Table-Top Water Pitcher to Reduce Arsenic Exposure Among Well Users in New Hampshire

NCT07103356 — Not applicable, Active not recruiting, 25 participants, Trustees of Dartmouth College

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Developing a Hybrid Type 1 Effectiveness-Implementation Randomized Controlled Trial to Test a Table-Top Water Pitcher to Reduce Arsenic Exposure in Northern New England

Registry	NCT07103356
Status	Active not recruiting
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, prevention
Enrollment	25 (Actual)
Sponsor	Trustees of Dartmouth College (Other)
Conditions	Arsenic Poisoning, Environmental Exposure, Water-Related Diseases
Interventions	Water Pitcher Filtration System (Behavioral)
Dates	start 2026-02-24, primary completion 2027-08-31 (estimated), completion 2027-08-31 (estimated), first posted 2025-08-05, last updated 2026-09-28
Locations	1 site in United States

-Summary

The goals of this clinical trial are to:

1. gather preliminary data on the effectiveness of a table-top water pitcher filtration system in reducing arsenic exposure among individuals using private wells with elevated (>5 μg/L) arsenic concentrations, and
2. identify the factors influencing implementation of the filter intervention (uptake and sustainability) and barriers and facilitators to its use.

The main questions it aims to answer are:

Do water and urinary arsenic concentrations change from baseline to Week 4 of the water pitcher intervention?

Are changes in arsenic concentrations maintained during the eight-week sustainability period?

* Which factors facilitate or impede uptake, use, and sustainability of the intervention?
* Are household income and/or home ownership associated with sustained filter use?

Participants will:

* Receive a free 12-cup water filter pitcher and cartridge replacements
* Use the pitcher filtration system, including replacement of filter cartridges, per manufacturer recommendations
* Collect and mail water and urine samples at baseline, 4 weeks, and 12 weeks
* Complete online questionnaires at baseline, 4 weeks, and 12 weeks

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+Arms and interventions

Arm	Type	Interventions	Description
Water Pitcher Filtration System	Experimental	Behavioral: Water Pitcher Filtration System	Arm 1: All participants receive pitcher filter and three replacement filters

Water Pitcher Filtration System (Behavioral): Table-top water pitcher filtration system

+Outcome measures

Primary outcomes

Water arsenic concentrations [4 weeks]: Changes in water arsenic concentrations from baseline to week 4
Urinary arsenic concentrations [4 weeks]: Changes in urinary arsenic concentrations from baseline to week 4
Reach [4 weeks]: Number of participants who receive the water pitcher filtration system among all eligible individuals and demographics
Adoption [4 weeks]: Number of participants using the filtration system after receiving it; number of participants who intend to use the system after the study period ends; and demographics of participants who used the filtration system during the study period or intend to use it after the study period ends
Implementation [4 weeks]: % of participants who adhere to the intervention during the intervention period (Fidelity), including using the pitcher filtration system for all drinking and cooking water and changing filter cartridges as recommended (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)
Maintenance [8 weeks]: % of participants who continue to use the pitcher filtration system during the 8-week sustainability period when replacement filter cartridges are no longer provided (measured by questionnaire: at home, did you use the pitcher filtration system for all of your drinking water, more than half of your drinking water, half of your drinking water, less than half of your drinking water, or none of your drinking water AND did you use did you use the pitcher filtration system for all of your cooking water, more than half of your cooking water, half of your cooking water, less than half of your cooking water, or none of your cooking water)

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

* Age 18 years or older
* NH resident living in Merrimack or Belknap county
* Use a private water system as primary drinking water source
* Water arsenic >5 micrograms/L upon testing
* Confirm would be primary person in home maintaining the provided pitcher filter

Exclusion Criteria:

* Use or plan to use a mitigation strategy to reduce exposure to arsenic-contaminated drinking water in the next 12 weeks

+Locations (1)

Facility	City	Country	Status
Geisel School of Medicine at Dartmouth	Lebanon, New Hampshire	United States