11 recruiting, 7 active not recruiting, 6 completed, 4 withdrawn. 32 Phase 2, 5 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 32 | Recruiting 11, Active not recruiting 7, Completed 6, Withdrawn 4, Terminated 3, Unknown 1 |
| Phase 1 | 5 | Terminated 2, Withdrawn 2, Recruiting 1 |
| Phase 3 | 1 | Completed 1 |
Follow Metastatic Breast Carcinoma: new trials by email Literature Review of Metastatic Breast Carcinoma trials Research Report on Metastatic Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 177Lu-DOTATATE for the Treatment of Stage IV or Recurrent Breast Cancer Biopsy, Biospecimen Collection, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 10 | 2026-06-30 | 2026-06-05 |
| [18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer Best Practice, Biopsy of Breast, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 / Phase 2 | Recruiting | University of Washington | 22 | 2026-02-26 | 2026-05-19 |
| Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer Biopsy, Biospecimen Collection, Cemiplimab - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 11 | 2026-01-30 | 2026-05-20 |
| Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial Biospecimen Collection, Electronic Health Record Review, Goserelin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 75 | 2026-01-22 | 2026-06-23 |
| Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2025-05-05 | 2025-12-08 |
| Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | University of Washington | 22 | 2025-03-03 | 2026-08-14 |
| Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor-Positive Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 18 | 2024-07-23 | 2026-10-07 |
| Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel Paclitaxel, Monosialotetrahexosylganglioside, Questionnaire Administration - Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy | Phase 2 | Active not recruiting | Alliance for Clinical Trials in Oncology | 7 | 2023-11-02 | 2026-10-19 |
| A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer Stereotactic body radiotherapy - Oligometastatic Breast Carcinoma, Breast Cancer | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 46 | 2022-09-06 | 2026-10-02 |
| Radioembolization of Metastatic Breast Cancer to the Liver as a 2nd/3rd Line Therapy Y-90 SIR-Spheres, Yttrium-90 Microsphere Radioembolization, Systemic Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Withdrawn | Emory University | 2022-08-17 | 2024-01-19 | |
| Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer Copanlisib, Pertuzumab, Trastuzumab - Anatomic Stage IV Breast Cancer AJCC v8, HER2-Positive Breast Carcinoma | Phase 1 / Phase 2 | Terminated | National Cancer Institute (NCI) | 2 | 2021-05-20 | 2025-10-01 |
| Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations Biopsy Procedure, Biospecimen Collection, Computed Tomography - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 29 | 2021-04-26 | 2026-08-19 |
| Breast Cancer Vaccine in Combination With Pembrolizumab for Treatment of Persistent, Recurrent, or Metastatic Breast Cancer Cyclophosphamide, Allogeneic GM-CSF-secreting Breast Cancer Vaccine SV-BR-1-GM, Pembrolizumab - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 / Phase 2 | Withdrawn | Thomas Jefferson University | 2020-12-21 | 2025-04-29 | |
| T-DM1 With or Without Abemaciclib for the Treatment of HER2-Positive Metastatic Breast Cancer Abemaciclib, Trastuzumab Emtansine - Anatomic Stage IV Breast Cancer AJCC v8, HER2 Positive Breast Carcinoma | Phase 2 | Withdrawn | Academic and Community Cancer Research United | 2020-11-11 | 2022-05-26 | |
| Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study Computed Tomography, Fludeoxyglucose F-18, Positron Emission Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Carcinoma | Phase 2 | Active not recruiting | ECOG-ACRIN Cancer Research Group | 138 | 2020-09-15 | 2026-10-19 |
| Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer Cediranib, Ceralasertib, Olaparib - Advanced Breast Carcinoma, Anatomic Stage III Breast Cancer AJCC v8 | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 60 | 2020-07-28 | 2026-09-14 |
| Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer. Abemaciclib, Questionnaire Administration - Anatomic Stage IV Breast Cancer AJCC v8, Hormone Receptor Positive Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 43 | 2020-06-05 | 2026-10-16 |
| Aromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Cancer With an ERS1 Activating Mutation, the INTERACT Study Abemaciclib, Anastrozole, Fulvestrant - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Terminated | M.D. Anderson Cancer Center | 4 | 2019-05-31 | 2024-12-27 |
| Repeatability of 68-GaNOTA-Anti-HER2 VHH1 PET/CT in Breast Carcinoma Patients 68GaNOTA-Anti-HER2 VHH1 - Metastatic Breast Carcinoma, Locally Advanced Breast Cancer | Phase 2 | Unknown | Universitair Ziekenhuis Brussel | 55 | 2019-04-01 | 2024-02-16 |
| A Study of a New Drug Combination, Copanlisib and Fulvestrant, in Advanced Breast Cancer Copanlisib, Fulvestrant - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 / Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2019-02-13 | 2023-09-25 |
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Breast Neoplasms (32) · Carcinoma, Non-Small-Cell Lung (3) · Pancreatic Neoplasms (3) · Brain Neoplasms (2) · Colorectal Neoplasms (2) · Endometrial Neoplasms (2) · Lung Neoplasms (2) · Meningeal Carcinomatosis (2) · Ovarian Neoplasms (2) · Prostatic Neoplasms (2) · Stomach Neoplasms (2) · Biliary Tract Neoplasms (1) · Carcinoma, Transitional Cell (1) · Cholangiocarcinoma (1) · Inflammatory Breast Neoplasms (1)
Breast Diseases (32) · Neoplasms (32) · Neoplasms by Site (32) · Skin Diseases (32) · Skin and Connective Tissue Diseases (32) · Central Nervous System Neoplasms (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Bronchial Neoplasms (3) · Carcinoma, Bronchogenic (3) · Digestive System Diseases (3) · Digestive System Neoplasms (3) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Female Urogenital Diseases (3)
Magnetic Resonance Spectroscopy (10) · Specimen Handling (9) · Biopsy (5) · Cyclophosphamide (5) · Fulvestrant (5) · Letrozole (3) · Radiosurgery (3) · Taxes (3) · abemaciclib (3) · palbociclib (3) · pembrolizumab (3) · 2C4 antibody (2) · Anastrozole (2) · Carboplatin (2) · Fluorodeoxyglucose F18 (2)
National Cancer Institute (NCI) (8) · City of Hope Medical Center (6) · M.D. Anderson Cancer Center (4) · Emory University (2) · University of Washington (2) · Academic and Community Cancer Research United (1) · Alliance for Clinical Trials in Oncology (1) · ECOG-ACRIN Cancer Research Group (1) · Haukeland University Hospital (1) · Memorial Sloan Kettering Cancer Center (1) · NRG Oncology (1) · OHSU Knight Cancer Institute (1) · Thomas Jefferson University (1) · Universitair Ziekenhuis Brussel (1) · University of Michigan Rogel Cancer Center (1)
United States (30) · Canada (2) · Puerto Rico (2) · Belgium (1) · Ireland (1) · Norway (1) · Saudi Arabia (1) · South Korea (1)
Joanne Mortimer (2) · A P Chen (1) · Amy Xu, MD, PhD (1) · Banu Arun (1) · Ciara C O'Sullivan (1) · Elizabeth C Dees (1) · Eve T Rodler (1) · Hans Petter Eikesdal, MD PhD (1) · Jennifer M Specht (1) · Jennifer Specht, MD (1) · Joanne Mortimer, MD (1) · Jonathan Kessler (1) · Jose G Bazan (1) · Kerin B Adelson (1) · Lia M. Halasz (1)
PMID 24812403, PMID 30714987, PMID 33084020, PMID 33757987, PMID 34217908, PMID 35104158, PMID 35602670, PMID 36008574, PMID 36269154, PMID 36623515, PMID 38816232, PMID 40169866, PMID 41116969
P30CA033572 (7), 2016 (2), N01CM00099 (2), P30CA138292 (2), UM1CA186688 (2), N01CM00032 (1), N01CM00038 (1), N01CM00039 (1), N01CM00070 (1), N01CM00071 (1), N01CM62201 (1), N01CM62202 (1), N01CM62203 (1), N01CM62204 (1), N01CM62207 (1)