13 completed, 11 terminated, 4 unknown, 3 not yet recruiting. 17 Phase 2, 6 Phase 1, 5 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Metastatic Disease: new trials by email Literature Review of Metastatic Disease trials Research Report on Metastatic Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Symptom Trajectory Approaches to Research Health surveys - Advanced Cancer, Metastatic Disease | Not yet recruiting | University of Wisconsin, Madison | 228 | 2026-12-01 | 2026-09-04 | |
| First-line Treatment in Locally Advanced or Metastastic Small Bowel Adenocarcinoma mFOLFIRINOX versus FOLFOX chemotherapy - Small-bowel Adenocarcinoma, Metastatic Disease | Phase 2 | Not yet recruiting | Annika Kurreck | 86 | 2026-10-01 | 2026-09-28 |
| Study to Evaluate the Efficacy of Zanzalintinib in the Treatment of Relapsed or Metastatic Adenoid Cystic Carcinomas of the Head and Neck Zanzalintinib - Adenoid Cystic Carcinoma of the Salivary Gland, Recurrence | Phase 2 | Not yet recruiting | UNICANCER | 51 | 2026-10-01 | 2026-07-06 |
| Dual-Target CAR-NK Cells Targeting Mesothelin (MSLN) and MUC1 in Advanced Pancreatic Ductal Adenocarcinoma EB-DNK101 dual-targeting CAR-NK cells (MSLN + MUC1), EB-DNK102 dual-targeting CAR-NK cells (CLDN18.2 + MUC1), Lymphodepleting chemotherapy (Flu/Cy) - Pancreatic Ductal Adenocarcinoma (PDAC), Unresectable Locally Advanced | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 42 | 2026-03-02 | 2026-06-04 |
| OLIGO-10: Stereotactic Ablative Radiation Therapy for Metastatic Patients With 6 to 10 Metastatic Sites stereotactic radiation therapy in ablative doses to each metastatic site - Metastatic Disease | Phase 2 | Recruiting | National Medical Research Radiological Centre of the Ministry of Health of Russia | 50 | 2025-02-07 | 2025-03-04 |
| The Role of Surgery for Esophageal Cancer With Metastatic Disease (M1) Esophageal Cancer, Metastatic Disease | Completed | National Taiwan University Hospital | 163 | 2023-02-15 | 2024-05-22 | |
| Abemaciclib for the Treatment of Luminal Metastatic breAst caNcer in the Real-life Clinical pracTice in Russia. Abemaciclib - HR+/HER2- Breast Cancer, Metastatic Disease | Completed | Blokhin's Russian Cancer Research Center | 136 | 2022-04-01 | 2023-03-31 | |
| MAnagement of METastatic Disease in Campania (MAMETIC) 3DCRT, IMRT, VMAT, SBRT - Metastatic Disease | Completed | National Cancer Institute, Naples | 3234 | 2020-09-11 | 2024-11-07 | |
| Analysis of Next Generation PET and Liquid Biopsy to Monitor mCRPC Treated With Abiraterone: ANGELA Trial Abiraterone, Prednisone, Androgen deprivation therapy - Prostate Cancer, Castration-resistant Prostate Cancer | Unknown | Fudan University | 30 | 2020-07-15 | 2022-01-12 | |
| The Use of Indocyanine Green as a Diagnostic Adjunct for Pediatric Solid Malignancies Metastatic Disease, Primary Tumor | Unknown | Roshni Dasgupta | 45 | 2020-06-05 | 2020-07-30 | |
| Safety and Targeting of Anti-hk2 Antibody in mCRPC 111In-DOTA-h11B6 - Castration-Resistant Prostatic Cancer, Metastatic Disease | Early Phase 1 | Terminated | SpectronRX | 27 | 2019-09-18 | 2023-09-25 |
| IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study Darleukin, Radiation - NSCLC Stage IV, Metastatic Disease | Phase 2 | Terminated | Maastricht University Medical Center | 88 | 2019-04-04 | 2025-01-30 |
| Intravenously Administered Liposomal PROMITIL in Combination With External Beam Radiotherapy in Cancer Patients Promitil, EBR - Cancer, Solid Tumor | Phase 1 | Completed | Lipomedix Pharmaceuticals Inc. | 18 | 2019-01-03 | 2022-01-06 |
| Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery Vacuum Assisted Closure, Sterile dressing - Metastatic Disease, Spinal Cord Injury | Not applicable | Unknown | John Street | 550 | 2017-03-18 | 2018-08-15 |
| Modified Melanoma Vaccine for High Risk or Low Residual Disease Patients Melanoma vaccine modified to express HLA A2/4-1BB ligand - High Risk HLA-A2+ Melanoma, Metastatic Disease | Phase 2 / Phase 3 | Withdrawn | Hadassah Medical Organization | 2017-03-01 | 2025-10-02 | |
