10 completed, 10 terminated, 8 recruiting, 5 active not recruiting. 42 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 42 | Completed 10, Terminated 10, Recruiting 8, Active not recruiting 5, Not yet recruiting 4, Withdrawn 3, Unknown 2 |
Follow Neoplasm Metastasis: new trials by email Literature Review of Neoplasm Metastasis trials Research Report on Neoplasm Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IL-15 Enhanced NK Cell Therapy for Solid Tumors IL-15 enhanced engineered NK cells, IL-15 Enhanced Engineered NK Cells - Solid Tumors, Metastatic Cancer | Early Phase 1 | Recruiting | Genovn Therapeutics (Suzhou) Co., Ltd. | 12 | 2026-10-08 | 2026-09-30 |
| Response With Interim PSMA PET in Metastatic Castration-sensitive Prostate Cancer for Optimization of Adaptive Metastasis-directed Radiotherapy Delivery Drug: 68-Ga PSMA11, Adaptive stereotactic ablative radiotherapy (SABR), 68Ga-PSMA-11 - Prostate Cancer, Castration Sensitive Prostate Cancer | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 30 | 2026-10-01 | 2026-08-24 |
| Pilot Study of TumorGlow for Intraoperative Molecular Imaging of Sarcoma Metastases to the Lungs in Pediatric Patients ICG INFUSION 5MG/KG - Sarcoma Metastatic | Early Phase 1 | Recruiting | Abramson Cancer Center at Penn Medicine | 20 | 2026-07-29 | 2026-11-02 |
| Inhaled mRNA Immunotherapy for Patients With Advanced Lung Cancer or Pulmonary Metastatic Solid Tumors Inhaled mRNA - Neoplasms, Solid Tumors | Early Phase 1 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 60 | 2026-06-10 | 2026-06-18 |
| Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy [68Ga]Ga-ABY-025 - Locally Advanced Cancer, Metastatic Cancer | Early Phase 1 | Recruiting | Vanderbilt-Ingram Cancer Center | 30 | 2026-04-16 | 2026-05-08 |
| Phase I, FIH, MTD for MPT0B640, Multi-centre, Open-label, Subject With Locally Advanced or Metastatic Solid Malignancies MPT0B640 - Advanced Solid Tumor, Metastatic Solid Tumor | Early Phase 1 | Withdrawn | J Ints Bio | 2025-12-01 | 2024-03-06 | |
| Feasibility Study of Personalized Ultra-fractionated Stereotactic Ablative Radiotherapy (PULSAR) for Cancers of the Central Lung Personalized Ultra-fractionated stereotactic ablative radiotherapy (PULSAR) - Cancer, Lung, Metastasis | Early Phase 1 | Recruiting | University of Texas Southwestern Medical Center | 30 | 2025-09-19 | 2026-06-29 |
| Safety and Efficacy Evaluation of Anti IGF-1R Monoclonal Antibody Combined With Anti-PD-1 Monoclonal Antibody in Treatment in Patients With Metastatic Castration-Resistant Prostate Cancer anti-IGF-1R mAb (Teprotumumab/IBI311) + anti-PD-1 mAb (Tislelizumab) - mCRPC | Early Phase 1 | Active not recruiting | Shanghai Changzheng Hospital | 7 | 2025-03-10 | 2026-07-23 |
| Allogeneic B7H3 CAR-γδT Cell Therapy for Advanced Solid Tumors Fludarabine, Cyclophosphamide, B7H3 CAR-γδT cells - Advanced Solid Tumors, Ovarian Cancers | Early Phase 1 | Not yet recruiting | Peking University | 18 | 2025-03-01 | 2025-02-13 |
| CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors CDH17 CAR-T, FAST LACO-Stim CDH17 CAR-T - Biliary Tract Cancer, Colorectal Carcinoma | Early Phase 1 | Recruiting | Zhejiang University | 36 | 2024-12-26 | 2026-05-26 |
| Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma INCB081776, Pembrolizumab, Palliative RT - Head and Neck Squamous Cell Carcinoma | Early Phase 1 | Active not recruiting | University of Wisconsin, Madison | 10 | 2024-09-18 | 2026-05-26 |
| Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases Arginine, Biospecimen Collection, Computed Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Early Phase 1 | Recruiting | Emory University | 10 | 2024-09-05 | 2026-10-13 |
| CSF CTC-Capture-Guided EGFR-TKI and Bevacizumab Combination Therapy in EGFR-Mutant Advanced NSCLC Osimertinib 80 MG, Bevacizumab - Non Small Cell Lung Cancer, Circulating Tumor Cell | Early Phase 1 | Not yet recruiting | Second Affiliated Hospital of Nanchang University | 100 | 2024-08-20 | 2024-08-16 |
| Clinical Study of Safety and Efficacy of Enhanced PSMA CAR- T in Refractory CRPC Enhanced autologous PSMA-CAR T - Metastatic Castration-resistant Prostate Cancer, Castration-resistant Prostate Cancer | Early Phase 1 | Active not recruiting | Shanghai Changzheng Hospital | 18 | 2024-03-03 | 2026-07-23 |
