20 completed, 5 unknown, 2 terminated. 27 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 27 | Completed 20, Unknown 5, Terminated 2 |
| Phase 2 | 4 | Completed 2, Unknown 2 |
Follow Precancerous Condition: new trials by email Literature Review of Precancerous Condition trials Research Report on Precancerous Condition
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aspirin Mouthwash in Treating Patients With Oral Leukoplakia acetylsalicylic acid, gene expression analysis, protein expression analysis - Precancerous Condition | Phase 1 | Completed | Institute of Head and Neck Studies and Education, United Kingdom | 40 | 2010-02-01 | 2013-08-12 |
| Vaccine Therapy in Preventing HPV in HIV-Positive Women in India quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine, DNA analysis, polymerase chain reaction - Cervical Cancer, Nonneoplastic Condition | Phase 1 | Completed | AIDS Malignancy Consortium | 150 | 2009-08-01 | 2024-03-19 |
| Tethered Capsule Endoscope in Screening Participants for Barrett Esophagus questionnaire administration, comparison of screening methods, diagnostic endoscopic procedure - Esophageal Cancer, Precancerous Condition | Phase 1 / Phase 2 | Unknown | US Department of Veterans Affairs | 50 | 2009-05-01 | 2014-01-10 |
| Transoral Robotic Surgery or Standard Surgery in Treating Patients With Benign or Malignant Tumors of the Larynx and Pharynx assessment of therapy complications, diagnostic endoscopic surgery, quality-of-life assessment - Head and Neck Cancer, Perioperative/Postoperative Complications | Phase 1 | Completed | Barbara Ann Karmanos Cancer Institute | 6 | 2009-05-01 | 2014-05-09 |
| Photodynamic Therapy in Treating Patients With Premalignant or Early Stage Head and Neck Tumors aminolevulinic acid hydrochloride - Head and Neck Cancer, Precancerous Condition | Phase 1 | Completed | Abramson Cancer Center at Penn Medicine | 35 | 2009-01-01 | 2019-04-23 |
| Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia TA-HPV, pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine, imiquimod - Cervical Cancer, Precancerous Condition | Phase 1 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 75 | 2008-11-01 | 2023-08-31 |
| Cidofovir in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer Who Are Receiving Chemotherapy and Radiation Therapy carboplatin, cidofovir, protein expression analysis - Cervical Cancer, Precancerous Condition | Phase 1 | Unknown | Gustave Roussy, Cancer Campus, Grand Paris | 24 | 2008-04-01 | 2010-01-28 |
| Erlotinib in Treating Patients With Barrett Esophagus erlotinib hydrochloride, laboratory biomarker analysis, biopsy - Esophageal Cancer, Precancerous Condition | Phase 1 | Unknown | Kansas City Veteran Affairs Medical Center | 25 | 2007-07-01 | 2013-09-17 |
| Studying Genes in Blood and Lung Fluid Samples From Patients With Chronic Obstructive Pulmonary Disease With or Without a Previous Diagnosis of Lung Cancer or With Asthma Treated With Budesonide and Formoterol budesonide/formoterol fumarate dihydrate inhalation aerosol, DNA methylation analysis, comparative genomic hybridization - Lung Cancer, Precancerous Condition | Phase 1 | Completed | British Columbia Cancer Agency | 30 | 2007-01-01 | 2012-03-09 |
| Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples microarray analysis, flow cytometry, biopsy - Cervical Cancer, Precancerous Condition | Phase 1 | Terminated | British Columbia Cancer Agency | 50 | 2006-09-01 | 2017-02-01 |
| Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer therapeutic allogeneic lymphocytes, busulfan, cyclosporine - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 / Phase 2 | Completed | OHSU Knight Cancer Institute | 147 | 2005-06-01 | 2017-09-27 |
| Zoledronate in Treating Patients With Cervical Intraepithelial Neoplasia 2/3 or 3 Zoledronate, Placebo (Saline) - Cervical Cancer, Precancerous Condition | Phase 1 | Terminated | University of California, San Francisco | 12 | 2005-04-01 | 2017-11-24 |
| Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides silicon phthalocyanine 4 - Lymphoma, Non-melanomatous Skin Cancer | Phase 1 | Completed | Case Comprehensive Cancer Center | 43 | 2004-09-01 | 2019-01-22 |
