102 completed, 20 unknown, 13 terminated, 10 withdrawn. 45 Not applicable, 28 Phase 3, 22 Phase 2, 17 Phase 4, 11 Phase 1.
Follow Open Angle Glaucoma: new trials by email Literature Review of Open Angle Glaucoma trials Research Report on Open Angle Glaucoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Insulin for Glaucoma (TING2) EYED-002 Low Dose (721 U/mL topical insulin), EYED-002 High Dose (1442 U/mL topical insulin), EYED-002 (highest tolerated dose, 12-month) - Open Angle Glaucoma, Primary Open Angle Glaucoma | Phase 1 / Phase 2 | Enrolling by invitation | Stanford University | 90 | 2026-09-10 | 2026-10-13 |
| Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma iStent infinite trabecular micro-bypass system model iS3, iDose TR (Travoprost intracameral Implant) 75mcg - Open Angle Glaucoma, Pigmentary Glaucoma | Phase 4 | Recruiting | Jonathon Myers | 20 | 2026-01-05 | 2025-11-14 |
| 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients Netarsudil 0.02%/latanoprost 0.005% fixed dose combination ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution - Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Recruiting | Mayo Clinic | 30 | 2025-11-21 | 2026-05-01 |
| Reformulated PG324 Ophthalmic Solution for Intraocular Pressure Reduction Netarsudil 0.01%/latanoprost 0.005% ophthalmic solution, Netarsudil 0.02%/latanoprost 0.005% ophthalmic solution - Ocular Hypertension, Open Angle Glaucoma | Phase 3 | Completed | Alcon Research | 489 | 2025-09-02 | 2026-04-21 |
| Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost Simbrinza 0.2%-1% Ophthalmic Suspension, Rocklatan 0.02%-0.005% Ophthalmic Solution, Cosopt PF 2%-0.5% Ophthalmic Solution - Open Angle Glaucoma | Phase 4 | Recruiting | Prairie Eye Center | 70 | 2025-05-14 | 2025-05-15 |
| Efficacy of Selective Laser Trabeculoplasty Targeting Nasal Versus Inferior 180-degree Nasal 180° Selective Laser Trabeculoplasty (SLT), Inferior 180° Selective Laser Trabeculoplasty (SLT) - Open Angle Glaucoma | Not applicable | Completed | Mayo Clinic | 13 | 2025-01-06 | 2026-01-07 |
| A Phase III Study in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension in China DE-117B Eye Drops, Latanoprost - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Active not recruiting | Santen Pharmaceutical Co., Ltd. | 345 | 2024-11-28 | 2026-05-15 |
| Next Generation Rocklatan AR-17043 Ophthalmic Solution, PG043 Ophthalmic Solution, Latanoprost 0.005% Ophthalmic Solution - Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Completed | Alcon Research | 426 | 2024-09-04 | 2025-11-18 |
| Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCT Ketorolac 0.5% Eye Drops, Ketorolac 0.5% and Fluorometholone 0.1% Eye Drops - Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Unknown | St. Joseph's Healthcare Hamilton | 126 | 2024-09-01 | 2024-07-12 |
| The A D A G I O Study Glaucoma Surgery - Open Angle Glaucoma, Ocular Hypertension | Not yet recruiting | Guy's and St Thomas' NHS Foundation Trust | 150 | 2024-06-01 | 2024-06-12 | |
| An Extension Trial for Patients With Open-Angle Glaucoma Who Participated in the DF6-CL-20-01 Protocol. STREAMLINE® SURGICAL SYSTEM - Open Angle Glaucoma, Intraocular Pressure | Terminated | New World Medical, Inc. | 17 | 2024-06-01 | 2026-03-30 | |
| Safety and Effectiveness of Minimally Invasive Micro Sclerostomy (MIMS®) to Reduce Intraocular Pressure in Open-Angle Glaucoma Which is Not Controlled Despite Polypharmacy Minimally Invasive Micro Sclerostomy Device - Primary Open Angle Glaucoma, Open Angle Glaucoma | Not applicable | Unknown | Sanoculis Ltd | 129 | 2024-06-01 | 2024-08-07 |
