15 recruiting, 12 active not recruiting, 11 completed, 3 not yet recruiting. 25 Phase 1, 18 Phase 2, 5 Not applicable, 2 Phase 3, 1 Phase 4.
Follow Metastatic Colorectal Carcinoma: new trials by email Literature Review of Metastatic Colorectal Carcinoma trials Research Report on Metastatic Colorectal Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-12-01 | 2026-10-05 |
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| A Clinical Trial of LBL-024 Combination Drug in Patients With Metastatic Colorectal Carcinoma LBL-024 for Injection, Bevacizumab injection, Oxaliplatin injection - Metastatic Colorectal Carcinoma | Phase 1 / Phase 2 | Recruiting | Nanjing Leads Biolabs Co.,Ltd | 369 | 2026-09-28 | 2026-10-16 |
| STIL101 for Injection for the Treatment of Locally Advanced, Metastatic or Unresectable Pancreatic Cancer, Colorectal Cancer, Renal Cell Cancer, Cervical Cancer and Melanoma Aldesleukin, Biopsy, Biospecimen Collection - Locally Advanced Cervical Carcinoma, Locally Advanced Colorectal Carcinoma | Phase 1 | Withdrawn | City of Hope Medical Center | 2025-12-05 | 2025-12-24 | |
| Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Peritoneum | Phase 1 | Active not recruiting | Arjun Mittra | 9 | 2024-12-31 | 2026-10-09 |
| A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours FPI-2053, [111In]-FPI-2107, [225Ac]-FPI-2068 - Advanced Solid Tumor, Metastatic Colorectal Carcinoma | Phase 1 | Active not recruiting | AstraZeneca | 13 | 2024-07-31 | 2026-09-30 |
| Local Liver Treatment for Multi-organ Colorectal Cancer Metastases Radical local Surgery, Systemic therapy, Interventional therapy - Metastatic Colorectal Carcinoma, Multi-organ Metastatic Colorectal Cancer | Not applicable | Recruiting | Anhui Provincial Hospital | 130 | 2024-07-01 | 2024-06-10 |
| Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program Home Health Encounter, Nivolumab, Patient Monitoring - Advanced Esophageal Squamous Cell Carcinoma, Advanced Renal Cell Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 50 | 2024-04-30 | 2026-10-02 |
| Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform Biospecimen Collection, Tissue Collection - Early Stage Triple-Negative Breast Carcinoma, Metastatic Bladder Urothelial Carcinoma | Recruiting | Mayo Clinic | 324 | 2024-04-24 | 2026-03-12 | |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer Pentoxifylline, FOLFOX, XELOX - Metastatic Colorectal Carcinoma | Phase 4 | Completed | Tanta University | 44 | 2024-02-01 | 2026-10-21 |
| Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Carcinoma, Metastatic Malignant Solid Neoplasm | Phase 1 | Recruiting | National Cancer Institute (NCI) | 30 | 2023-11-08 | 2026-09-29 |
| CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors Biospecimen Collection, Computed Tomography, Devimistat - Advanced Biliary Tract Carcinoma, Advanced Colorectal Carcinoma | Phase 2 | Recruiting | Northwestern University | 94 | 2023-03-08 | 2023-03-10 |
| First-in-human Phase I Study to Evaluate Safety, Tolerability and Antineoplastic Activity of OATD-02 in Patients With Selected Advanced and/or Metastatic Solid Tumours OATD-02 - Advanced Ovarian Carcinoma, Advanced Renal Cell Carcinoma | Phase 1 | Recruiting | Molecure S.A. | 40 | 2023-01-26 | 2026-07-31 |
| BXQ-350 in Newly Diagnosed Metastatic Colorectal Carcinoma BXQ-350, Placebo - Metastatic Colorectal Carcinoma, Neuropathy | Phase 1 / Phase 2 | Active not recruiting | Bexion Pharmaceuticals, Inc. | 195 | 2023-01-09 | 2026-09-29 |