| Nintedanib Plus mFOLFOX6 for Previously Untreated Metastatic Esophagogastric Adenocarcinoma (MEGAN) Nintedanib, Fluorouracil, Leucovorin - Esophagogastric Adenocarcinoma, Metastatic Disease | Phase 2 | Withdrawn | European Organisation for Research and Treatment of Cancer - EORTC | 2016-12-01 | 2017-05-09 | |
| Study of the Pan-DAC Inhibitor AR-42 and Pazopanib in Advanced Sarcoma and Kidney Cancer AR-42, Pazopanib - Renal Cell Carcinoma, Soft Tissue Sarcoma | Phase 1 | Terminated | Virginia Commonwealth University | 6 | 2016-07-08 | 2019-10-24 |
| Outcomes of FoundationOne Directed Therapy in Cancer of Unknown Primary Neoplasms, Unknown Primary, CUP | Completed | Foundation Medicine | 125 | 2015-05-01 | 2018-07-10 | |
| A Study of Hypoxia Imaging in Advanced Pancreatic Cancer Patients Being Treated With Gemcitabine and TH-302 or TH-302 Placebo 18F-Fluoroazomycin arabinoside - Pancreatic Adenocarcinoma, Advanced Disease | Not applicable | Withdrawn | University Health Network, Toronto | 2014-11-01 | 2018-02-19 | |
| Regorafenib as Single Agent in Patients With Metastatic Colorectal Cancer (mCRC) With Any RAS or BRAF Mutation Previously Treated With FOLFOXIRI Plus Bevacizumab Regorafenib - Colorectal Neoplasms, Metastatic Disease | Phase 2 | Terminated | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | 15 | 2014-06-01 | 2017-08-01 |
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Neoplasm Metastasis (36) · Carcinoma, Renal Cell (3) · Prostatic Neoplasms (3) · Colorectal Neoplasms (2) · Melanoma (2) · Pancreatic Neoplasms (2) · Recurrence (2) · Sarcoma (2) · Astrocytoma (1) · Biliary Tract Neoplasms (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Cancer Pain (1) · Carcinoma, Non-Small-Cell Lung (1) · Choroid Plexus Neoplasms (1)
Neoplastic Processes (36) · Pathologic Processes (36) · Pathological Conditions, Signs and Symptoms (36) · Neoplasms (35) · Neoplasms by Site (19) · Digestive System Diseases (7) · Digestive System Neoplasms (7) · Male Urogenital Diseases (7) · Neoplasms by Histologic Type (7) · Urogenital Diseases (7) · Urogenital Neoplasms (7) · Gastrointestinal Diseases (4) · Gastrointestinal Neoplasms (4) · Genital Diseases (4) · Genital Diseases, Male (4)
Radiosurgery (3) · Sorafenib (3) · Cisplatin (2) · Fluorouracil (2) · Gemcitabine (2) · Oxaliplatin (2) · Radiotherapy, Intensity-Modulated (2) · regorafenib (2) · 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide (1) · Afatinib (1) · Androgen Antagonists (1) · Capecitabine (1) · Cetuximab (1) · Cyclophosphamide (1) · Dasatinib (1)
University Health Network, Toronto (3) · Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) (2) · Annika Kurreck (1) · Beijing Biotech (1) · Blokhin's Russian Cancer Research Center (1) · Centro Nacional de Investigaciones Oncologicas CARLOS III (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Foundation CPCT (1) · Foundation Medicine (1) · Fox Chase Cancer Center (1) · Fudan University (1) · Hadassah Medical Organization (1) · Italian Trial in Medical Oncology (1) · Johannes Gutenberg University Mainz (1) · John Street (1)
United States (11) · Germany (4) · Canada (3) · Italy (3) · Netherlands (3) · Spain (3) · China (2) · France (2) · Russia (2) · Belgium (1) · Israel (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
A. Ardizzoia, MD (1) · A. Bertolini, MD (1) · Adi Levy, MD (1) · Alfredo Carrato, MD-PhD (1) · Andrew S Poklepovic, MD (1) · Andrey Kaprin, PhD (1) · Annika Kurreck, PD Dr. (1) · Antonio Finelli, MD,MSc,FRCSC (1) · C. Porta, MD (1) · D. Amadori, MD (1) · Dr. Sandy Srinivas (1) · E. Aitini, MD (1) · Eli Sapir, MD (1)
PMID 12459649, PMID 24063860, PMID 30120161, PMID 30634942, PMID 32539805, PMID 33495476, PMID 33688020, PMID 33964451, PMID 35086719, PMID 35422656, PMID 37146227, PMID 37400554, PMID 37968696, PMID 38300729, PMID 38782459, PMID 39151419, PMID 40114169
2014 (1), 2016 (1), P30CA016059 (1), R01CA307143 (1), U10CA081851 (1)