| OCTA in Patients With Primary Open-angle Glaucoma OCT angiography - Open Angle Glaucoma | Unknown | Assiut University | 30 | 2024-04-01 | 2024-03-07 | |
| Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution NCX 470, Placebo - Open Angle Glaucoma | Phase 2 / Phase 3 | Completed | Nicox Ophthalmics, Inc. | 18 | 2023-12-12 | 2025-09-08 |
| Comparative Effectiveness and Safety of ELIOS in Patients With Open-Angle Glaucoma Undergoing Cataract Surgery ELIOS, Competitor Device - Open Angle Glaucoma | Not applicable | Recruiting | Elios Vision, Inc. | 194 | 2023-12-05 | 2026-06-17 |
| Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular Hypertension Travoprost Ophthalmic Topical Cream low-dose, Travoprost Ophthalmic Topical Cream mid-dose, Travoprost Ophthalmic Topical Cream high-dose - Open Angle Glaucoma, Ocular Hypertension | Phase 2 | Unknown | Glaukos Corporation | 250 | 2023-11-15 | 2023-12-06 |
| MIMS® Retrospective Chart Review Minimally Invasive Micro Sclerostomy - Open Angle Glaucoma | Completed | Sanoculis Ltd | 34 | 2023-09-27 | 2026-10-15 | |
| Travoprost Intraocular Implant in Conjunction With Cataract Surgery iDose TR - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Unknown | Glaukos Corporation | 60 | 2023-09-11 | 2024-06-03 |
| Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy Trabeculopuncture - Open Angle Glaucoma, Pseudoexfoliation Glaucoma | Not applicable | Recruiting | Wuerzburg University Hospital | 55 | 2023-06-13 | 2025-04-03 |
| TF for the Prediction of Visual Field Progression SENSIMED Triggerfish - Open Angle Glaucoma | Not applicable | Withdrawn | Sensimed AG | 2023-06-01 | 2025-05-15 |
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Glaucoma, Open-Angle (159) · Ocular Hypertension (71) · Glaucoma (44) · Exfoliation Syndrome (9) · Low Tension Glaucoma (8) · Cataract (6) · Glaucoma-Related Pigment Dispersion Syndrome (3) · Eye Diseases (2) · Glaucoma, Angle-Closure (2) · Aniridia (1) · Astigmatism (1) · Axenfeld-Rieger syndrome (1) · Congenital Abnormalities (1) · Corneal Diseases (1) · Dilatation, Pathologic (1)
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Latanoprost (22) · Ophthalmic Solutions (14) · Timolol (8) · Travoprost (8) · netarsudil (8) · Cataract Extraction (5) · Mitomycin (5) · Trabeculectomy (4) · brinzolamide (4) · dorzolamide-timolol combination (4) · Bimatoprost (3) · Brimonidine Tartrate (3) · Xalacom (3) · AR-12286 (2) · Ketorolac (2)
Alcon Research (11) · Aerie Pharmaceuticals (8) · Universitaire Ziekenhuizen KU Leuven (8) · iSTAR Medical (6) · New World Medical, Inc. (5) · Glaukos Corporation (4) · Sanoculis Ltd (4) · University of Colorado, Denver (4) · Nicox Ophthalmics, Inc. (3) · Ocular Therapeutix, Inc. (3) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · Santen Pharmaceutical Co., Ltd. (3) · Sun Pharma Advanced Research Company Limited (3) · University of Zurich (3) · Wills Eye (3)
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PMID 19427617, PMID 36912740, PMID 16877071, PMID 20142538, PMID 20668720, PMID 24182742, PMID 24281785, PMID 24844543, PMID 26066744, PMID 26209587, PMID 27457257, PMID 27526051, PMID 28237137, PMID 28239491, PMID 28442693, PMID 29613978, PMID 30425450, PMID 31301054, PMID 32021070, PMID 33011690, PMID 33244711, PMID 33580495, PMID 33629227, PMID 34433548, PMID 34772665, PMID 35898518, PMID 35909461, PMID 36202141, PMID 36441346, PMID 39477206, PMID 39892748, PMID 39959854, PMID 40799662, PMID 41832303, PMID 42418463, PMID 42530516
2008 (1), UL1TR001082 (1)