5 completed, 3 active not recruiting, 1 recruiting, 1 suspended. 3 Phase 1, 3 Phase 2, 1 Early Phase 1, 1 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Active not recruiting 2, Recruiting 1 |
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Suspended 1 |
| Early Phase 1 | 1 | Completed 1 |
| Not applicable | 1 | Completed 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8: new trials by email Literature Review of Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8 trials Research Report on Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery Carboplatin, Paclitaxel, Radiation Therapy - Advanced Esophageal Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | Phase 1 | Active not recruiting | NRG Oncology | 16 | 2021-12-02 | 2026-10-01 |
| Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers Adavosertib, Radiation Therapy - Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 4 | 2021-04-09 | 2026-07-31 |
| NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer Capecitabine, Carboplatin, Docetaxel - Cervical Esophagus Adenocarcinoma, Clinical Stage II Esophageal Adenocarcinoma AJCC v8 | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 24 | 2020-11-23 | 2026-10-07 |
| A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE - Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma | Phase 2 | Suspended | Thomas Jefferson University | 48 | 2020-11-10 | 2026-09-14 |
| Remote Telemonitoring of Patient-Generated Physiologic Health Data and Patient-Reported Outcomes Patient Monitoring, Questionnaire Administration - Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 | Completed | City of Hope Medical Center | 22 | 2020-08-11 | 2026-10-14 | |
| Real-Time Monitoring of Chemotherapy Side-Effects in Patients With Gastrointestinal Cancers, RT-CAMSS Study Patient Monitoring System, Questionnaire Administration, Consultation - Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 | Not applicable | Completed | Thomas Jefferson University | 34 | 2020-04-15 | 2025-05-15 |
| Use of Trifluridine/Tipiracil and Oxaliplatin as Induction Chemotherapy for the Treatment of Resectable Esophageal or Gastroesophageal Junction (GEJ) Adenocarcinoma Trifluridine and Tipiracil Hydrochloride, Oxaliplatin - Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8, Clinical Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Completed | Roswell Park Cancer Institute | 22 | 2019-12-20 | 2025-04-29 |
| Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes Biospecimen Collection, Cardiac Event Monitor, Chemoradiotherapy - Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8, Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 | Completed | Mayo Clinic | 24 | 2019-09-23 | 2026-05-27 | |
| Nutritional Supplementation in Reducing Complications in Patients With Locally Advanced Esophageal Cancer Undergoing Chemotherapy, Radiation Therapy, and/or Surgery Nutritional Supplement Drink, Nutritional Supplementation - Clinical Stage III Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Phase 3 | Withdrawn | M.D. Anderson Cancer Center | 2019-03-14 | 2024-02-13 | |
| Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma Atezolizumab, Conventional Surgery, Fluorouracil - Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 43 | 2019-02-19 | 2026-07-28 |
| Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Adenocarcinoma Pembrolizumab - Advanced Gastroesophageal Junction Adenocarcinoma, Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Early Phase 1 | Completed | M.D. Anderson Cancer Center | 9 | 2018-02-09 | 2023-11-18 |
Colorectal Neoplasms (3) · Gastrointestinal Neoplasms (2) · Pancreatic Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Brain Neoplasms (1) · Carcinoma, Renal Cell (1) · Carcinoma, Squamous Cell (1) · Esophageal Squamous Cell Carcinoma (1) · Lung Neoplasms (1) · Meningeal Carcinomatosis (1) · Neoplasms (1) · Neoplasms, Squamous Cell (1) · Ovarian Neoplasms (1) · Prostatic Neoplasms (1) · Urinary Bladder Neoplasms (1)
Neoplasms (5) · Neoplasms by Site (5) · Digestive System Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Diseases (4) · Carcinoma (3) · Colonic Diseases (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Intestinal Diseases (3) · Intestinal Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms, Glandular and Epithelial (3) · Rectal Diseases (3) · Gastrointestinal Neoplasms (2)
Oxaliplatin (3) · Radiation (3) · Radiotherapy (3) · Carboplatin (2) · Fluorouracil (2) · Paclitaxel (2) · Taxes (2) · dehydroftorafur (2) · Capecitabine (1) · Chemoradiotherapy (1) · Dietary Supplements (1) · Docetaxel (1) · Leucovorin (1) · Radiotherapy, Intensity-Modulated (1) · Referral and Consultation (1)
M.D. Anderson Cancer Center (4) · Thomas Jefferson University (2) · City of Hope Medical Center (1) · Mayo Clinic (1) · NRG Oncology (1) · National Cancer Institute (NCI) (1) · Roswell Park Cancer Institute (1)
United States (10)
Babar Bashir, MD (1) · Carlos E. Vargas, M.D. (1) · Christos Fountilas, MD (1) · Eric D Miller (1) · Geoffrey Y Ku (1) · Jaffer A Ajani (1) · Kuang-Yi Wen, MD (1) · Laleh Melstrom (1) · Mariela Blum (1) · Steven H Lin (1) · Wayne L Hofstetter (1)
P30CA033572 (1), U10CA180868 (1), UM1CA186712 (1)