100 completed, 14 terminated, 13 unknown, 5 withdrawn. 39 Phase 2, 27 Phase 1, 21 Not applicable, 19 Phase 3, 1 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Noninvasive Early Diagnosis of Colorectal Cancer Using Odor-Targeted Capture, Point-of-Care Testing, and Intelligent Analysis CRC, Precancerous Condition | Not yet recruiting | Beijing University of Chinese Medicine | 453 | 2026-06-10 | 2026-06-02 | |
| Hepatobiliary Tumors Tissue Samples Acquisition Gene expression analysis, Genomic analysis, Protein expression analysis - Hepatocellular Carcinoma, Cholangiocarcinoma | Unknown | Peking Union Medical College Hospital | 450 | 2020-10-11 | 2023-07-07 | |
| Pilot Study In Vivo Confocal Microscopy Probe for Cervical Precancer In Vivo Confocal Microscopy Probe - Precancerous Condition, Cervical Cancer | Terminated | British Columbia Cancer Agency | 60 | 2019-09-01 | 2024-03-18 | |
| Factors Affecting Patient Participation in AIDS Malignancy Clinical Trials Consortium Clinical Trials questionnaire administration - HIV Infection, Malignant Neoplasm | Completed | AIDS Malignancy Consortium | 82 | 2013-09-01 | 2016-08-18 | |
| Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection Multispectral Digital Colposcope (MDC) - Cervical Cancer, Precancerous Condition | Phase 2 | Completed | British Columbia Cancer Agency | 551 | 2012-12-01 | 2019-07-05 |
| Natural History of Lung Nodules Seen on CT Scans From Participants at High-Risk of Developing Lung Cancer medical chart review, computed tomography, computer-aided detection/diagnosis - Lung Cancer, Precancerous Condition | Completed | M.D. Anderson Cancer Center | 320 | 2012-02-01 | 2013-01-25 | |
| Vandetanib in Preventing Head and Neck Cancer in Patients With Precancerous Head and Neck Lesions vandetanib, placebo, immunohistochemistry staining method - Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma | Phase 2 | Completed | University of Chicago | 20 | 2012-01-01 | 2021-01-14 |
| Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, laboratory biomarker analysis - Anal Cancer, Nonneoplastic Condition | Phase 2 | Completed | AIDS Malignancy Consortium | 149 | 2011-06-28 | 2020-08-11 |
| Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer cetuximab, cisplatin, IMRT - Head and Neck Cancer, Precancerous Condition | Phase 3 | Completed | Radiation Therapy Oncology Group | 987 | 2011-06-01 | 2026-07-20 |
| Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia clinical observation, infrared photocoagulation therapy - Anal Cancer, Neoplasm of Uncertain Malignant Potential | Phase 3 | Completed | AIDS Malignancy Consortium | 120 | 2011-04-01 | 2020-08-04 |
| Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia histological technique, laboratory biomarker analysis, colposcopic biopsy - Cervical Cancer, Precancerous Condition | Not applicable | Completed | British Columbia Cancer Agency | 114 | 2010-12-01 | 2017-02-01 |
| Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An Abnormal Pap Smear Cervical Cancer, Precancerous Condition | Withdrawn | British Columbia Cancer Agency | 2010-12-01 | 2014-07-21 | ||
| Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer cetuximab, intensity-modulated radiation therapy (IMRT), Paclitaxel - Head and Neck Cancer, Precancerous Condition | Phase 2 | Completed | Eastern Cooperative Oncology Group | 90 | 2010-08-11 | 2023-06-28 |
| Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery rosuvastatin, placebo - Colorectal Cancer, Precancerous Condition | Phase 3 | Terminated | NSABP Foundation Inc | 406 | 2010-03-01 | 2023-08-16 |
| Aspirin Mouthwash in Treating Patients With Oral Leukoplakia acetylsalicylic acid, gene expression analysis, protein expression analysis - Precancerous Condition | Phase 1 | Completed | Institute of Head and Neck Studies and Education, United Kingdom | 40 | 2010-02-01 | 2013-08-12 |
| Green Tea Extract in Treating Patients With Monoclonal Gammopathy of Undetermined Significance and/or Smoldering Multiple Myeloma defined green tea catechin extract, gene expression analysis, protein analysis - Multiple Myeloma and Plasma Cell Neoplasm, Precancerous Condition | Phase 2 | Terminated | Barbara Ann Karmanos Cancer Institute | 8 | 2009-11-01 | 2015-03-27 |
| Broccoli Sprout Extract in Treating Women Who Have Had a Mammogram and Breast Biopsy broccoli sprout extract, placebo - Breast Cancer, Precancerous Condition | Phase 2 | Completed | OHSU Knight Cancer Institute | 54 | 2009-08-01 | 2017-04-27 |