| Vaccine Therapy in Preventing Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine - Cervical Cancer, Precancerous Condition | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 16 | 2003-11-01 | 2018-07-20 |
| Infrared Coagulation in Preventing Anal Cancer in Patients With HIV Who Have Anal Neoplasia infrared photocoagulation therapy, Infrared Coagulator - Anal Cancer, Precancerous Condition | Phase 1 | Completed | AIDS Malignancy Consortium | 18 | 2003-09-01 | 2014-09-17 |
| Inositol in Preventing Lung Cancer in Patients With Bronchial Epithelial Dysplasia Who Are Current or Former Smokers inositol - Lung Cancer, Precancerous Condition | Phase 1 | Completed | British Columbia Cancer Agency | 2003-05-01 | 2010-02-02 | |
| Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas pirfenidone - Neurofibromatosis Type 1, Precancerous Condition | Phase 1 | Completed | National Cancer Institute (NCI) | 2002-12-01 | 2015-04-30 | |
| Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis celecoxib, placebo - Colorectal Cancer, Precancerous Condition | Phase 1 | Completed | M.D. Anderson Cancer Center | 22 | 2002-11-21 | 2018-11-07 |
| Pyroxamide in Treating Patients With Advanced Cancer pyroxamide - Chronic Myeloproliferative Disorders, Leukemia | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 2002-04-01 | 2013-06-05 | |
| Cetuximab in Treating Patients With Ménétrier Disease at High Risk of Developing Stomach Cancer Cetuximab - Gastric Cancer, Precancerous Condition | Phase 1 | Completed | Vanderbilt University | 9 | 2001-04-01 | 2017-01-10 |
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Precancerous Conditions (27) · Lymphoma (9) · Burkitt Lymphoma (8) · Leukemia (8) · Leukemia, Lymphocytic, Chronic, B-Cell (8) · Lymphoma, B-Cell, Marginal Zone (8) · Lymphoma, Follicular (8) · Lymphoma, Large B-Cell, Diffuse (8) · Lymphoma, Large-Cell, Immunoblastic (8) · Lymphoma, Mantle-Cell (8) · Lymphoma, Non-Hodgkin (8) · Monoclonal Gammopathy of Undetermined Significance (8) · Multiple Myeloma (8) · Neoplasms, Plasma Cell (8) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (8)
Neoplasms (27) · Neoplasms by Site (23) · Neoplasms by Histologic Type (13) · Pathological Conditions, Signs and Symptoms (13) · Immune System Diseases (11) · Pathologic Processes (11) · DNA Virus Infections (10) · Disease Attributes (10) · Hemic and Lymphatic Diseases (10) · Immunoproliferative Disorders (10) · Infections (10) · Lymphoproliferative Disorders (10) · Tumor Virus Infections (10) · Virus Diseases (10) · Hematologic Diseases (9)
Biopsy (3) · Carboplatin (2) · Microarray Analysis (2) · Amifostine (1) · Aminolevulinic Acid (1) · Aspirin (1) · Bortezomib (1) · Brachytherapy (1) · Bronchoalveolar Lavage (1) · Bronchoscopy (1) · Budesonide (1) · Busulfan (1) · Celecoxib (1) · Cetuximab (1) · Cidofovir (1)
British Columbia Cancer Agency (3) · AIDS Malignancy Consortium (2) · National Cancer Institute (NCI) (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Abramson Cancer Center at Penn Medicine (1) · Barbara Ann Karmanos Cancer Institute (1) · Boston Medical Center (1) · California Cancer Consortium (1) · Case Comprehensive Cancer Center (1) · Gustave Roussy, Cancer Campus, Grand Paris (1) · Institute of Head and Neck Studies and Education, United Kingdom (1) · Kansas City Veteran Affairs Medical Center (1) · LifeTime Pharmaceuticals (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1)
United States (21) · Canada (3) · France (2) · Germany (1) · India (1) · Italy (1) · United Kingdom (1)
Cornelia L. Trimble, MD (2) · Stephen Lam, MD (2) · Alex A. Adjei, MD, PhD (1) · Brigitte C. Widemann, MD (1) · Douglas V. Faller, MD, PhD (1) · Elizabeth Stier, MD (1) · Elma Baron, MD (1) · Eric Deutsch, MD (1) · George Thomas Budd, MD (1) · Hisham Mehanna, MD (1) · Ho-Sheng Lin, MD (1) · Howard S. Hochster, MD (1) · Jason A. Dominitz, MD (1) · Jeffrey S. Weber, MD, PhD (1) · Joaquina C. Baranda, MD (1)
PMID 17119113, PMID 19118066, PMID 20234350, PMID 24386300, PMID 24477000, PMID 26420854, PMID 33468698, PMID 9628848
P30CA006973 (1), P30CA015083 (1), P30CA016058 (1), P30CA016087 (1), P30CA022453 (1), P30CA043703 (1), P30CA068485 (1), P50CA098252 (1), R01CA103830 (1), R21CA105696 (1), R21CA123876 (1), U01CA069912 (1), U01CA121947 (1)