17 completed, 6 unknown, 2 active not recruiting, 2 terminated. 28 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 28 | Completed 17, Unknown 6, Active not recruiting 2, Terminated 2, Not yet recruiting 1 |
Follow Neoplastic Syndromes, Hereditary: new trials by email Literature Review of Neoplastic Syndromes, Hereditary trials Research Report on Neoplastic Syndromes, Hereditary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cold Snare Polypectomy for Small Bowel Polyps in Patients With Peutz-Jeghers Syndrome Cold snare polypectomy - Peutz-Jeghers Syndrome, Small Bowel Polyp | Phase 4 | Unknown | Shandong University | 40 | 2023-08-20 | 2023-08-21 |
| A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex Cannabidiol Oral Solution [Epidiolex] - Tuberous Sclerosis Complex Associated Neuropsychiatric Disease | Phase 4 | Completed | Jazz Pharmaceuticals | 79 | 2023-06-29 | 2026-04-27 |
| A Phase IV Study of Safety and Efficacy of Everolimus in Taiwanese Patients With Tuberous Sclerosis Complex Who Have Renal Angiomyolipoma (TSC-AML) Everolimus - Renal Angiomyolipoma | Phase 4 | Completed | Novartis Pharmaceuticals | 4 | 2023-05-01 | 2026-10-29 |
| Study to Assess the Safety of Alpelisib Plus Fulvestrant, in Men and Post-menopausal Women With HR-positive, HER2-negative, Advanced Breast Cancer (aBC) With PIK3CA Mutation, Whose Disease Progressed on or After Endocrine Treatment Alpelisib, Fulvestrant - Advanced Breast Cancer | Phase 4 | Completed | Novartis Pharmaceuticals | 40 | 2022-08-09 | 2026-07-09 |
| Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution Cannabidiol - Lennox Gastaut Syndrome, Dravet Syndrome | Phase 4 | Active not recruiting | Jazz Pharmaceuticals | 154 | 2021-07-07 | 2026-08-26 |
| Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Azithromycin Tablets - Familial Adenomatous Polyposis | Phase 4 | Unknown | Tel-Aviv Sourasky Medical Center | 10 | 2020-08-01 | 2020-07-01 |
| Pediatric Long-Term Follow-up and Rollover Study dabrafenib, trametinib - Diffuse Astrocytoma, Anaplastic Astrocytoma | Phase 4 | Active not recruiting | Novartis Pharmaceuticals | 163 | 2019-11-04 | 2026-08-27 |
| Combination Therapy of Anthracyclines for Children With Nephroblastoma Vincristine, Oxytetracycline/ Cyclophosphamide, Liposomal doxorubicin - 0.5-14 Year Old Children With Nephroblastoma | Phase 4 | Not yet recruiting | Shengjing Hospital | 120 | 2019-06-01 | 2019-03-27 |
| Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex. Everolimus - Renal Angiomyolipoma | Phase 4 | Completed | Novartis Pharmaceuticals | 40 | 2018-11-09 | 2021-09-09 |
| Efficacy of Rapamycin (Sirolimus) in the Treatment of Peutz-Jeghers Syndrome Rapamycin - Peutz-Jeghers Syndrome | Phase 4 | Unknown | Peking Union Medical College Hospital | 10 | 2018-09-16 | 2019-01-23 |
| Dexmedetomidine and Propofol for Pediatric MRI Sedation propofol, Dexmedetomidine, Glycopyrrolate - Headache, Tumor | Phase 4 | Completed | Medical College of Wisconsin | 40 | 2018-03-04 | 2020-02-21 |
| Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted Version Erythromycin - FAP-Familial Adenomatous Polyposis | Phase 4 | Unknown | michal roll | 15 | 2015-06-01 | 2015-02-03 |
| Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis Erythromycin - FAP-Familial Adenomatous Polyposis | Phase 4 | Unknown | michal roll | 20 | 2014-06-01 | 2014-06-26 |
| Protexa® Versus TiLoopBra® in Immediate Breast Reconstruction- A Pilot Study TiLoop Bra, Protexa - Breast Cancer, Hereditary Breast and Ovarian Cancer Syndrome | Phase 4 | Completed | Medical University of Vienna | 50 | 2013-07-01 | 2015-09-29 |
