23 recruiting, 18 active not recruiting, 15 completed, 10 withdrawn. 32 Phase 2, 25 Phase 1, 9 Not applicable, 4 Phase 3, 2 Early Phase 1.
Follow Metastatic Breast Carcinoma: new trials by email Literature Review of Metastatic Breast Carcinoma trials Research Report on Metastatic Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer Biopsy Procedure, Biospecimen Collection, Echocardiography Test - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 36 | 2026-10-06 | 2026-10-16 |
| Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 | Withdrawn | National Cancer Institute (NCI) | 2026-10-01 | 2026-08-28 | |
| 177Lu-DOTATATE for the Treatment of Stage IV or Recurrent Breast Cancer Biopsy, Biospecimen Collection, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 10 | 2026-06-30 | 2026-06-05 |
| [18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer Best Practice, Biopsy of Breast, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 1 / Phase 2 | Recruiting | University of Washington | 22 | 2026-02-26 | 2026-05-19 |
| Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer Biopsy, Biospecimen Collection, Cemiplimab - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 11 | 2026-01-30 | 2026-05-20 |
| Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial Biospecimen Collection, Electronic Health Record Review, Goserelin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | University of Michigan Rogel Cancer Center | 75 | 2026-01-22 | 2026-06-23 |
| Living Well With Advanced Breast Cancer Non-Interventional Study - Advanced Breast Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-01-13 | 2026-03-19 | |
| Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Craniospinal Irradiation, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 35 | 2025-05-05 | 2025-12-08 |
| Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial Biospecimen Collection, Computed Tomography, Involved-Field Radiation Therapy - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Recruiting | NRG Oncology | 115 | 2025-03-04 | 2026-08-17 |
| Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 2 | Recruiting | University of Washington | 22 | 2025-03-03 | 2026-08-14 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| MBC Physical Activity Study Exercise Intervention, Health Promotion and Education, Internet-Based Intervention - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Completed | Thomas Jefferson University | 12 | 2024-09-06 | 2025-11-21 |
| A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer 18F-Fluoroestradiol PET/CT - Breast Cancer, Lobular Breast Carcinoma | Active not recruiting | Memorial Sloan Kettering Cancer Center | 7 | 2024-08-13 | 2026-07-14 | |
| Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer Biospecimen Collection, Bone Scan, Computed Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor-Positive Breast Carcinoma | Phase 2 | Recruiting | City of Hope Medical Center | 18 | 2024-07-23 | 2026-10-07 |
| Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against Cancer Non-Interventional Study - Anatomic Stage IV Breast Cancer AJCC v8, Glioblastoma | Recruiting | City of Hope Medical Center | 160 | 2024-07-05 | 2026-06-24 | |
| DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients Biospecimen Collection - HER2-negative Breast Cancer, Hormone-receptor-positive Breast Cancer | Recruiting | Mayo Clinic | 100 | 2024-04-30 | 2026-06-01 | |
| An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer Behavioral Dietary Intervention, Text Message-Based Navigation Intervention, Internet-Based Intervention - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Terminated | Thomas Jefferson University | 1 | 2023-12-13 | 2026-03-03 |
