3 completed, 2 active not recruiting, 2 recruiting. 7 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 3, Active not recruiting 2, Recruiting 2 |
| Phase 1 | 3 | Completed 3 |
Follow Preleukemia: new trials by email Literature Review of Preleukemia trials Research Report on Preleukemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial of Orca-T Following Reduced Intensity or Nonmyeloablative Conditioning in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Orca-T - Leukemia, Myeloid, Acute, Myelodysplastic Syndromes | Phase 2 | Recruiting | Orca Biosystems, Inc. | 80 | 2025-12-09 | 2026-07-07 |
| HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis Busulfan, Fludarabine, PBSC Hematopoietic Stem Cell Transplantation (HSCT) - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 313 | 2023-12-08 | 2026-08-17 |
| Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS Metformin - Preleukemia, Myelodysplastic Neoplasm | Phase 2 | Recruiting | Kirsten Grønbæk | 40 | 2021-12-13 | 2024-11-22 |
| HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide Busulfan, Fludarabine, Total-body irradiation - Acute Lymphoblastic Leukemia, Acute Myelogenous Leukemia | Phase 2 | Active not recruiting | Center for International Blood and Marrow Transplant Research | 300 | 2021-09-30 | 2026-03-18 |
| A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies Pelabresib, Ruxolitinib - Myelofibrosis, Leukemia, Myelocytic, Acute | Phase 1 / Phase 2 | Completed | Constellation Pharmaceuticals | 336 | 2014-07-16 | 2026-06-04 |
| A Study of ARRY-520 in Patients With Advanced Myeloid Leukemia ARRY-520, KSP(Eg5) inhibitor; intravenous - Advanced MDS, Acute Myeloid Leukemia | Phase 1 / Phase 2 | Completed | Pfizer | 36 | 2008-03-18 | 2021-02-08 |
| Clofarabine-Melphalan-Alemtuzumab Conditioning in Patients With Advanced Hematologic Malignancies Clofarabine, Melphalan, Campath - Advanced Hematologic Malignancies, Leukemia | Phase 1 / Phase 2 | Completed | University of Chicago | 82 | 2006-03-01 | 2014-02-27 |
Leukemia (5) · Leukemia, Myeloid, Acute (5) · Bone Marrow Diseases (4) · Hematologic Diseases (4) · Myelodysplastic Syndromes (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Precancerous Conditions (4) · Immune System Diseases (3) · Immunoproliferative Disorders (3) · Leukemia, Biphenotypic, Acute (3) · Leukemia, B-Cell (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Lymphoid (2)
Hemic and Lymphatic Diseases (7) · Hematologic Diseases (3) · Leukemia, Myeloid (3) · Neoplasms (3) · Pathological Conditions, Signs and Symptoms (3) · Precancerous Conditions (3) · Chronic Disease (2) · Disease Attributes (2) · Neoplasms by Histologic Type (2) · Pathologic Processes (2) · Anemia (1) · Anemia, Refractory (1) · Blood Coagulation Disorders (1) · Blood Platelet Disorders (1) · Bone Marrow Diseases (1)
Melphalan (3) · Busulfan (2) · Cyclophosphamide (2) · Mesna (2) · Mycophenolic Acid (2) · Patient Reported Outcome Measures (2) · Peripheral Blood Stem Cell Transplantation (2) · Tacrolimus (2) · Whole-Body Irradiation (2) · fludarabine (2) · fludarabine phosphate (2) · Alemtuzumab (1) · Bone Marrow Transplantation (1) · CPI-0610 (1) · Clofarabine (1)
Center for International Blood and Marrow Transplant Research (2) · Constellation Pharmaceuticals (1) · Kirsten Grønbæk (1) · Orca Biosystems, Inc. (1) · Pfizer (1) · University of Chicago (1)
United States (6) · Belgium (1) · Canada (1) · Denmark (1) · France (1) · Germany (1) · Italy (1) · Netherlands (1) · Poland (1) · United Kingdom (1)
Steven Devine, MD (2) · Andrew Artz, MD (1) · Ginna Laport, MD (1)
PMID 22139909, PMID 36881782, PMID 37530627, PMID 38259250, PMID 40523209, PMID 42448319, PMID 42616616
2018 (1)