366 completed, 65 terminated, 31 unknown, 21 withdrawn. 201 Phase 1, 196 Phase 2, 50 Phase 3, 47 Not applicable, 3 Early Phase 1.
Follow Lymphoma, Large-Cell, Immunoblastic: new trials by email Literature Review of Lymphoma, Large-Cell, Immunoblastic trials Research Report on Lymphoma, Large-Cell, Immunoblastic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma rituximab, lenalidomide, romidepsin - B-cell Adult Acute Lymphoblastic Leukemia, Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Phase 1 / Phase 2 | Withdrawn | Mayo Clinic | 2016-10-01 | 2016-08-11 | |
| Dasatinib for Modulating Immune System After Autologous Stem Cell Transplants for Multiple Myeloma, Non-Hodgkin, or Hodgkin Lymphoma Dasatinib - Non-Hodgkin's Lymphoma, Multiple | Phase 1 | Terminated | Barbara Ann Karmanos Cancer Institute | 8 | 2015-02-12 | 2020-03-16 |
| Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma carmustine, cytarabine, melphalan - Adult Nasal Type Extranodal NK/T-cell Lymphoma, AIDS-related Diffuse Large Cell Lymphoma | Not applicable | Withdrawn | Fred Hutchinson Cancer Center | 2015-02-01 | 2015-05-07 | |
| CPI-613, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma 6,8-bis(benzylthio)octanoic acid, bendamustine hydrochloride, rituximab - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Chronic Lymphocytic Leukemia | Phase 1 | Terminated | Wake Forest University Health Sciences | 1 | 2014-12-01 | 2018-07-02 |
| Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Ibrutinib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Chronic Lymphocytic Leukemia | Phase 1 | Terminated | National Cancer Institute (NCI) | 72 | 2014-09-01 | 2015-08-20 |
| Lenalidomide and Combination Chemotherapy (DA-EPOCH-R) in Treating Patients With MYC-Associated B-Cell Lymphomas lenalidomide, etoposide, prednisone - Adult Grade III Lymphomatoid Granulomatosis, B-cell Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | Completed | University of Chicago | 55 | 2014-07-29 | 2026-03-11 |
| Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes Cyclophosphamide or Bendamustine, Dose Level -1, Dose Level 1 - Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Unknown | Jichi Medical University | 18 | 2014-05-01 | 2014-11-06 |
| Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant busulfan, etoposide, cyclophosphamide - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Early Phase 1 | Completed | Case Comprehensive Cancer Center | 33 | 2014-03-01 | 2015-08-13 |
| Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies cyclophosphamide, fludarabine phosphate, mycophenolate mofetil - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 2 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2014-01-01 | 2016-07-14 | |
| DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma DT2219ARL - Leukemia, Lymphoma | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 25 | 2013-12-02 | 2017-12-02 |
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma autologous CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T cells, autologous hematopoietic stem cell transplantation, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Cutaneous B-cell Non-Hodgkin Lymphoma | Phase 1 | Active not recruiting | City of Hope Medical Center | 30 | 2013-10-08 | 2026-06-25 |
| Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies vorinostat, tacrolimus, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2013-06-01 | 2018-07-24 |
| Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies therapeutic allogeneic lymphocytes, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 2 | Completed | University of Chicago | 77 | 2013-04-04 | 2019-08-07 |
| Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas brentuximab vedotin, rituximab, laboratory biomarker analysis - Adult Grade III Lymphomatoid Granulomatosis, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Terminated | Northwestern University | 20 | 2013-03-05 | 2021-09-01 |
| Ipilimumab and Local Radiation for Selected Solid Tumors Ipilimumab, Radiation therapy - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Terminated | Stanford University | 3 | 2013-02-01 | 2024-01-24 |
| Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem Cell Transplant management of therapy complications, musculoskeletal complications management/prevention - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Not applicable | Withdrawn | Roswell Park Cancer Institute | 2012-05-01 | 2012-07-09 | |
