24 completed, 6 unknown, 4 recruiting, 3 terminated. 41 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 41 | Completed 24, Unknown 6, Recruiting 4, Terminated 3, Not yet recruiting 2, Active not recruiting 1, Suspended 1 |
Follow Neurofibromatoses: new trials by email Literature Review of Neurofibromatoses trials Research Report on Neurofibromatoses
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs) GentleMax Pro (with skin cooling), GentleMax Pro (without skin cooling) - Neurofibromatosis 1 (NF1), Neurofibromatosis Type I | Not applicable | Suspended | Massachusetts General Hospital | 10 | 2027-01-01 | 2026-06-04 |
| Cognitive Intervention for Children and Adolescents With NF1 Unstuck and On Target! - Neurofibromatosis 1 (NF1), Executive Function (Cognition) | Not applicable | Not yet recruiting | The Hospital for Sick Children | 60 | 2026-09-28 | 2026-10-13 |
| iCanCope With NF: Innovating an Efficacious Digital Self-management and Transitional Care Program for Adolescents With Neurofibromatosis iCanCope-NF Youth app, iCanCope-NF Youth app + CM - Neurofibromatosis 1 | Not applicable | Not yet recruiting | The Hospital for Sick Children | 60 | 2026-03-01 | 2025-07-22 |
| Assessment of Patient Experience With Auto-Captioning Glasses in NF2-Related-Schwannomatosis Auto-captioning Glasses - NF2-related Schwannomatosis | Not applicable | Completed | Massachusetts General Hospital | 18 | 2026-02-19 | 2026-08-25 |
| A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1) AlgometRx Nociometer(R) - Neurofibromatosis Type 1 | Not applicable | Recruiting | National Cancer Institute (NCI) | 70 | 2026-02-18 | 2026-10-16 |
| Tailoring an Online Platform to Promote Evidence-Based Care for Adults With Neurofibromatosis 1 and Low Health Literacy NF1 Educational Videos, Peer Navigator, Letters about NF1 Care - Neurofibromatosis 1 | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2025-12-28 | 2026-07-15 |
| A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1 Letters about NF1 Care (Content Type 1), Letters about NF1 Care (Content Type 2) - Neurofibromatosis 1 | Not applicable | Completed | Massachusetts General Hospital | 294 | 2024-12-03 | 2026-08-21 |
| Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial Waitlist, ACT Intervention - Neurofibromatosis 1, Noonan Syndrome | Not applicable | Recruiting | National Cancer Institute (NCI) | 70 | 2024-01-10 | 2026-10-16 |
| Mindful Parenting - A Single Case Experimental Design Study Mindful Parenting Programme - Parenting, Alopecia | Not applicable | Unknown | Cardiff University | 12 | 2023-01-03 | 2023-03-22 |
| Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence Whole-body Magnetic Resonance Imaging - Neurofibromatosis Type 1 | Not applicable | Recruiting | Nicole Baca | 15 | 2022-07-08 | 2026-05-07 |
| Clinical Hypnosis and Home Blood Pressure Monitoring in Children With Neurofibromatosis Type 1 Group 1. Standard Home Blood Pressure Measurement, Group 2. Hypnosis script prior to home blood pressure measurement - Hypertension, Neurofibromatosis 1 | Not applicable | Completed | Murdoch Childrens Research Institute | 54 | 2022-05-25 | 2025-02-24 |
| Intervention Effectiveness on the Neurocognitive Functioning of Children and Adolescents With Neurofibromatosis Type 1 OPTIMAL-SSI - Neurocognitive Deficit, Mental Health Impairment | Not applicable | Completed | Virginia Commonwealth University | 38 | 2022-05-13 | 2023-09-22 |
| Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical Trial iCanCope, iCanCope+Contingency Management - Neurofibromatosis 1, Chronic Pain | Not applicable | Completed | Yale University | 122 | 2021-03-01 | 2025-03-30 |
| Pilot Randomized Control Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1 PEERS - Neurofibromatosis 1, Social Skills | Not applicable | Unknown | University of Wisconsin, Milwaukee | 30 | 2021-01-29 | 2021-04-26 |
