10 completed, 4 terminated, 1 enrolling by invitation, 1 recruiting. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 10, Terminated 4, Enrolling by invitation 1, Recruiting 1, Withdrawn 1 |
Follow Mucinoses: new trials by email Literature Review of Mucinoses trials Research Report on Mucinoses
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of ELAPRASE in Treatment-naïve Participants With Hunter Syndrome (Mucopolysaccharidosis [MPS] II) ELAPRASE, Rituximab, Methotrexate - Mucopolysaccharidosis (MPS), Hunter Syndrome | Phase 4 | Withdrawn | Takeda | 2023-02-28 | 2025-12-09 | |
| Safety, Tolerability and Efficacy of ICV AX 250 Treatment in MPS IIIB -OLE AX 250 - MPS III B | Phase 4 | Enrolling by invitation | Allievex Corporation | 15 | 2022-12-02 | 2023-08-09 |
| A Study of Elaprase in Children and Adults With Hunter Syndrome (Mucopolysaccharidosis II) in India Elaprase - Hunter Syndrome | Phase 4 | Completed | Takeda | 5 | 2022-04-21 | 2025-01-23 |
| China Post-marketing Surveillance (PMS) Study of Aldurazyme® Laronidase - Mucopolysaccharidosis I | Phase 4 | Completed | Genzyme, a Sanofi Company | 12 | 2021-10-28 | 2025-09-17 |
| Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique Sevoflurane, TIVA - Awareness, Anesthesia, Recall Phenomenon | Phase 4 | Completed | Ain Shams University | 50 | 2021-09-05 | 2022-01-13 |
| Effects of Bisphosphonates on OI-Related Hearing Loss Risedronate Oral Tablet - Osteogenesis Imperfecta | Phase 4 | Recruiting | Hospital for Special Surgery, New York | 100 | 2019-11-02 | 2026-04-28 |
| Long-term Evaluation on Height and Weight in Patients With MPS II Who Started Treatment at < 6 Years of Age Elaprase for intravenous (IV) infusion - Hunter Syndrome | Phase 4 | Completed | Shire | 21 | 2015-10-28 | 2026-04-02 |
| An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst polidocanol, infra-red coagulation, cryotherapy - Ganglion Cysts | Phase 4 | Terminated | University of Edinburgh | 10 | 2015-07-27 | 2024-05-30 |
| Post-operative Analgesia in Elective, Soft-tissue Hand Surgery Acetaminophen/Ibuprofen, Acetaminophen/Hydrocodone - Carpal Tunnel, Ganglion Cyst | Phase 4 | Terminated | Alexander Payatakes, M.D. | 72 | 2015-02-10 | 2018-12-13 |
| A Study of the Effect of Aldurazyme® (Laronidase) Treatment on Lactation in Female Patients With Mucopolysaccharidosis I (MPS I) and Their Breastfed Infants Laronidase - Mucopolysaccharidosis I, Hurler's Syndrome | Phase 4 | Terminated | Genzyme, a Sanofi Company | 2 | 2010-10-22 | 2024-02-20 |
| Pregabalin and Colonic Function Pregabalin, Placebo, Bowel preparation - Healthy | Phase 4 | Completed | Mayo Clinic | 62 | 2010-03-01 | 2012-03-07 |
| Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial curcumin, placebo - Irritable Bowel Syndrome | Phase 4 | Completed | Kaiser Permanente | 17 | 2008-11-01 | 2015-03-11 |
| Safety and Clinical Outcomes in Hunter Syndrome Patients 5 Years of Age and Younger Receiving Idursulfase Therapy Idursulfase - Hunter Syndrome, Mucopolysaccharidosis II | Phase 4 | Completed | Shire | 28 | 2007-12-31 | 2021-06-08 |
