30 completed. 30 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 30 | Completed 30 |
| Phase 1 | 2 | Completed 2 |
Follow Precancerous Condition: new trials by email Literature Review of Precancerous Condition trials Research Report on Precancerous Condition
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection Multispectral Digital Colposcope (MDC) - Cervical Cancer, Precancerous Condition | Phase 2 | Completed | British Columbia Cancer Agency | 551 | 2012-12-01 | 2019-07-05 |
| Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions vandetanib, placebo, immunohistochemistry staining method - Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma | Phase 2 | Completed | University of Chicago | 20 | 2012-01-01 | 2021-01-14 |
| Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, laboratory biomarker analysis - Anal Cancer, Nonneoplastic Condition | Phase 2 | Completed | AIDS Malignancy Consortium | 149 | 2011-06-28 | 2020-08-11 |
| Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer cetuximab, intensity-modulated radiation therapy (IMRT), Paclitaxel - Head and Neck Cancer, Precancerous Condition | Phase 2 | Completed | Eastern Cooperative Oncology Group | 90 | 2010-08-11 | 2023-06-28 |
| Broccoli Sprout Extract in Treating Women Who Have Had a Mammogram and Breast Biopsy broccoli sprout extract, placebo - Breast Cancer, Precancerous Condition | Phase 2 | Completed | OHSU Knight Cancer Institute | 54 | 2009-08-01 | 2017-04-27 |
| Sulindac in Preventing Melanoma in Healthy Participants Who Are at Increased Risk of Melanoma sulindac, placebo, laboratory biomarker analysis - Precancerous Condition | Phase 2 | Completed | National Cancer Institute (NCI) | 50 | 2009-02-01 | 2017-12-26 |
| Human Papillomavirus Vaccine Therapy in Treating Men With HIV-1 Infection Gardasil - Infection, Precancerous Condition | Phase 2 | Completed | AIDS Malignancy Consortium | 112 | 2007-11-01 | 2023-11-14 |
| Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus cidofovir, DNA methylation analysis, gene expression analysis - Anal Cancer, Precancerous Condition | Phase 2 | Completed | AIDS Malignancy Consortium | 33 | 2007-09-01 | 2015-12-21 |
| Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy darbepoetin alfa, epoetin alfa, fatigue assessment and management - Anemia, Leukemia | Phase 2 | Completed | Mayo Clinic | 239 | 2007-05-01 | 2017-02-10 |
| Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer anti-thymocyte globulin, cyclophosphamide, etoposide - Chronic Myeloproliferative Disorders, Graft Versus Host Disease | Phase 2 | Completed | City of Hope Medical Center | 32 | 2007-05-01 | 2014-09-10 |
| Lovastatin in Treating Patients At High Risk of Melanoma lovastatin, placebo, biopsy - Precancerous Condition, Stage 0 Melanoma | Phase 2 | Completed | National Cancer Institute (NCI) | 80 | 2007-05-01 | 2014-10-31 |
| Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract cetuximab - Head and Neck Cancer, Precancerous Condition | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 35 | 2007-05-01 | 2020-03-12 |
| Aspirin in Preventing Colorectal Cancer in Patients at Increased Risk of Colorectal Cancer acetylsalicylic acid, placebo, laboratory biomarker analysis - Colon Cancer, Precancerous Condition | Phase 2 | Completed | National Cancer Institute (NCI) | 79 | 2007-03-01 | 2017-05-31 |
| Folic Acid Clinical Trial for the Prevention of Cervical Cancer folic acid, placebo - Cervical Cancer, Precancerous Condition | Phase 2 | Completed | University of Alabama at Birmingham | 368 | 2007-03-01 | 2015-10-08 |
| Sulindac in Preventing Lung Cancer in Current or Former Smokers With Bronchial Dysplasia sulindac, placebo - Precancerous Condition, Stage I Non-small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 61 | 2006-08-01 | 2014-05-23 |
