Oral Potentially Malignant Lesions. Nigella sativa buccal tablets 10mg, Nigella sativa buccal tablets 5mg, Placebo buccal tablets - Premalignant Lesion | Phase 2 | Completed | Cairo University | 48 | 2017-09-30 | 2021-04-20 |
| Broccoli Sprout Extract in Preventing Recurrence in Patients With Tobacco-Related Head and Neck Squamous Cell Cancer Avmacol® - HNSCC, Head and Neck Cancer | Early Phase 1 | Completed | University of Arizona | 6 | 2017-04-24 | 2021-06-21 |
| Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders Biopsy, Fluorescence Imaging, High-Resolution Microendoscopy - Dysplasia, Lip and Oral Cavity Carcinoma | Early Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 63 | 2016-05-25 | 2026-10-15 |
| Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy Biopsy, Rose Bengal, toluidine blue - Oral Leukoplakia, Oral Lichen Planus | Completed | The Oxford Dental College, Hospital and Research Center, Bangalore, India | 27 | 2015-03-01 | 2018-11-05 |
Showing 20 of 21. Sign in to see all of them.
Mouth Neoplasms (7) · Squamous Cell Carcinoma of Head and Neck (6) · Carcinoma in Situ (2) · Head and Neck Neoplasms (2) · Hyperplasia (2) · Leukoplakia, Oral (2) · Lichen Planus, Oral (2) · Anastomotic Leak (1) · Carcinoma, Intraductal, Noninfiltrating (1) · Carcinoma, Squamous Cell (1) · Chronic Pain (1) · Colorectal Neoplasms (1) · Endometriosis (1) · Erythroplasia (1) · Esophageal Neoplasms (1)
Neoplasms (17) · Neoplasms by Site (14) · Head and Neck Neoplasms (11) · Neoplasms by Histologic Type (9) · Carcinoma (8) · Neoplasms, Glandular and Epithelial (8) · Stomatognathic Diseases (8) · Mouth Diseases (7) · Pathological Conditions, Signs and Symptoms (7) · Carcinoma, Squamous Cell (6) · Pathologic Processes (4) · Lichenoid Eruptions (3) · Pathological Conditions, Anatomical (3) · Precancerous Conditions (3) · Skin Diseases (3)
Biopsy (2) · Optical Imaging (2) · Ethanol (1) · Molecular Diagnostic Techniques (1) · Nigella sativa oil (1) · Nivolumab (1) · Observation (1) · Proflavine (1) · Spectrometry, Fluorescence (1) · Tobacco Products (1) · Tretinoin (1) · thymoquinone (1)
M.D. Anderson Cancer Center (4) · Cairo University (3) · National Taiwan University Hospital (2) · Academisch Ziekenhuis Maastricht (1) · Amsterdam UMC, location VUmc (1) · Centre Leon Berard (1) · Dow University of Health Sciences (1) · Ege University (1) · Fayoum University (1) · General Hospital Pula (1) · Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University (1) · The Oxford Dental College, Hospital and Research Center, Bangalore, India (1) · University of Arizona (1) · University of Pittsburgh (1) · Viome (1)
United States (7) · Egypt (2) · Netherlands (2) · China (1) · Croatia (1) · France (1) · Pakistan (1) · Taiwan (1) · Turkey (Türkiye) (1)
Ann Gillenwater (1) · Ann M Gillenwater (1) · Aysenur Oktay, MD (1) · Basma Abdelalim (1) · Cristina Julian, PhD (1) · Dan P Zandberg, MD (1) · Fatheya Zahran (1) · Julie E. Bauman, MD, MPH (1) · Karen M Basen-Engquist (1) · Mary F Mikhail, TA (1) · Mehak Shamim, FCPS II (1) · Moran Amit, MD, PHD (1) · Ozge Aslan, MD (1) · Tomislav Perkov, MD (1)
PMID 33605440, PMID 38660060, PMID 42623320
P30CA016672 (2), P50CA097190 (1), R21CA215415 (1)