10 completed. 10 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 10 |
| Phase 2 | 1 | Completed 1 |
Follow Polymyalgia Rheumatica: new trials by email Literature Review of Polymyalgia Rheumatica trials Research Report on Polymyalgia Rheumatica
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Induction and Tapering Therapy With Tofacitinib and Glucocorticoid in Patients With Polymyalgia Rheumatica Prednisone+Tofacitinib, Prednisone - Polymyalgia Rheumatica | Phase 3 | Completed | Zhejiang University | 104 | 2024-01-20 | 2026-09-08 |
| Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR) Secukinumab 300 mg, Secukinumab 150 mg, Placebo to secukinumab - Polymyalgia Rheumatica | Phase 3 | Completed | Novartis Pharmaceuticals | 381 | 2023-03-22 | 2026-06-22 |
| Rituximab Effect on Decreasing glUcoCorticoid Exposition in PolyMyalgia Rheumatica Patients Recently Diagnosed Rituximab, Placebo - Polymyalgia Rheumatica | Phase 3 | Completed | Sint Maartenskliniek | 114 | 2023-02-01 | 2026-02-03 |
| Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remission Secukinumab 300 mg, s.c., Placebo to match Secukinumab, s.c. - Giant Cell Arteritis | Phase 3 | Completed | Novartis Pharmaceuticals | 151 | 2022-09-29 | 2026-02-27 |
| Abatacept in earLy Onset Polymyalgia Rheumatica: Study ALORS Abatacept, Placebos - Polymyalgia Rheumatica | Phase 3 | Completed | University Hospital, Brest | 34 | 2018-12-13 | 2026-06-08 |
| A Study to Evaluate the Efficacy of Tocilizumab as a Remission-Induction and Glucocorticoid-Sparing Regimen in Subjects With New-Onset Polymyalgia Rheumatica (PMR- SPARE) Tocilizumab Prefilled Syringe [Actemra], Placebos, Glucocorticoids - Polymyalgia Rheumatica | Phase 3 | Completed | Medical University of Vienna | 39 | 2017-11-24 | 2021-01-22 |
| Safety and Efficacy of tocilizuMAb Versus Placebo in Polymyalgia rHeumatica With glucocORticoid dEpendence SEMAPHORE Tocilizumab, Placebo - Polymyalgia Rheumatica | Phase 3 | Completed | University Hospital, Brest | 113 | 2017-02-15 | 2020-12-04 |
| Timed Release Tablet Prednisone in Polymyalgia Rheumatica Timed Release Tablet Prednisone, Prednisolone - Polymyalgia Rheumatica | Phase 2 / Phase 3 | Completed | University Hospitals Bristol and Weston NHS Foundation Trust | 12 | 2009-10-01 | 2022-09-13 |
| Etanercept Treatment in the Early Course of Polymyalgia Rheumatica Etanercept (Enbrel), Sodium chloride (placebo) - Polymyalgia Rheumatica | Phase 3 | Completed | Bispebjerg Hospital | 40 | 2007-08-01 | 2010-02-23 |
| Prevention of Glucocorticoid-Induced Osteoporosis in Rheumatic Diseases: Alendronate Versus Alfacalcidol. Alendronate versus alfacalcidol (1-alpha OH vitamin D) - Rheumatoid Arthritis, Polymyalgia Rheumatica | Phase 3 | Completed | UMC Utrecht | 200 | 2000-05-01 | 2006-11-29 |
Giant Cell Arteritis (2) · Arteritis (1) · Arthritis, Rheumatoid (1) · Granulomatosis with Polyangiitis (1) · Polymyositis (1) · Rheumatic Diseases (1) · Vascular Diseases (1) · Vasculitis (1)
Connective Tissue Diseases (10) · Muscular Diseases (10) · Musculoskeletal Diseases (10) · Skin and Connective Tissue Diseases (10) · Rheumatic Diseases (9) · Autoimmune Diseases (2) · Autoimmune Diseases of the Nervous System (2) · Brain Diseases (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Cerebrovascular Disorders (2) · Immune System Diseases (2) · Nervous System Diseases (2) · Skin Diseases (2) · Skin Diseases, Vascular (2)
secukinumab (2) · tocilizumab (2) · Abatacept (1) · Etanercept (1) · Glucocorticoids (1) · Prednisolone (1) · Prednisone (1) · Rituximab (1) · Sodium Chloride (1) · prednylidene (1)
Novartis Pharmaceuticals (2) · University Hospital, Brest (2) · Bispebjerg Hospital (1) · Medical University of Vienna (1) · Sint Maartenskliniek (1) · UMC Utrecht (1) · University Hospitals Bristol and Weston NHS Foundation Trust (1) · Zhejiang University (1)
France (3) · Netherlands (3) · Denmark (2) · Germany (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · Chile (1) · China (1) · Colombia (1) · Czechia (1)
Aatke van der Maas, MD PhD (1) · Henrik Galbo, Professor (1) · John R Kirwan, MBBS,MD,FRCP (1) · Weiqian Chen (1)
PMID 39400109, PMID 16914703, PMID 17407214, PMID 17557758, PMID 20854662, PMID 22894827, PMID 35210264, PMID 36125471, PMID 38095675, PMID 38251563, PMID 42234540
2016 (1)