| GRK4 Polymorphisms Blood Pressure Response to Candesartan Candesartan - Essential Hypertension | Phase 4 | Unknown | Third Military Medical University | 500 | 2013-07-01 | 2014-11-18 |
| Effects of Growth Hormone Administration on Muscle Strength and Body Composition in Men Over 50 Years Old growth hormone - Healthy | Phase 4 | Completed | Universidade Federal do Rio de Janeiro | 13 | 2012-01-01 | 2014-09-03 |
| How Much Vitamin D is Required to be Protective Against Deficiency During the Winter Months? Vitamin D, placebo - Vitamin D Deficiency | Phase 4 | Completed | McGill University | 77 | 2011-10-01 | 2014-09-05 |
| Effects of Diet-induced Weight Loss in Obese Men Optifast, Conventional diet counseling - Sexual Dysfunction, Endothelial Dysfunction | Phase 4 | Completed | Changi General Hospital | 70 | 2010-12-01 | 2015-07-29 |
| Sabril for Complex Partial Seizures in Adult Tolerability Study (TS) Patients vigabatrin - Complex Partial Seizures | Phase 4 | Terminated | University of Pennsylvania | 1 | 2010-08-01 | 2017-07-12 |
| Comparing Effects of Diet, With or Without Exercise, on Sexual, Urinary and Endothelial Function, Inflammatory Profile and Quality of Life in Obese Men weight loss counselling - Sexual Dysfunction, Endothelial Dysfunction | Phase 4 | Completed | Changi General Hospital | 90 | 2010-07-01 | 2015-07-29 |
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Multiple Endocrine Neoplasia Type 1 (9) · Tuberous Sclerosis (6) · Adenomatous Polyposis Coli (4) · Inflammation (4) · Obesity (3) · Sexual Dysfunction, Physiological (3) · Angiomyolipoma (2) · Lymphangioleiomyomatosis (2) · Neuroblastoma (2) · Neurofibromatosis 1 (2) · Peutz-Jeghers Syndrome (2) · Seizures (2) · Wilms Tumor (2) · Abdominal Neoplasms (1) · Astrocytoma (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (28) · Genetic Diseases, Inborn (28) · Neoplasms (27) · Neoplasms by Site (19) · Neoplasms, Multiple Primary (16) · Neoplasms by Histologic Type (12) · Endocrine Gland Neoplasms (11) · Endocrine System Diseases (11) · Nervous System Diseases (11) · Heredodegenerative Disorders, Nervous System (10) · Neurodegenerative Diseases (10) · Multiple Endocrine Neoplasia (9) · Neurocutaneous Syndromes (9) · Pathological Conditions, Signs and Symptoms (9)
Cannabidiol (2) · Erythromycin (2) · Everolimus (2) · Alpelisib (1) · Anti-Bacterial Agents (1) · Azithromycin (1) · Cyclophosphamide (1) · Dexmedetomidine (1) · Diet (1) · Doxorubicin (1) · Doxycycline (1) · Duration of Therapy (1) · Dutasteride (1) · Epirubicin (1) · Exercise (1)
Novartis Pharmaceuticals (4) · Changi General Hospital (3) · Jazz Pharmaceuticals (2) · michal roll (2) · Assistance Publique - Hôpitaux de Paris (1) · Charles Mel Wilcox, MD (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Hospices Civils de Lyon (1) · McGill University (1) · Medical College of Wisconsin (1) · Medical University of Vienna (1) · Merck Sharp & Dohme LLC (1) · Peking Union Medical College Hospital (1) · Samsung Medical Center (1) · Shandong University (1)
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C. Mel Wilcox, M.D. (1) · Daphne Gschwantler-Kaulich, Ass.Prof.Dr. (1) · Hope A Weiler, PhD, RD (1) · Jiaolin Zhou, MD (1) · Joan J Khoo, MRCP (1) · Joan Khoo, MBBS,MRCP (1) · Joan Khoo, MRCP (1) · John Pollard, MD (1) · KiWoong Sung, MD, PhD (1) · Louis Bernard, PU-PH (1)
PMID 15645403, PMID 17767471, PMID 18507843, PMID 19581810, PMID 20018966, PMID 21073392, PMID 21193359, PMID 21319349, PMID 22396515, PMID 23635309, PMID 24382963, PMID 25205361, PMID 25468170, PMID 25984880, PMID 26201019, PMID 26438497, PMID 26871769, PMID 26947961, PMID 29280355, PMID 42435131, PMID 42544942
2023 (2), R01HD043348 (1)