| 64Cu-DOTA Pembrolizumab for Imaging Metastatic Solid Tumors in Patients Receiving Stereotactic Body Radiation Copper Cu 64-DOTA-pembrolizumab, Positron Emission Tomography, Stereotactic Body Radiation Therapy - Metastatic Malignant Solid Neoplasm | Early Phase 1 | Withdrawn | City of Hope Medical Center | 2023-08-25 | 2023-10-10 | |
| Spatiotemporal Stereotactic Body Radiation Therapy for the Treatment of Patients With Polymetastatic Solid Tumors Biospecimen Collection, Computed Tomography, Stereotactic Body Radiation Therapy - Metastatic Malignant Solid Neoplasm | Early Phase 1 | Recruiting | City of Hope Medical Center | 20 | 2023-04-27 | 2026-08-19 |
| Using a PET Imaging Agent, 18F-Clofarabine (CFA), to Measure Deoxycytidine Kinase Activity in Metastatic Cancer 18F-Clofarabine - Metastatic Cancer, Carcinoma | Early Phase 1 | Terminated | Roberto Vargas | 5 | 2023-03-06 | 2026-08-07 |
| Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma Cabozantinib, Ipilimumab, Nivolumab - Renal Cell Carcinoma | Early Phase 1 | Completed | Icahn School of Medicine at Mount Sinai | 10 | 2023-02-15 | 2026-09-24 |
| A Novel Method for Treating Lung Met w/Combo of Electric Fields & Rad Therapy: A Single-Arm Irreversible electroporation (IRE) ablation, Radiation Therapy - Lung Tumor, Metastatic Cancer | Early Phase 1 | Completed | University of California, Irvine | 6 | 2023-01-03 | 2025-05-14 |
| Cholesterol Disruption in Combination With the Standard of Care in Patients With Advanced Pancreatic Adenocarcinoma Cholesterol metabolism disruption - Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | Early Phase 1 | Active not recruiting | CHU de Quebec-Universite Laval | 3 | 2021-10-04 | 2026-03-19 |
Showing 20 of 42. Sign in to see all of them.
Neoplasms (10) · Brain Neoplasms (6) · Prostatic Neoplasms (6) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Carcinoma, Renal Cell (3) · Lung Neoplasms (3) · Neoplastic Cells, Circulating (3) · Intraocular Lymphoma (2) · Melanoma (2) · Ovarian Neoplasms (2) · Pancreatic Neoplasms (2) · Sarcoma (2) · Small Cell Lung Carcinoma (2)
Neoplastic Processes (42) · Pathologic Processes (42) · Pathological Conditions, Signs and Symptoms (42) · Neoplasms (32) · Neoplasms by Site (28) · Urogenital Diseases (12) · Urogenital Neoplasms (12) · Genital Diseases (10) · Neoplasms by Histologic Type (10) · Male Urogenital Diseases (9) · Genital Diseases, Male (7) · Genital Neoplasms, Male (7) · Neoplasms, Glandular and Epithelial (7) · Nervous System Diseases (7) · Prostatic Diseases (7)
Magnetic Resonance Spectroscopy (4) · Cyclophosphamide (3) · Radiosurgery (3) · Ipilimumab (2) · Positron Emission Tomography Computed Tomography (2) · Radiotherapy (2) · Specimen Handling (2) · pembrolizumab (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Abiraterone Acetate (1) · Arginine (1) · Atorvastatin (1) · Bevacizumab (1) · Calcium Dobesilate (1) · Citric Acid (1)
Abramson Cancer Center at Penn Medicine (2) · City of Hope Medical Center (2) · Emory University (2) · First Affiliated Hospital of Fujian Medical University (2) · M.D. Anderson Cancer Center (2) · Shanghai Changzheng Hospital (2) · University of Texas Southwestern Medical Center (2) · Albert Einstein College of Medicine (1) · CHU de Quebec-Universite Laval (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Capital Medical University (1) · Case Comprehensive Cancer Center (1) · Cedars-Sinai Medical Center (1) · Centre Georges Francois Leclerc (1) · Columbia University (1)
United States (26) · China (9) · Canada (1) · France (1) · Switzerland (1)
Akhila S Reddy (1) · Andrew S. Poklepovic, MD (1) · Anne Gangloff, MD PhD FRCPC (1) · Anne-Marie Carreau, MD FRCPC (1) · Christian Kurzeder, PD Dr. med (1) · Deric Wheeler, PhD (1) · Eric J Miller (1) · Ethan Seah (1) · Francine Aubin, MD FRCPC (1) · Ira Braunschweig (1) · Jeffrey J. Raizer, MD (1) · Jeremy Harris, MD (1)
PMID 29180633, PMID 34424505, PMID 35551610, PMID 36723892, PMID 38782459, PMID 39402027, PMID 39856336, PMID 40803526
P30CA033572 (2), P30CA138292 (2), 2019 (1), P30CA006973 (1), P30CA013330 (1), P30CA043703 (1), P30CA046934 (1), P50CA278595 (1)