| Open Trial of Telehealth Group for Improving Peer Relationships (PEERS) in NF1 PEERS - Neurofibromatosis 1, Social Skills | Not applicable | Unknown | University of Wisconsin, Milwaukee | 8 | 2020-12-05 | 2021-04-27 |
| Quality Improvement Project - "My Logbook! - I Know my Way Around!"; ("Mein Logbuch - Ich Kenne Mich Aus!") "My Logbook! - I know my way around!" - Brain Tumor, Neurofibromatoses | Not applicable | Completed | Medical University of Vienna | 240 | 2020-09-07 | 2024-01-09 |
| Vestibular Precision: Physiology & Pathophysiology VOR precision training - Vestibular Schwannoma, Inner Ear Disease | Not applicable | Unknown | Massachusetts Eye and Ear Infirmary | 90 | 2020-07-01 | 2023-03-16 |
| Resiliency Training in Adolescents With NF1 and NF2 Stress and Symptom Management Program 1, Stress and Symptom Management Program 2 - Neurofibromatoses | Not applicable | Completed | Massachusetts General Hospital | 196 | 2019-12-15 | 2026-06-11 |
| Whole-body Vibration in Children With Neurofibromatosis Type 1 Whole-body vibration, Muscle strengthening exercises - Neurofibromatosis Type 1, Muscle Weakness | Not applicable | Completed | Manchester University NHS Foundation Trust | 30 | 2019-07-22 | 2021-03-16 |
| Comparison of Gastrointestinal Motility in Healthy Children and Children With Constipation 3D-Transit - Constipation, Childhood Acute Lymphoblastic Leukemia | Not applicable | Unknown | University of Aarhus | 80 | 2019-06-13 | 2020-11-25 |
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Neurofibromatosis 1 (33) · Neurofibromatosis 2 (7) · Neurofibroma, Plexiform (4) · Dyslexia (3) · Brain Neoplasms (2) · Schwannomatosis (2) · Social Skills (2) · Alopecia (1) · Autism Spectrum Disorder (1) · Behavior (1) · Cardiofaciocutaneous syndrome (1) · Chronic Pain (1) · Cleft Lip (1) · Constipation (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (41) · Heredodegenerative Disorders, Nervous System (41) · Neoplasms by Histologic Type (41) · Neoplasms, Nerve Tissue (41) · Neoplastic Syndromes, Hereditary (41) · Nerve Sheath Neoplasms (41) · Nervous System Diseases (41) · Neurocutaneous Syndromes (41) · Neurodegenerative Diseases (41) · Genetic Diseases, Inborn (40) · Neoplasms (40) · Neurofibroma (40) · Neuromuscular Diseases (33) · Peripheral Nervous System Diseases (33)
Magnetic Resonance Imaging (3) · Transcranial Direct Current Stimulation (2) · Fluorodeoxyglucose F18 (1) · Gadolinium DTPA (1) · Genetic Testing (1) · Lasers (1) · Lasers, Solid-State (1) · Lovastatin (1) · Neuropsychological Tests (1) · Surveys and Questionnaires (1) · Waiting Lists (1) · gadolinium compound P760 (1)
Massachusetts General Hospital (9) · National Cancer Institute (NCI) (3) · University Hospital, Toulouse (3) · Manchester University NHS Foundation Trust (2) · The Hospital for Sick Children (2) · University of Manchester (2) · University of Wisconsin, Milwaukee (2) · Cardiff University (1) · Case Comprehensive Cancer Center (1) · Children's Hospital of Philadelphia (1) · Children's National Research Institute (1) · Kristina Hardy (1) · Massachusetts Eye and Ear Infirmary (1) · Medical University of Vienna (1) · Murdoch Childrens Research Institute (1)
United States (26) · United Kingdom (5) · France (4) · Australia (1) · Austria (1) · Denmark (1) · Germany (1) · Italy (1) · Portugal (1) · Switzerland (1)
Ana-Maria Vranceanu, PhD (4) · Vanessa Merker, PhD (3) · Staci M Peron, Ph.D. (2) · Ana-Maira Vranceanu, PhD (1) · Bonnie Klein-Tasman, PhD (1) · Busi Zapparoli, Ph.D., C.Psych. (1) · Danielle Glad, M.S. (1) · David Gutmann, M.D., Ph.D. (1) · David Stevenson, MD (1) · Deborah R Gold, MD (1) · Gabriel Dabscheck, MBBS FRACP (1) · Jennifer M Rohan, PhD (1) · John Gore, Ph.D. (1) · Kaleb H Yohay, MD (1) · Kristina Hardy, PhD (1)
PMID 38908005, PMID 30355560, PMID 32421171, PMID 33507832, PMID 34091540, PMID 34409538, PMID 34570301, PMID 35064449, PMID 35925531, PMID 35970940, PMID 36651958, PMID 37378983, PMID 37440099, PMID 37608248, PMID 38318960, PMID 39107671, PMID 39538073, PMID 39917761, PMID 40773151, PMID 42631525
R01NS049096 (1)