32 completed. 32 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 32 | Completed 32 |
Follow Menorrhagia: new trials by email Literature Review of Menorrhagia trials Research Report on Menorrhagia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of a Levonorgestrel 52 mg Intrauterine System for the Treatment of Heavy Menstrual Bleeding Levonorgestrel 52 mg intrauterine system - Menorrhagia | Phase 3 | Completed | Medicines360 | 105 | 2019-01-17 | 2024-05-14 |
| Study of Relugolix With Estradiol and Norethindrone Acetate in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Relugolix, Estradiol/norethindrone acetate, Placebo for relugolix - Uterine Leiomyoma, Uterine Fibroids | Phase 3 | Completed | Myovant Sciences GmbH | 229 | 2018-10-16 | 2024-06-25 |
| Treatment of Heavy and/or Prolonged Menstrual Bleeding Without Organic Cause combined contraceptive pills (microcept), medroxyprogesterone acetate (progest), mefenamic acid (ponstan forte) - Improve Quality of Life, Heavy Menstrual Bleeding | Phase 3 | Completed | Assiut University | 240 | 2017-11-01 | 2021-06-04 |
| LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Relugolix, Estradiol/norethindrone acetate - Heavy Menstrual Bleeding, Uterine Fibroid | Phase 3 | Completed | Myovant Sciences GmbH | 477 | 2017-10-19 | 2024-05-09 |
| Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Estradiol /norethindrone acetate (E2/NETA), E2/NETA Placebo - Heavy Menstrual Bleeding, Uterine Fibroids | Phase 3 | Completed | AbbVie | 478 | 2017-09-13 | 2025-07-22 |
| LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Relugolix, Estradiol/norethindrone acetate, Relugolix placebo - Heavy Menstrual Bleeding, Uterine Fibroid | Phase 3 | Completed | Myovant Sciences GmbH | 382 | 2017-06-14 | 2022-04-20 |
| Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids OBE2109, Placebo to match OBE2109, Placebo to match Add-back - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | ObsEva SA | 511 | 2017-05-23 | 2021-03-05 |
| LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Relugolix, Estradiol/norethindrone acetate, Estradiol/norethindrone acetate placebo - Heavy Menstrual Bleeding, Uterine Fibroid | Phase 3 | Completed | Myovant Sciences GmbH | 388 | 2017-04-26 | 2022-04-19 |
| Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids OBE2109, Placebo to match OBE2109, Placebo to match Add-back - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | ObsEva SA | 526 | 2017-04-20 | 2021-06-09 |
| Mirena Extension Trial Levonorgestrel IUS (Mirena, BAY86-5028) - Contraception | Phase 3 | Completed | Bayer | 364 | 2016-12-22 | 2022-04-28 |
| An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids Estradiol/Norethindrone Acetate, Elagolix - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 433 | 2016-09-14 | 2021-07-13 |
| Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study) Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 378 | 2016-02-03 | 2021-07-13 |
| Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women Elagolix, Placebo for Estradiol/Norethindrone Acetate, Estradiol/Norethindrone Acetate - Uterine Fibroids, Heavy Menstrual Bleeding | Phase 3 | Completed | AbbVie | 413 | 2015-12-22 | 2020-06-29 |
| Study of a 4-phasic Oral Contraceptive for the Treatment of Heavy Menstrual Bleeding EV/DNG (Qlaira, Natazia, BAY86-5027), placebo - Metrorrhagia | Phase 3 | Completed | Bayer | 339 | 2012-06-01 | 2015-07-10 |
| Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual Bleeding Levosert-20, Mirena - Heavy Menstrual Bleeding | Phase 3 | Completed | Uteron Pharma S.A. | 280 | 2007-12-01 | 2012-09-28 |
| A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding Tranexamic acid - Menorrhagia | Phase 3 | Completed | Ferring Pharmaceuticals | 288 | 2007-04-01 | 2011-07-26 |
| Efficacy and Safety of XP12B in Women With Menorrhagia Tranexamic acid tablets, Placebo tablets - Menorrhagia, Heavy Menstrual Bleeding | Phase 3 | Completed | Ferring Pharmaceuticals | 304 | 2006-11-01 | 2015-05-13 |
| Efficacy and Safety Study of XP12B in Women With Menorrhagia Tranexamic acid tablets, Placebo tablets - Menorrhagia, Heavy Menstrual Bleeding | Phase 3 | Completed | Ferring Pharmaceuticals | 196 | 2006-10-01 | 2011-05-04 |
| Study in Women With Idiopathic Menorrhagia to Determine the Reduction in Menstrual Blood Loss (MBL) After Treatment With the Levonorgestrel-releasing Intrauterine System (IUS) Levonorgestrel IUS (Mirena, BAY86-5028), Medroxyprogesterone acetate - Menorrhagia | Phase 3 | Completed | Bayer | 165 | 2006-07-01 | 2013-12-09 |
| Comparison of Two Hysteroscopy Approaches vaginoscopic hysteroscopy - Menorrhagia | Phase 3 | Completed | Wolfson Medical Center | 130 | 2005-07-01 | 2006-11-28 |
Showing 20 of 32. Sign in to see all of them.