| A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer Colorectal Cancer Peptide Vaccine PolyPEPI1018, Trifluridine and Tipiracil Hydrochloride - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Completed | Mayo Clinic | 15 | 2022-01-10 | 2026-10-07 |
| Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC) Pixatimod, Nivolumab, Cyclophosphamide (low dose) - NSCLC, Metastatic Colorectal Carcinoma | Phase 2 | Completed | Diwakar Davar | 13 | 2021-12-09 | 2026-09-08 |
| Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines Biopsy Procedure, Biospecimen Collection, Diagnostic Imaging Testing - Advanced Colorectal Carcinoma, Advanced Digestive System Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 10 | 2021-08-13 | 2026-08-21 |
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Colorectal Neoplasms (49) · Colonic Neoplasms (9) · Neoplasm Metastasis (9) · Carcinoma, Renal Cell (8) · Stomach Neoplasms (8) · Rectal Neoplasms (7) · Carcinoma, Non-Small-Cell Lung (6) · Melanoma (6) · Pancreatic Neoplasms (6) · Esophageal Neoplasms (5) · Carcinoma, Hepatocellular (4) · Carcinoma, Transitional Cell (4) · Lung Neoplasms (4) · Ovarian Neoplasms (4) · Sarcoma (4)
Colonic Diseases (49) · Digestive System Diseases (49) · Digestive System Neoplasms (49) · Gastrointestinal Diseases (49) · Intestinal Diseases (49) · Intestinal Neoplasms (49) · Neoplasms (49) · Neoplasms by Site (49) · Rectal Diseases (49) · Gastrointestinal Neoplasms (47) · Neoplasms by Histologic Type (15) · Adenocarcinoma (12) · Carcinoma (12) · Neoplasms, Glandular and Epithelial (12) · Female Urogenital Diseases (11)
Specimen Handling (13) · Magnetic Resonance Spectroscopy (11) · Biopsy (10) · Fluorouracil (9) · dehydroftorafur (9) · Bevacizumab (7) · Leucovorin (7) · Oxaliplatin (7) · Disulfides (6) · Immunoglobulin G (6) · Irinotecan (6) · Nivolumab (5) · Trifluridine (5) · trifluridine tipiracil drug combination (5) · Capecitabine (4)
M.D. Anderson Cancer Center (8) · City of Hope Medical Center (7) · National Cancer Institute (NCI) (6) · Academic and Community Cancer Research United (5) · Mayo Clinic (5) · Anhui Provincial Hospital (1) · Anne Noonan (1) · Arjun Mittra (1) · AstraZeneca (1) · Bexion Pharmaceuticals, Inc. (1) · Diwakar Davar (1) · ECOG-ACRIN Cancer Research Group (1) · Fred Hutchinson Cancer Center (1) · Molecure S.A. (1) · Nanjing Leads Biolabs Co.,Ltd (1)
United States (42) · Canada (4) · China (2) · Austria (1) · Egypt (1) · Germany (1) · Poland (1) · Spain (1) · Uganda (1)
Liza C Villaruz (2) · Marwan G Fakih (2) · Alisha Bent, MD (1) · Anne M Noonan, MBBChBAO, MSc (1) · Anwaar Saeed (1) · Arjun Mittra, MD (1) · Barry Smith, M.D., Ph.D. (1) · Christine M Parseghian, MD (1) · Dalia Refaat, Assistant Professor (1) · David S Hong (1) · Dev Mukhopadhyay, PhD (1) · Devalingam Mahalingam (1) · Diwakar Davar, MD (1) · Emmanuel M Gabriel, M.D., Ph.D. (1)
PMID 12001988, PMID 17704903, PMID 19906081, PMID 19917863, PMID 20061178, PMID 20233873, PMID 20336386, PMID 20374484, PMID 20490982, PMID 20737573, PMID 21153378, PMID 21909917, PMID 21926464, PMID 22162570, PMID 23456602, PMID 24956510, PMID 25013744, PMID 26883450, PMID 2801858, PMID 33142018, PMID 33654117, PMID 35033226, PMID 35179586, PMID 35264434, PMID 35738999, PMID 36634920, PMID 36892833, PMID 37124504, PMID 3808620, PMID 38236249, PMID 39841295, PMID 40377420, PMID 40515475, PMID 40791544, PMID 41484629
P30CA015083 (5), P30CA033572 (5), UM1CA186690 (3), UM1CA186709 (2), P30CA016672 (1), P30CA060553 (1), P30CA072720 (1), R01CA187238 (1), R01DK140085 (1), R21CA282536 (1), U01CA062490 (1), U10CA180820 (1), UM1CA186644 (1), UM1CA186688 (1), UM1CA186689 (1)