| 17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis tanespimycin - Chronic Myeloproliferative Disorders, Leukemia | Phase 2 | Completed | National Institutes of Health Clinical Center (CC) | 37 | 2006-05-01 | 2012-03-15 |
| Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia oligofructose-enriched inulin, sulindac, placebo - Colon Cancer, Precancerous Condition | Phase 2 | Completed | National Cancer Institute (NCI) | 85 | 2006-03-01 | 2017-02-15 |
| Epoetin Alfa in Treating Patients With Anemia Who Are Undergoing Chemotherapy for Cancer epoetin alfa - Anemia, Leukemia | Phase 2 | Completed | Jonsson Comprehensive Cancer Center | 89 | 2005-08-01 | 2012-10-04 |
| Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer therapeutic allogeneic lymphocytes, busulfan, cyclosporine - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 / Phase 2 | Completed | OHSU Knight Cancer Institute | 147 | 2005-06-01 | 2017-09-27 |
| Topical Perillyl Alcohol in Treating Patients With Sun Damaged Skin and Actinic Keratoses perillyl alcohol, placebo - Precancerous Condition | Phase 2 | Completed | University of Arizona | 89 | 2004-05-01 | 2015-04-01 |
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Precancerous Conditions (30) · Uterine Cervical Dysplasia (6) · Uterine Cervical Neoplasms (6) · Burkitt Lymphoma (5) · Leukemia (5) · Leukemia, Lymphocytic, Chronic, B-Cell (5) · Lymphoma (5) · Lymphoma, B-Cell, Marginal Zone (5) · Lymphoma, Follicular (5) · Lymphoma, Large B-Cell, Diffuse (5) · Lymphoma, Large-Cell, Immunoblastic (5) · Lymphoma, Mantle-Cell (5) · Lymphoma, Non-Hodgkin (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Hodgkin Disease (4)
Neoplasms (30) · Neoplasms by Site (22) · Neoplasms by Histologic Type (11) · Pathological Conditions, Signs and Symptoms (11) · Genital Diseases (9) · Urogenital Diseases (9) · DNA Virus Infections (8) · Disease Attributes (8) · Pathologic Processes (8) · Tumor Virus Infections (8) · Virus Diseases (8) · Female Urogenital Diseases (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Genital Diseases, Female (7) · Infections (7)
Biopsy (3) · Methotrexate (3) · Sulindac (3) · Cetuximab (2) · Epoetin Alfa (2) · Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 (2) · Peripheral Blood Stem Cell Transplantation (2) · Whole-Body Irradiation (2) · fludarabine phosphate (2) · 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (1) · Albumin-Bound Paclitaxel (1) · Aminolevulinic Acid (1) · Antilymphocyte Serum (1) · Aspirin (1) · Atorvastatin (1)
National Cancer Institute (NCI) (5) · AIDS Malignancy Consortium (3) · British Columbia Cancer Agency (2) · OHSU Knight Cancer Institute (2) · Roswell Park Cancer Institute (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Albert Einstein College of Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Children's Hospital of Philadelphia (1) · City of Hope Medical Center (1) · Eastern Cooperative Oncology Group (1) · Fox Chase Cancer Center (1) · Jonsson Comprehensive Cancer Center (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1)
United States (29) · Canada (3) · Puerto Rico (1)
Joel Palefsky, MD (3) · Michele Follen, MD, PhD (2) · Antonio T. Fojo, MD, PhD (1) · Bobbie S. Gostout, MD (1) · Carolyn D. Runowicz, MD (1) · Chandrika J. Piyathilake, PhD, MPH (1) · Charles L. Loprinzi, M.D. (1) · Cornelia L. Trimble, MD (1) · Elizabeth Stier, MD (1) · Hector R. Nava, MD, FACS (1) · Hemant Roy (1) · Jackilen Shannon, PhD (1) · James Jett (1) · Jean B. Belasco, MD (1)
PMID 17586030, PMID 19118066, PMID 19170225, PMID 20812850, PMID 21636546, PMID 21907959, PMID 23032420, PMID 23261228, PMID 25057165, PMID 26329135, PMID 26503631, PMID 26511489, PMID 28029303, PMID 30658128, PMID 34907980
P30CA015083 (3), U01CA121947 (3), N01CN35000 (2), P30CA006973 (2), P30CA023074 (2), N01CN35157 (1), N01CN35158 (1), N01CN35160 (1), P01CA027502 (1), P01CA082710 (1), P30CA016058 (1), P30CA016672 (1), P30CA033572 (1), P30CA069533 (1), P50CA096784 (1)