9 recruiting, 3 completed, 1 not yet recruiting, 1 terminated. 10 Phase 1, 4 Phase 2, 1 Early Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Recruiting 5, Completed 3, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 4 | Recruiting 3, Terminated 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Not applicable | 1 | Recruiting 1 |
Follow Medulloblastoma Recurrent: new trials by email Literature Review of Medulloblastoma Recurrent trials Research Report on Medulloblastoma Recurrent
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| B7-H3.CD28Z.CART in CNS Neoplasms B7-H3.CD28Z.CART, Fludarabine, Cyclophosphamide - Central Nervous System Neoplasms, Brain Tumor | Phase 1 | Recruiting | Robbie Majzner | 70 | 2026-09-01 | 2026-09-03 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Study of CDK8 Inhibitor RVU120 in Combination With Everolimus in Children With Recurrent or Progressive Group 3 or 4 Medulloblastoma RVU120, Everolimus (Afinitor) tablets - Medulloblastoma Recurrent, Medulloblastoma | Phase 1 | Not yet recruiting | Bożenna Dembowska Bagińska | 48 | 2026-09-01 | 2026-10-08 |
| Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Liothyronine (L-T3), Bevacizumab, Irinotecan - Medulloblastoma, Medulloblastoma, Childhood | Phase 1 / Phase 2 | Recruiting | Sabine Mueller, MD, PhD | 69 | 2026-08-21 | 2026-09-28 |
| A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab - CNS Malignancies, Medulloblastoma Recurrent | Early Phase 1 | Recruiting | Children's National Research Institute | 18 | 2025-12-16 | 2026-04-29 |
| Relapsed and Progressive Sonic Hedgehog Medulloblastoma With U1 Mutation Registry Study Medulloblastoma Recurrent, Medulloblastoma, Childhood, Recurrent | Recruiting | Mohammad H. Abu Arja | 300 | 2025-09-30 | 2026-09-01 | |
| Study in Children and Adolescents of 177Lu-DOTATATE (Lutathera®) Combined With the PARP Inhibitor Olaparib for the Treatment of Recurrent or Relapsed Solid Tumours Expressing Somatostatin Receptor (SSTR) (LuPARPed). Olaparib; 177Lu-DOTATATE - Solid Tumor Cancer, Medulloblastoma | Phase 1 / Phase 2 | Recruiting | Fundación de investigación HM | 25 | 2024-09-20 | 2026-06-04 |
| Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma and Ependymoma Specialized Tumor Board Treatment Plan, Combinations - Medulloblastoma, Medulloblastoma, Childhood | Not applicable | Recruiting | University of California, San Francisco | 74 | 2022-02-22 | 2026-08-11 |
| HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors G207 - Neoplasms, Brain, Glioblastoma Multiforme | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 24 | 2019-09-12 | 2026-09-04 |
| Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors Prexasertib, Cyclophosphamide, Gemcitabine - Brain Tumor, Brain Tumor, Recurrent | Phase 1 | Completed | St. Jude Children's Research Hospital | 21 | 2019-08-08 | 2025-02-07 |
| Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery CX 4945 - Medulloblastoma, Childhood, Medulloblastoma Recurrent | Phase 1 / Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 21 | 2019-07-25 | 2026-10-19 |
| Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma CMV-DCs with GM-CSF, Td (tetanus toxoid) - Glioblastoma, Malignant Glioma | Phase 1 | Completed | Gary Archer Ph.D. | 11 | 2018-10-05 | 2021-01-28 |
| Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT Modified Measles Virus, Modified Measles Virus Lumbar Puncture - Medulloblastoma, Childhood, Recurrent, Atypical Teratoid/Rhabdoid Tumor | Phase 1 | Completed | Sabine Mueller, MD, PhD | 34 | 2017-02-22 | 2024-03-20 |
| Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS Tumors Bevacizumab, Thalidomide, Celecoxib - Medulloblastoma Recurrent, Ependymoma Recurrent | Phase 2 | Recruiting | Medical University of Vienna | 232 | 2014-04-01 | 2026-10-13 |
Medulloblastoma (12) · Recurrence (6) · Ependymoma (5) · Brain Neoplasms (4) · Central Nervous System Neoplasms (4) · Glioma (4) · Rhabdoid Tumor (4) · Glioblastoma (3) · Astrocytoma (2) · Microphthalmia, Isolated, with Coloboma 5 (2) · Neoplasms, Germ Cell and Embryonal (2) · Neuroectodermal Tumors, Primitive (2) · Pinealoma (2) · Adrenal Cortex Neoplasms (1) · Adrenal Gland Neoplasms (1)
Neoplasms (13) · Neoplasms by Histologic Type (13) · Neoplasms, Glandular and Epithelial (13) · Neoplasms, Nerve Tissue (13) · Neoplasms, Neuroepithelial (13) · Neuroectodermal Tumors (13) · Neoplasms, Germ Cell and Embryonal (12) · Neuroectodermal Tumors, Primitive (10) · Glioma (9) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Disease Attributes (6) · Neoplasms by Site (5) · Nervous System Diseases (5) · Nervous System Neoplasms (5)
Cyclophosphamide (3) · Bevacizumab (2) · Irinotecan (2) · Nivolumab (2) · Temozolomide (2) · Celecoxib (1) · Cytarabine (1) · Diphtheria Toxoid (1) · Etoposide (1) · Everolimus (1) · Filgrastim (1) · Gemcitabine (1) · Granulocyte Colony-Stimulating Factor (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Immunotherapy (1)
Children's National Research Institute (2) · Sabine Mueller, MD, PhD (2) · Bożenna Dembowska Bagińska (1) · Fundación de investigación HM (1) · Gary Archer Ph.D. (1) · M.D. Anderson Cancer Center (1) · Medical University of Vienna (1) · Mohammad H. Abu Arja (1) · Pediatric Brain Tumor Consortium (1) · Robbie Majzner (1) · St. Jude Children's Research Hospital (1) · University of California, San Francisco (1)
United States (12) · Spain (2) · Austria (1) · Czechia (1) · Denmark (1) · France (1) · Norway (1) · Poland (1) · Sweden (1)
Sabine Mueller, MD, PhD, MAS (2) · Amedeo A Azizi, MD (1) · Andreas Peyrl, MD (1) · Daniel Landi, MD (1) · Giles W. Robinson, MD (1) · Gregory Friedman, MD (1) · Lindsay Kilburn, MD (1) · Margaret Shatara, MD (1) · Marta Osuna Marco, PhD (1) · Megan Paul, MD (1) · Michael D Taylor, MD, PhD (1) · Mohammad H Abu-Arja, MD, MSc (1)
UM1CA081457 (1)