| A Phase 4 Two Dose Level Study of Naglazyme(TM) (Galsulfase) in Infants With MPS VI Naglazyme - Mucopolysaccharidosis VI, Maroteaux-Lamy Syndrome | Phase 4 | Completed | BioMarin Pharmaceutical | 4 | 2006-05-01 | 2011-07-22 |
| Morquio's Syndrome: a Case Study physiotherapeutic treatment - Morquio's Disease | Phase 4 | Terminated | Clínica de Hidroterapia e Recuperacao Funcional | 1 | 2006-01-01 | 2008-10-20 |
| A Dose-optimization Study of Aldurazyme® (Laronidase) in Patients With Mucopolysaccharidosis I (MPS I) Disease Aldurazyme (Recombinant Human Alpha-L-Iduronidase) - Mucopolysaccharidosis I, Hurler's Syndrome | Phase 4 | Completed | Genzyme, a Sanofi Company | 34 | 2004-12-01 | 2015-04-03 |
| A Study Investigating the Relationship Between the Development of Laronidase Antibody and Urinary GAG (Glycosaminoglycan) Levels in Aldurazyme® Treated Patients laronidase - Mucopolysaccharidosis I, Hurler's Syndrome | Phase 4 | Completed | Genzyme, a Sanofi Company | 25 | 2004-07-01 | 2014-05-05 |
Mucopolysaccharidosis IV (5) · Mucopolysaccharidosis I (4) · Mucopolysaccharidosis II (4) · Ganglion Cysts (2) · Abdominal Pain (1) · Brittle Bone Disorder (1) · Constipation (1) · De Quervain Disease (1) · Diarrhea (1) · Hearing Loss (1) · Intraoperative Awareness (1) · Irritable Bowel Syndrome (1) · Lysosomal Storage Diseases (1) · Median Neuropathy (1) · Mucopolysaccharidoses (1)
Connective Tissue Diseases (17) · Skin and Connective Tissue Diseases (17) · Carbohydrate Metabolism, Inborn Errors (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (15) · Genetic Diseases, Inborn (15) · Metabolic Diseases (15) · Metabolism, Inborn Errors (15) · Nutritional and Metabolic Diseases (15) · Lysosomal Storage Diseases (14) · Mucopolysaccharidoses (14) · Neurologic Manifestations (7) · Nervous System Diseases (6) · Pathological Conditions, Signs and Symptoms (5) · Genetic Diseases, X-Linked (4)
Iduronidase (4) · idursulfase (4) · Acetaminophen (1) · Cathartics (1) · Cryotherapy (1) · Curcumin (1) · Golytely (1) · Ibuprofen (1) · Immunoglobulins, Intravenous (1) · Methotrexate (1) · Polidocanol (1) · Pregabalin (1) · Risedronic Acid (1) · Rituximab (1) · Sevoflurane (1)
Genzyme, a Sanofi Company (4) · Shire (2) · Takeda (2) · Ain Shams University (1) · Alexander Payatakes, M.D. (1) · Allievex Corporation (1) · BioMarin Pharmaceutical (1) · Clínica de Hidroterapia e Recuperacao Funcional (1) · Hospital for Special Surgery, New York (1) · Kaiser Permanente (1) · Mayo Clinic (1) · University of Edinburgh (1)
United States (9) · Brazil (2) · Germany (2) · United Kingdom (2) · Canada (1) · China (1) · Colombia (1) · Dominican Republic (1) · Egypt (1) · France (1) · India (1) · Italy (1) · Malaysia (1) · Philippines (1) · Poland (1)
Alexander Payatakes, M.D. (1) · Cathleen Raggio, MD (1) · Celeste Decker, MD (1) · Michael Camilleri, MD (1) · Stephen A Holme, MBChB (1)
PMID 21596994, PMID 22393902, PMID 24108527, PMID 25864295, PMID 25902842, PMID 33775523, PMID 41163043
1RC1DK086182 (1), 2014 (1), R01DK067071 (1), R01DK079866 (1), UL1RR024150 (1)