| Vaccine Therapy in Preventing HPV in HIV-Positive Women in India quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, DNA analysis, polymerase chain reaction - Cervical Cancer, Nonneoplastic Condition | Phase 1 | Completed | AIDS Malignancy Consortium | 150 | 2009-08-01 | 2024-03-19 |
| Human Papilloma Virus Infection in HIV-Positive Indian Men Who Have Sex With Men DNA analysis, polymerase chain reaction, fluorescence activated cell sorting - Nonneoplastic Condition, Precancerous Condition | Completed | AIDS Malignancy Consortium | 302 | 2009-07-01 | 2015-10-05 | |
| Self-Sampling in Women Who Do Not Undergo Routine Cervical Screening compliance monitoring, cervical Papanicolaou test, educational intervention - Health Status Unknown, Precancerous Condition | Completed | Barts and the London School of Medicine and Dentistry | 3000 | 2009-06-01 | 2013-08-07 |
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Precancerous Conditions (136) · Lymphoma (28) · Multiple Myeloma (27) · Leukemia (26) · Monoclonal Gammopathy of Undetermined Significance (26) · Neoplasms, Plasma Cell (26) · Uterine Cervical Dysplasia (25) · Uterine Cervical Neoplasms (25) · Burkitt Lymphoma (24) · Leukemia, Lymphocytic, Chronic, B-Cell (24) · Lymphoma, B-Cell, Marginal Zone (24) · Lymphoma, Follicular (24) · Lymphoma, Large B-Cell, Diffuse (24) · Lymphoma, Large-Cell, Immunoblastic (24) · Lymphoma, Mantle-Cell (24)
Neoplasms (134) · Neoplasms by Site (99) · Neoplasms by Histologic Type (59) · Pathological Conditions, Signs and Symptoms (51) · Genital Diseases (42) · Pathologic Processes (42) · Urogenital Diseases (42) · Immune System Diseases (40) · Virus Diseases (40) · DNA Virus Infections (39) · Disease Attributes (39) · Tumor Virus Infections (39) · Infections (37) · Hemic and Lymphatic Diseases (33) · Immunoproliferative Disorders (33)
Biopsy (11) · Polymerase Chain Reaction (7) · Gene Expression Profiling (6) · Immunohistochemistry (5) · Microarray Analysis (5) · Cetuximab (4) · Colposcopy (4) · Epoetin Alfa (4) · Sulindac (4) · fludarabine phosphate (4) · Aspirin (3) · Busulfan (3) · Celecoxib (3) · Comparative Genomic Hybridization (3) · Cyclophosphamide (3)
British Columbia Cancer Agency (11) · AIDS Malignancy Consortium (9) · National Cancer Institute (NCI) (9) · M.D. Anderson Cancer Center (6) · Alliance for Clinical Trials in Oncology (5) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (5) · Barbara Ann Karmanos Cancer Institute (4) · Case Comprehensive Cancer Center (4) · Mayo Clinic (4) · OHSU Knight Cancer Institute (4) · Roswell Park Cancer Institute (4) · Northwestern University (3) · University of Colorado, Denver (3) · Wake Forest University Health Sciences (3) · Barts and the London School of Medicine and Dentistry (2)
United States (105) · Canada (15) · United Kingdom (7) · France (5) · Germany (3) · Italy (3) · China (2) · Australia (1) · Belgium (1) · Costa Rica (1) · India (1) · Israel (1) · Puerto Rico (1) · Senegal (1) · Slovakia (1)
Joel Palefsky, MD (5) · Stephen Lam, MD (4) · Jackilen Shannon, PhD (3) · Michele Follen, MD, PhD (3) · Cornelia L. Trimble, MD (2) · Elizabeth Stier, MD (2) · M. Peter Lance, MD (2) · Maura Gillison, MD, PhD (2) · Sylvia Lam (2) · Thomas G Ehlen, M.D. (2) · York E. Miller, MD (2) · Alex A. Adjei, MD, PhD (1) · Andy M. Trotti, MD (1) · Anne Szarewski, MD (1) · Antonio T. Fojo, MD, PhD (1)
PMID 25057165, PMID 16505427, PMID 17119113, PMID 17586030, PMID 17699008, PMID 18378608, PMID 18386103, PMID 18809146, PMID 18948732, PMID 19118066, PMID 19170225, PMID 20197322, PMID 20234350, PMID 20538001, PMID 20812850, PMID 21115882, PMID 21636546, PMID 21865087, PMID 21907959, PMID 22277551, PMID 22850119, PMID 22964741, PMID 23032420, PMID 23060037, PMID 23261228, PMID 23358983, PMID 23432617, PMID 23595039, PMID 23834901, PMID 23873171, PMID 24014882, PMID 24144643, PMID 24386300, PMID 24477000, PMID 24958910, PMID 25018097, PMID 25139208, PMID 25672894, PMID 25796338, PMID 26071347, PMID 26138736, PMID 26329135, PMID 26346155, PMID 26420854, PMID 26467666, PMID 26468228, PMID 26503631, PMID 26511489, PMID 26892991, PMID 27519183
U01CA121947 (8), P30CA015083 (5), P30CA068485 (5), P01CA082710 (4), P30CA006973 (4), P30CA022453 (4), P30CA043703 (4), P30CA016672 (3), P30CA023074 (3), P30CA069533 (3), N01CN35000 (2), P30CA033572 (2), P30CA060553 (2), P50CA058187 (2), R01CA103830 (2)