| Lenalidomide With or Without Rituximab in Treating Patients With Progressive or Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Prolymphocytic Leukemia, or Non-Hodgkin Lymphoma Previously Treated With Donor Stem Cell Transplant lenalidomide, rituximab, pharmacological study - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 2 | Terminated | Fred Hutchinson Cancer Center | 3 | 2012-05-01 | 2017-07-27 |
| Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic Malignancies Dasatinib, laboratory biomarker analysis - Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma | Phase 1 | Terminated | Barbara Ann Karmanos Cancer Institute | 5 | 2012-05-01 | 2020-12-17 |
| Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Alisertib, Laboratory Biomarker Analysis, Pharmacological Study - Adult B Acute Lymphoblastic Leukemia, Adult T Acute Lymphoblastic Leukemia | Phase 1 | Completed | National Cancer Institute (NCI) | 34 | 2012-04-16 | 2018-04-11 |
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Lymphoma, Large B-Cell, Diffuse (480) · Lymphoma, Non-Hodgkin (467) · Lymphoma, Follicular (464) · Burkitt Lymphoma (445) · Lymphoma, Mantle-Cell (437) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (426) · Leukemia, Lymphocytic, Chronic, B-Cell (418) · Lymphoma, B-Cell, Marginal Zone (409) · Lymphoma (353) · Hodgkin Disease (318) · Lymphoma, T-Cell, Cutaneous (246) · Multiple Myeloma (222) · Mycosis Fungoides (216) · Sezary Syndrome (216)
Hemic and Lymphatic Diseases (490) · Immunoproliferative Disorders (490) · Lymphatic Diseases (490) · Immune System Diseases (489) · Neoplasms by Histologic Type (489) · Lymphoma, B-Cell (488) · Lymphoproliferative Disorders (461) · Hematologic Diseases (452) · Leukemia, Lymphoid (449) · DNA Virus Infections (445) · Herpesviridae Infections (445) · Neoplasms (445) · Tumor Virus Infections (445) · Virus Diseases (444) · Epstein-Barr Virus Infections (443)
Cyclophosphamide (116) · Peripheral Blood Stem Cell Transplantation (96) · Filgrastim (73) · Etoposide (68) · fludarabine phosphate (61) · Radiotherapy (58) · Rituximab (57) · Cyclosporine (49) · Mycophenolic Acid (46) · Busulfan (44) · Melphalan (40) · Cytarabine (37) · Whole-Body Irradiation (36) · Antilymphocyte Serum (35) · Tacrolimus (34)
National Cancer Institute (NCI) (58) · Fred Hutchinson Cancer Center (48) · Case Comprehensive Cancer Center (23) · Memorial Sloan Kettering Cancer Center (21) · City of Hope Medical Center (19) · Northwestern University (15) · Masonic Cancer Center, University of Minnesota (14) · National Institutes of Health Clinical Center (CC) (13) · Roswell Park Cancer Institute (13) · Alliance for Clinical Trials in Oncology (12) · Barbara Ann Karmanos Cancer Institute (12) · Jonsson Comprehensive Cancer Center (12) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (12) · Mayo Clinic (10) · University of Nebraska (10)
United States (431) · Italy (19) · Canada (17) · Germany (16) · France (11) · Switzerland (11) · United Kingdom (11) · Belgium (6) · Israel (5) · Czechia (4) · Slovakia (4) · Sweden (4) · Turkey (Türkiye) (4) · Australia (3) · Austria (3)
Ajay Gopal (6) · Christos E. Emmanouilides, MD (5) · David Maloney (5) · Julie M Vose, MD (5) · Leo I. Gordon, MD (5) · Brenda Sandmaier (4) · Claudio G. Brunstein, MD, PhD (4) · Craig Moskowitz, MD (4) · Jane N. Winter, MD (4) · Philip L. McCarthy, MD (4) · Shivaani Kummar, MD (4) · Thomas C. Shea, MD (4) · Todd M. Zimmerman, MD (4) · Asad Bashey, MD, PhD (3) · Auayporn P. Nademanee, MD (3)
PMID 32499241, PMID 19949018, PMID 20028764, PMID 22002018, PMID 34515338, PMID 10552943, PMID 10632319, PMID 10764422, PMID 11410496, PMID 11756154, PMID 12121233, PMID 12171484, PMID 12525530, PMID 1403051, PMID 14508361, PMID 14630682, PMID 14630685, PMID 14739217, PMID 14767498, PMID 15013589, PMID 15107815, PMID 15386331, PMID 15459300, PMID 15466923, PMID 15570084, PMID 16135477, PMID 16148284, PMID 16449523, PMID 16710026, PMID 16754935, PMID 16888080, PMID 17119113, PMID 17312328, PMID 17312330, PMID 17397698, PMID 17889355, PMID 17910637, PMID 17947483, PMID 18065407, PMID 18256325, PMID 18293016, PMID 18327587, PMID 18463792, PMID 18470481, PMID 18569634, PMID 18645482, PMID 18698002, PMID 18769450, PMID 18794865, PMID 18974373
P30CA043703 (18), P30CA033572 (17), P30CA015704 (15), P30CA022453 (11), P30CA006973 (10), P30CA015083 (8), U10CA032102 (8), P30CA036727 (7), U10CA031946 (7), P01CA015396 (6), P30CA068485 (6), P30CA072720 (6), P01CA018029 (5), P30CA016672 (5), U01CA062487 (5)