33 completed, 16 unknown, 11 active not recruiting, 10 recruiting. 40 Not applicable, 18 Phase 2, 8 Phase 1, 1 Early Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic Cancer Personalized cancer vaccine including : DNA neoantigen vaccine, MVA viral vector and Ipilimumab (anti-CTLA4) - Metastatic Colorectal Cancer (CRC), Locally Advanced Colorectal Cancer | Phase 1 | Not yet recruiting | Centre Georges Francois Leclerc | 77 | 2026-11-01 | 2026-05-14 |
| A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer TheraSphere - Gastrointestinal Cancer | Not applicable | Not yet recruiting | Centre Georges Francois Leclerc | 18 | 2026-10-01 | 2026-05-13 |
| Clinical Trial Evaluating the Safety and Efficacy of Chemoimmunotherapy Plus Short Course of Mek Inhibitor in First Line of Treatment of Metastatic Non Squamous Non Small Cell Lung Adenocarcinoma With PDL1 < 50 %. Phase I - Mirdametinib - Level 1, Phase II - Mirdametinib, Phase I - Mirdametinib - Level 2 - Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Recruiting | Centre Georges Francois Leclerc | 24 | 2026-07-07 | 2026-07-09 |
| A Study Evaluating the Contribution of Non-Coplanar Beam Arrangement in Reducing Toxicity in Radiotherapy for Upper Aerodigestive Tract Cancers Coplanar External Beam Radiotherapy, Non-Coplanar External Beam Radiotherapy - Squamous Cell Carcinoma of the Oral Cavity and Oropharynx | Not applicable | Not yet recruiting | Centre Georges Francois Leclerc | 70 | 2026-04-01 | 2026-02-18 |
| Predicting Response to Anti-PD-1/PD-L1 Immunotherapy by Plasma Extracellular Vesicle Analysis Non-Small Cell Lung Cancer, Melanoma (Skin Cancer) | Not yet recruiting | Centre Georges Francois Leclerc | 378 | 2026-03-01 | 2026-01-29 | |
| Emergence of Bacterial Resistance to Antibiotics in the Digestive Microbiota of Patients Treated With Anticancer Drugs Mandatory biological samples (blood and sell) - Cervical Cancers, Endometrial Cancer | Not applicable | Not yet recruiting | Centre Georges Francois Leclerc | 260 | 2025-09-01 | 2025-07-30 |
| Evaluation of the Effect of Adapted Physical Activity on the Modification of Lipid Metabolism During Chemotherapy for Metastatic COLorectal Cancer Lipidomic analyses, Adapted physical activity program - Metastatic Colorectal Cancer (CRC), Volunteer Subjects | Phase 2 | Not yet recruiting | Centre Georges Francois Leclerc | 54 | 2025-06-01 | 2025-04-30 |
| Study of Cancer Patients' Preferences for Genetic Information Modalities Preceding Theranostic Exome Analysis. Cancer patients' preferences regarding genetic information modalities prior to theranostic exome analysis - All Types of Metastatic Solid Malignancy, 1st-line Treatment | Not applicable | Recruiting | Centre Georges Francois Leclerc | 80 | 2024-09-19 | 2025-02-18 |
| Use of an Ultra-rapid BRCA1/2 Status Screening Test in Diagnostic and Theranostic Indication: Performance and Interest for Patients and Practitioners Questionnaires, Communication of the results of the BRCA1/2 ultra rapid test - Breast Cancer | Recruiting | Centre Georges Francois Leclerc | 150 | 2024-06-12 | 2025-04-22 | |
| Randomized Study Versus Placebo for the Prevention of Neurotoxicity Induced by Weekly PACLITAXEL OnLife®, Placebo - Breast Cancer | Phase 2 | Unknown | Centre Georges Francois Leclerc | 60 | 2024-04-12 | 2024-04-22 |
| Evaluation of the Concordance Between Pre-therapy Dosimetry Performed From 68Ga-PSMA-11 Dynamic PET and Post-treatment Dosimetry of 177Lu-PSMA-617 Vectorized Internal Radiotherapy in Patients With Metastatic Prostate Cancer Resistant to Hormonal Castration. 177Lu-PSMA-617 PET scan - Patients With Metastatic Castration-resistant Prostate Cancer | Not applicable | Not yet recruiting | Centre Georges Francois Leclerc | 35 | 2024-01-31 | 2023-11-18 |
| Trial Evaluating the Efficacy and the Safety of FOLFIRINOX3 Treatment in Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer in First Line of Chemotherapy FOLFIRINOX treatment - Metastatic Pancreatic Cancer | Phase 2 | Recruiting | Centre Georges Francois Leclerc | 90 | 2024-01-24 | 2024-02-12 |
| Influence of Food Preferences on the Occurrence of Undernutrition in Treated Patients for Bronchopulmonary Carcinoma Non-small Cell Stage IV Test Leeds Food Preference Questionnaire (LFQP-France) - Non-small Cell Bronchopulmonary Carcinoma at Stage IV and Benefiting From First-line Treatment According to Current French Recommendations | Not applicable | Active not recruiting | Centre Georges Francois Leclerc | 190 | 2023-11-01 | 2025-12-01 |