Leiomyoma (17) · Metrorrhagia (8) · Uterine Hemorrhage (7) · Anemia (1) · Myofibroma (1) · Uterine Neoplasms (1)
Female Urogenital Diseases (32) · Female Urogenital Diseases and Pregnancy Complications (32) · Genital Diseases (32) · Genital Diseases, Female (32) · Hemorrhage (32) · Menstruation Disturbances (32) · Pathologic Processes (32) · Pathological Conditions, Signs and Symptoms (32) · Urogenital Diseases (32) · Uterine Diseases (32) · Uterine Hemorrhage (25) · Neoplasms (17) · Neoplasms by Histologic Type (17) · Neoplasms, Connective and Soft Tissue (17) · Neoplasms, Muscle Tissue (17)
estradiol, norethindrone drug combination (7) · asoprisnil (6) · Estradiol (5) · Levonorgestrel (5) · Tranexamic Acid (4) · elagolix (4) · relugolix (4) · Hysterectomy (3) · Norethindrone Acetate (3) · Medroxyprogesterone Acetate (2) · linzagolix (2) · Endometrial Ablation Techniques (1) · Iron (1) · Iron-Dextran Complex (1) · Mefenamic Acid (1)
Abbott (6) · AbbVie (4) · Ferring Pharmaceuticals (4) · Myovant Sciences GmbH (4) · Bayer (3) · ObsEva SA (2) · Agency for Healthcare Research and Quality (AHRQ) (1) · American Regent, Inc. (1) · Assiut University (1) · Ethicon, Inc. (1) · Medicines360 (1) · University of Helsinki (1) · Uteron Pharma S.A. (1) · Wolfson Medical Center (1) · ZonMw: The Netherlands Organisation for Health Research and Development (1)
United States (18) · Brazil (5) · Poland (5) · Canada (4) · Czechia (4) · Hungary (4) · South Africa (4) · Chile (3) · Italy (3) · Puerto Rico (3) · Belgium (2) · Argentina (1) · Bulgaria (1) · China (1) · Egypt (1)
ObsEva SA (2) · Andrea Olariu, MD, PhD (1) · Charles T Cash, MD (1) · J.A. Reekers, MD, PhD (1) · Jorma Paavonen, prof (1) · Juha Teperi, prof (1) · Kay Dickersin, PhD (1) · Ritva S Hurskainen, MD, PhD (1) · Ron Sagiv, M.D. (1)
PMID 34878624, PMID 36357960, PMID 37477173, PMID 37863160, PMID 21043553, PMID 23188490, PMID 30865281, PMID 31971678, PMID 33596357, PMID 33650259, PMID 34553161, PMID 34582715, PMID 35415708, PMID 35675604, PMID 36116480, PMID 37183454, PMID 39381651, PMID 39466126, PMID 40326221, PMID 40543832, PMID 15547547, PMID 16880310, PMID 17671809, PMID 18055721, PMID 18567277, PMID 18752459, PMID 19111789, PMID 19682342, PMID 20733445, PMID 20859150, PMID 20942615, PMID 21475963, PMID 21777897, PMID 21867401, PMID 22748952, PMID 22959906, PMID 31777761, PMID 32702363, PMID 37023455, PMID 37666383, PMID 40320117
2016 (2), 2017 (1), 2018 (1)