| Finding an Effective Dose of GM1 to Reduce or Prevent Neuropathy (Numbness or Weakness) Due to Treatment With Paclitaxel Paclitaxel, Monosialotetrahexosylganglioside, Questionnaire Administration - Anatomic Stage IV Breast Cancer AJCC v8, Chemotherapy-Induced Peripheral Neuropathy | Phase 2 | Active not recruiting | Alliance for Clinical Trials in Oncology | 7 | 2023-11-02 | 2026-10-19 |
| A Study of 1 8F-FDHT PET/MRIScans in Women With Breast Cancer 18F-FDG PET/CT, [18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone PET Imaging, 18F-FDHT - Breast Cancer, Breast Carcinoma | Early Phase 1 | Withdrawn | Memorial Sloan Kettering Cancer Center | 2023-10-24 | 2025-05-18 | |
| Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors Abemaciclib, BET Bromodomain Inhibitor ZEN-3694, Biopsy Procedure - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 45 | 2023-08-10 | 2026-07-31 |
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Breast Neoplasms (79) · Lung Neoplasms (11) · Neoplasm Metastasis (11) · Brain Neoplasms (8) · Carcinoma, Non-Small-Cell Lung (7) · Ovarian Neoplasms (6) · Pancreatic Neoplasms (6) · Prostatic Neoplasms (6) · Triple Negative Breast Neoplasms (5) · Colorectal Neoplasms (4) · Endometrial Neoplasms (4) · Meningeal Carcinomatosis (4) · Stomach Neoplasms (4) · Carcinoma, Renal Cell (3) · Fallopian Tube Neoplasms (3)
Breast Diseases (79) · Neoplasms by Site (79) · Skin Diseases (79) · Skin and Connective Tissue Diseases (79) · Neoplasms (78) · Pathological Conditions, Signs and Symptoms (14) · Urogenital Diseases (14) · Neoplasms by Histologic Type (13) · Neoplastic Processes (13) · Pathologic Processes (13) · Urogenital Neoplasms (13) · Central Nervous System Neoplasms (12) · Genital Diseases (12) · Lung Diseases (12) · Nervous System Diseases (12)
Magnetic Resonance Spectroscopy (21) · Specimen Handling (21) · Biopsy (11) · Fulvestrant (7) · abemaciclib (7) · Cyclophosphamide (6) · Taxes (6) · palbociclib (6) · pembrolizumab (6) · Ogivri (5) · Ontruzant (5) · PF-05280014 (5) · Radiosurgery (5) · Trastuzumab (5) · X-Rays (5)
National Cancer Institute (NCI) (17) · City of Hope Medical Center (9) · M.D. Anderson Cancer Center (8) · Mayo Clinic (8) · Thomas Jefferson University (4) · Emory University (3) · Memorial Sloan Kettering Cancer Center (3) · NRG Oncology (3) · University of Washington (3) · OHSU Knight Cancer Institute (2) · Ohio State University Comprehensive Cancer Center (2) · Roswell Park Cancer Institute (2) · University of Southern California (2) · Academic and Community Cancer Research United (1) · Alliance for Clinical Trials in Oncology (1)
United States (70) · Canada (3) · Ireland (2) · Puerto Rico (2) · Belgium (1) · France (1) · Hong Kong (1) · Norway (1) · Saudi Arabia (1) · South Africa (1) · South Korea (1)
Joanne Mortimer (2) · Meghan Karuturi (2) · A P Chen (1) · Agnieszka K Witkiewicz (1) · Alison M Schram (1) · Amy Xu, MD, PhD (1) · Apostolia M Tsimberidou (1) · Ashley P Davenport, MD (1) · Banu Arun (1) · Brenda J. Ernst, M.D. (1) · Ciara C O'Sullivan (1) · Ciara O'Sullivan, M.B., B.Ch. (1) · Cynthia X Ma (1) · Daniel G Stover, MD (1) · Dubuc Myriam (1)
PMID 12001988, PMID 17704903, PMID 19906081, PMID 19917863, PMID 20061178, PMID 20233873, PMID 20336386, PMID 20374484, PMID 20490982, PMID 20737573, PMID 21153378, PMID 21909917, PMID 21926464, PMID 22162570, PMID 23456602, PMID 24812403, PMID 24956510, PMID 25013744, PMID 26883450, PMID 2801858, PMID 30714987, PMID 33084020, PMID 33654117, PMID 33757987, PMID 34217908, PMID 34357781, PMID 35104158, PMID 35602670, PMID 36008574, PMID 36269154, PMID 36351402, PMID 36623515, PMID 37103597, PMID 37124504, PMID 37704753, PMID 3808620, PMID 38106014, PMID 38152697, PMID 38816232, PMID 39863139, PMID 40169866, PMID 40506447, PMID 40939237, PMID 41116969, PMID 41576303, PMID 42868120
P30CA033572 (10), P30CA138292 (3), U10CA180868 (3), UM1CA186688 (3), UM1CA186709 (3), 2016 (2), N01CM00099 (2), N01CM62204 (2), P30CA013330 (2), U10CA180820 (2), UM1CA186689 (2), UM1CA186691 (2), UM1CA186704 (2), UM1CA186712 (2), N01CM00032 (1)