| Impact of Non-magnetic Screen Respiratory Self-guidance During MRI-guided Radiotherapy Sessions for Mobile Lesions With non-magnetic screen - Patient With Radiotherapy (Linac MRI), Mobile Cancerous Lesion | Not applicable | Recruiting | Centre Georges Francois Leclerc | 100 | 2023-10-16 | 2025-02-17 |
| Study Evaluating the Safety and the Efficacy of Combination of Atezolizumab, Tiragolumab and and Stereotactic Body Radiation Therapy in Patients With Oligometastatic Multiorgan (IMMUNOs-SBRT) Atezolizumab 60 MG/1 ML Intravenous Solution [TECENTRIQ], Tiragolumab, Stereotactic body radiation therapy (SBRT) - Metastatic Non Small Cell Lung Cancer, Metastatic Bladder Cancer | Phase 1 | Unknown | Centre Georges Francois Leclerc | 92 | 2022-12-05 | 2023-10-17 |
| Functional Evaluation After Breast Reconstruction With a Minimally Invasive Latissimus Dorsi Flap Following Radical Surgery for Breast Cancer. Surgery for unilateral breast reconstruction - Breast Cancer | Not applicable | Active not recruiting | Centre Georges Francois Leclerc | 32 | 2022-11-25 | 2025-12-26 |
| Evaluation of Efficacy of Trifluridine/Tipiracil Plus an Anti-IL-1α True Human Antibody Versus Trifluridine/Tipiracil Plus Placebo in Metastatic Colorectal Cancer Patients After Failure of Oxaliplatin, Irinotecan, Fluoropyrimidine trifluridine/tipiracil + XB2001, trifluridine/tipiracil + placebo - Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Active not recruiting | Centre Georges Francois Leclerc | 160 | 2022-10-13 | 2025-05-30 |
| Evaluation and Modeling of the Effect of G-CSF on the Evolution of Polynuclear Neutrophils During Dense Dose Epirubicin-Cyclophosphamide Regeneration Dense dose epirubicin-cyclophosphamide chemotherapy and G-CSF (filgrastim, lenograstim), Dense dose epirubicin-cyclophosphamide chemotherapy with administration of peg-G-CSF (pegfilgrastim) - Localized Breast Cancer | Not applicable | Completed | Centre Georges Francois Leclerc | 97 | 2022-09-02 | 2026-02-19 |
| Evaluation of the Unconformity of the Hormonal Status of Metastatic Lesions During a First Relapse of Breast Cancer Initially Expressing Estrogen Receptors: a Pilot Study on the Interest of PET With FES FES PET - FES TEP in Detection of Estrogen Receptors | Not applicable | Unknown | Centre Georges Francois Leclerc | 25 | 2021-10-18 | 2024-02-13 |
| Mechanisms of Anti COVID-19 Humoral and Cellular Immune Response After Vaccination in a Sample of Patients and Salaried Staff From a French Anti-cancer Center serology and ELISPOT test, serology - Cancer | Not applicable | Completed | Centre Georges Francois Leclerc | 539 | 2021-06-02 | 2023-10-11 |
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Breast Neoplasms (17) · Neoplasms (13) · Colorectal Neoplasms (10) · Carcinoma, Non-Small-Cell Lung (5) · Prostatic Neoplasms (5) · Glioblastoma (4) · Pancreatic Neoplasms (4) · Lung Neoplasms (3) · Patient Compliance (3) · Sarcoma (3) · Genetic Predisposition to Disease (2) · Head and Neck Neoplasms (2) · Kidney Neoplasms (2) · Liver Neoplasms (2) · Melanoma (2)
Blood Specimen Collection (9) · Radiotherapy (5) · Fluorodeoxyglucose F18 (2) · Granulocyte Colony-Stimulating Factor (2) · Radiosurgery (2) · Surveys and Questionnaires (2) · Temozolomide (2) · durvalumab (2) · tremelimumab (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bevacizumab (1) · Biopsy (1) · Brachytherapy (1) · Carboplatin (1) · Docetaxel (1)
France (79) · Belgium (1) · Italy (1)
Pierre Fumoleau, Pr (3) · Antoine Serre, MD (1) · Bruno Chauffert, Professor (1) · Charles Coutant, PU-PH (1) · Franck Bonnetain, PhD (1) · Franck Chauvin, PhDMD (1)
PMID 23122780, PMID 24723487, PMID 25070543, PMID 25256896, PMID 26228970, PMID 26371288, PMID 26467471, PMID 27388807, PMID 29482777, PMID 29560093, PMID 29942666, PMID 30349653, PMID 31430616, PMID 32161659, PMID 32172199, PMID 32546198, PMID 32778095, PMID 33992635, PMID 36609248, PMID 37516818, PMID 37563240, PMID 37694493, PMID 37946136, PMID 39530624, PMID 39820336, PMID 39913183, PMID 40552104, PMID 40925003, PMID 41534624
2023 (2), 2016 (1), 2019 (1), 2025 (1)